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| DOI | 10.1126/science.aav3900 |
| A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1 | |
| Le Nours, Jerome1,2,3; Gherardin, Nicholas A.4,5; Ramarathinam, Sri H.1,2; Awad, Wael1,2; Wiede, Florian1,2,6; Gully, Benjamin S.1,2,3; Khandokar, Yogesh1,2; Praveena, T.1,2; Wubben, Jacinta M.1,2; Sandow, Jarrod J.7,8; Webb, Andrew I.7,8; von Borstel, Anouk1,2,3; Rice, Michael T.1,2,3; Redmond, Samuel J.4; Seneviratna, Rebecca4; Sandoval-Romero, Maria L.1,2; Li, Shihan4,5; Souter, Michael N. T.4; Eckle, Sidonia B. G.4; Corbett, Alexandra J.4; Reid, Hugh H.1,2,3; Liu, Ligong9,10; Fairlie, David P.9,10; Giles, Edward M.11,12; Westall, Glen P.13,14; Tothill, Richard W.15,16,17; Davey, Martin S.1,2,3; Berry, Richard1,2,3; Tiganis, Tony1,2,6; McCluskey, James4; Pellicci, Daniel G.4,5; Purcell, Anthony W.1,2; Uldrich, Adam P.4,5; Godfrey, Dale I.4,5; Rossjohn, Jamie1,2,3,18 | |
| 2019-12-20 | |
| 发表期刊 | SCIENCE
 |
| ISSN | 0036-8075 |
| EISSN | 1095-9203 |
| 出版年 | 2019 |
| 卷号 | 366期号:6472页码:1522-+ |
| 文章类型 | Article |
| 语种 | 英语 |
| 国家 | Australia; Wales |
| 英文摘要 | T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human gamma delta T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a gamma delta TCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the gamma delta TCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 alpha 3 domain. A similar pattern of reactivity was observed for diverse MRl-restricted gamma delta TCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human gamma delta T cells and redefine the parameters for TCR recognition. |
| 领域 | 地球科学 ; 气候变化 ; 资源环境 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000503861000057 |
| WOS关键词 | CRYSTAL-STRUCTURE ; STRUCTURAL BASIS ; HETEROGENEITY ; COMPLEX ; HOST |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226511 |
| 专题 | 环境与发展全球科技态势 |
| 作者单位 | 1.Monash Univ, Biomed Discovery Inst, Infect & Immun Program, Clayton, Vic 3800, Australia; 2.Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia; 3.Monash Univ, Australian Res Council Ctr Excellence Adv Mol Ima, Clayton, Vic 3800, Australia; 4.Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3000, Australia; 5.Univ Melbourne, Australian Res Council Ctr Excellence Adv Mol Ima, Melbourne, Vic 3010, Australia; 6.Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia; 7.Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia; 8.Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia; 9.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia; 10.Univ Queensland, Australian Res Council Ctr Excellence Adv Mol Ima, Brisbane, Qld 4072, Australia; 11.Monash Univ, Dept Paediat, Clayton, Vic 3168, Australia; 12.Hudson Inst Med, Ctr Innate Immun & Infect Dis, Clayton, Vic 3168, Australia; 13.Alfred Hosp, Lung Transplant Serv, Melbourne, Vic 3004, Australia; 14.Monash Univ, Dept Med, Clayton, Vic 3800, Australia; 15.Univ Melbourne, Dept Clin Pathol, Parkville, Vic 3052, Australia; 16.Univ Melbourne, Ctr Canc Res, Parkville, Vic 3052, Australia; 17.Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3000, Australia; 18.Cardiff Univ, Inst Infect & Immun, Sch Med, Heath Pk, Cardiff CF14 4XN, S Glam, Wales |
| 推荐引用方式 GB/T 7714 | Le Nours, Jerome,Gherardin, Nicholas A.,Ramarathinam, Sri H.,et al. A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1[J]. SCIENCE,2019,366(6472):1522-+. |
| APA | Le Nours, Jerome.,Gherardin, Nicholas A..,Ramarathinam, Sri H..,Awad, Wael.,Wiede, Florian.,...&Rossjohn, Jamie.(2019).A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1.SCIENCE,366(6472),1522-+. |
| MLA | Le Nours, Jerome,et al."A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1".SCIENCE 366.6472(2019):1522-+. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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