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Development of 3-D Rift Heterogeneity Through Fault Network Evolution 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Naliboff, J. B.;  Glerum, A.;  Brune, S.;  Peron-Pinvidic, G.;  Wrona, T.
收藏  |  浏览/下载：1/0  |  提交时间：2020/05/25
Subduction megathrust heterogeneity characterized from 3D seismic data 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Kirkpatrick, James D.;  Edwards, Joel H.;  Verdecchia, Alessandro;  Kluesner, Jared W.;  Harrington, Rebecca M.;  Silver, Eli A.
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
Genomic basis for RNA alterations in cancer 期刊论文
NATURE, 2020, 578 (7793) : 129-+
作者:  Petitprez, Florent;  39;han
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Transcript alterations often result from somatic changes in cancer genomes(1). Various forms of RNA alterations have been described in cancer, including overexpression(2), altered splicing(3) and gene fusions(4)  however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(5). Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed '  bridged'  fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer.


  
Integration of WorldView-2 and airborne laser scanning data to classify defoliation levels in Quercus ilex L. Dehesas affected by root rot mortality: Management implications 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 451
作者:  Navarro-Cerrillo, Rafael M.;  Varo-Martinez, Ma Angeles;  Acosta, Cristina;  Palacios Rodriguez, Guillermo;  Sanchez-Cuesta, Rafael;  Gomez, Francisco J. Ruiz
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Dehesas forest type  Holm oak decline  Defoliation  Predictor remote sensing datasets  Segmentation  Random forest  
Extreme spatial heterogeneity in carbonate accretion potential on a Caribbean fringing reef linked to local human disturbance gradients 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  de Bakker, Didier M.;  van Duyl, Fleur C.;  Perry, Chris T.;  Meesters, Erik H.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Acropora cervicornis  bioerosion  Bonaire  calcification  carbonate budget  Caribbean  climate change  sea-level rise  
Tree species dynamics in Swiss forests as affected by site, stand and management: A retrospective analysis 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 448: 278-293
作者:  Nikolova, Petia Simeonova;  Rohner, Brigitte;  Zell, Jurgen;  Brang, Peter
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
Tree species richness  Swiss forest inventories  Management impact  Climate impact  Tree composition  
Evaluation of the FVS-CR diameter growth model in structurally-heterogeneous ponderosa pine (Pinus ponderosa Douglas ex C. Lawson) stands in the Southern Rockies, and potential modifications 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 448: 1-10
作者:  Dickinson, Yvette L.;  Battaglia, Michael A.;  Asherin, Lance A.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
GENGYM (GENeralized Growth and Yield Model)  Local competition  Crown ratio  
Time-resolved crystallography reveals allosteric communication aligned with molecular breathing 期刊论文
SCIENCE, 2019, 365 (6458) : 1167-+
作者:  Mehrabi, Pedram;  Schulz, Eike C.;  Dsouza, Raison;  Mueller-Werkmeister, Henrike M.;  Tellkamp, Friedjof;  Miller, R. J. Dwayne;  Pai, Emil F.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Molecular basis and biological function of variability in spatial genome organization 期刊论文
SCIENCE, 2019, 365 (6457) : 998-+
作者:  Finn, Elizabeth H.;  Misteli, Tom
收藏  |  浏览/下载：0/0  |  提交时间：2019/11/27
Linking forest growth with stand structure: Tree size inequality, tree growth or resource partitioning and the asymmetry of competition 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 447: 139-157
作者:  Forrester, David, I
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Asymmetric competition  Climate change  Continuous cover forestry  Growth dominance  Mixed species  Multi-aged  Size heterogeneity  Uneven-aged