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Protein-structure prediction gets real 期刊论文
NATURE, 2020, 577 (7792) : 627-628
作者:  Pillai, Arvind S.;  Chandler, Shane A.;  Liu, Yang;  Signor, Anthony, V;  Cortez-Romero, Carlos R.;  Benesch, Justin L. P.;  Laganowsky, Arthur;  Storz, Jay F.;  Hochberg, Georg K. A.;  Thornton, Joseph W.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Two threads of research in the quest for methods that predict the 3D structures of proteins from their amino-acid sequences have become fully intertwined. The result is a leap forward in the accuracy of predictions.


  
Deep learning takes on tumours 期刊论文
NATURE, 2020, 580 (7804) : 551-553
作者:  Dance, Amber
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/03

Artificial-intelligence methods are moving into cancer research.


Artificial-intelligence methods are moving into cancer research.


  
Redox-switchable carboranes for uranium capture and release 期刊论文
NATURE, 2020, 577 (7792) : 652-+
作者:  Marques, Joao C.;  Li, Meng;  Schaak, Diane;  Robson, Drew N.;  Li, Jennifer M.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

The uranyl ion (UO22+  U(vi) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremely strong chelating/binding affinities to UO22+ using chelating polymers(1,2), porous inorganic(3-5) or carbon-based(6,7) materials, as well as homogeneous(8) compounds. By contrast, the controlled release of uranyl after capture is less established and can be difficult, expensive or destructive to the initial material(2,9). Here we show how harnessing the redox-switchable chelating and donating properties of an ortho-substituted closo-carborane (1,2-(Ph2PO)(2)-1,2-C2B10H10) cluster molecule can lead to the controlled chemical or electrochemical capture and release of UO22+ in monophasic (organic) or biphasic (organic/aqueous) model solvent systems. This is achieved by taking advantage of the increase in the ligand bite angle when the closo-carborane is reduced to the nido-carborane, resulting in C-C bond rupture and cage opening. The use of electrochemical methods for uranyl capture and release may complement existing sorbent and processing systems.


Redox-switchable chelation is demonstrated for a carborane cluster molecule, leading to controlled chemical or electrochemical capture and release of uranyl in monophasic or biphasic model solvent systems.


  
Response to Comment on "Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene" 期刊论文
SCIENCE, 2019, 365 (6459)
作者:  Botsyun, Svetlana;  Sepulchre, Pierre;  Donnadieu, Yannick;  Risi, Camille;  Licht, Alexis;  Rugenstein, Jeremy K. Caves
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Response to Comment on "Observation of alkaline earth complexes M(CO)(8)(M = Ca, Sr, or Ba) that mimic transition metals" 期刊论文
SCIENCE, 2019, 365 (6453)
作者:  Zhao, Lili;  Pan, Sudip;  Zhou, Mingfei;  Frenking, Gernot
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Response to Comment on "Designing river flows to improve food security futures in the Lower Mekong Basin" 期刊论文
SCIENCE, 2019, 364 (6444)
作者:  Sabo, John L.;  Holtgrieve, Gordon W.;  Ruhi, Albert;  Arias, Mauricio E.;  Ngor, Peng Bun;  Elliott, Vittoria;  Rasanen, Timo;  Nam, So
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Lead isotopes in silver reveal earliest Phoenician quest for metals in the west Mediterranean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (13) : 6007-6012
作者:  Eshel, Tzilla;  Erel, Yigal;  Yahalom-Mack, Naama;  Tirosh, Ofir;  Gilboa, Ayelet
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
silver  lead isotope analysis  Phoenicians  Sardinia  Iberia  
Response to Comment on "The earliest modern humans outside Africa" 期刊论文
SCIENCE, 2018, 362 (6413)
作者:  Hershkovitz, Israel;  Duval, Mathieu;  Grun, Rainer;  Mercier, Norbert;  Valladas, Helene;  Ayalon, Avner;  Bar-Matthews, Miryam;  Weber, Gerhard W.;  Quam, Rolf;  Zaidner, Yossi;  Weinstein-Evron, Mina
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
JOURNALS UNDER THE MICROSCOPE "Journalologists" use scientific methods to study publishing. Is their work improving science? 期刊论文
SCIENCE, 2018, 361 (6408) : 1180-1183
作者:  Couzin-Frankel, Jennifer
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water" 期刊论文
SCIENCE, 2018, 361 (6405)
作者:  Best, Robert B.;  Zheng, Wenwei;  Borgia, Alessandro;  Buholzer, Karin;  Borgia, Madeleine B.;  Hofmann, Hagen;  Soranno, Andrea;  Nettels, Daniel;  Gast, Klaus;  Grishaev, Alexander;  Schuler, Benjamin
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27