Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4492 |
Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China | |
Song, Lulu1,2,3,4; Liu, Bingqing1,2,3,4; Wu, Mingyang1,2,3,4; Zhang, Lina1,2,3,4; Wang, Lulin1,2,3,4; Zhang, Bin5; Xiong, Chao5; Li, Yuanyuan2,3,4; Cao, Zhongyiang5; Wang, Youjie1,2,3,4; Xu, Shunqing2,3,4 | |
2019-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | BACKGROUND: Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. The setting of TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood. OBJECTIVES: The purpose of our study was to explore the relationships between prenatal exposure to phthalates and umbilical cord blood TL. METHODS: A total of 762 mother-newborn pairs were recruited from a birth cohort study performed between November 2013 and March 2015 in Wuhan, China. Relative cord blood TL was measured using quantitative real-time polymerase chain reaction. Six phthalate metabolites were measured in urine samples acquired from pregnant women during the three trimesters. Multiple informant models were applied to estimate the associations between prenatal exposure to phthalates and cord blood TL. and to evaluate potential windows of vulnerability. RESULTS: Exposure to mono-ethyl phthalate (MEP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-butyl phthalate (MBP), and di(2-ethylhexyl) phthalate (Sigma DEHP) during the first trimester were inversely related to cord blood TL. In addition, we observed a female-specific association between maternal exposure to MEP during the first trimester and cord blood TL (p(sex-int) =0.03). The associations between maternal exposure to MECPP, MEHHP, MEOHP, and Sigma DEHP during the first trimester and cord blood TL were consistent between males and females (all p(sex-int) > 0.10). CONCLUSION: This prospective study demonstrated that prenatal exposure to some phthalate metabolites were associated with shorter cord blood TL. Our results, if confirmed in other populations, may provide more evidence of adverse health outcomes of phthalate exposure and support the hypothesis that the intrauterine environment may be one of the major determinants for newborn TL. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483734400004 |
WOS关键词 | BISPHENOL-A EXPOSURE ; AIR-POLLUTION EXPOSURE ; GROWTH-FACTOR-I ; PREGNANT-WOMEN ; OXIDATIVE STRESS ; THYROID-FUNCTION ; LEAD-EXPOSURE ; FETAL-GROWTH ; ASSOCIATIONS ; METABOLITES |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/185565 |
专题 | 资源环境科学 |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Minist Educ, Wuhan, Hubei, Peoples R China; 3.Huazhong Univ Sci & Technol, Minist Environm Protect, Wuhan, Hubei, Peoples R China; 4.Huazhong Univ Sci & Technol, State Key Lab Environm Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China; 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Maternal & Child Healthcare Hosp, Wuhan Childrens Hosp, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Song, Lulu,Liu, Bingqing,Wu, Mingyang,et al. Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8). |
APA | Song, Lulu.,Liu, Bingqing.,Wu, Mingyang.,Zhang, Lina.,Wang, Lulin.,...&Xu, Shunqing.(2019).Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8). |
MLA | Song, Lulu,et al."Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019). |
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