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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate 期刊论文
Science, 2020
作者:  Sandhya Bangaru;  Gabriel Ozorowski;  Hannah L. Turner;  Aleksandar Antanasijevic;  Deli Huang;  Xiaoning Wang;  Jonathan L. Torres;  Jolene K. Diedrich;  Jing-Hui Tian;  Alyse D. Portnoff;  Nita Patel;  Michael J. Massare;  John R. Yates;  David Nemazee;  James C. Paulson;  Greg Glenn;  Gale Smith;  Andrew B. Ward
收藏  |  浏览/下载:14/0  |  提交时间:2020/11/30
Distinct responses of Asian summer monsoon to black carbon aerosols and greenhouse gases 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Xiaoning Xie, Gunnar Myhre, Xiaodong Liu, Xinzhou Li, Zhengguo Shi, Hongli Wang, Alf Kirkevåg, Jean-Francois Lamarque, Drew Shindell, Toshihiko Takemura, and Yangang Liu
收藏  |  浏览/下载:16/0  |  提交时间:2020/06/22
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Global NDVI Patterns in Response to Atmospheric Water Vapor Anomalies over the Indo-Pacific Warm Pool during April-June 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (4) : 1167-1180
作者:  Wang, Zhaosheng;  Huang, Mei;  Wang, Rong;  Wang, Shaoqiang;  Liu, Xiaodong;  Xie, Xiaoning;  Liu, Zhengjia;  Gong, He;  Hao, Man
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Atmosphere-land interaction  Biosphere-atmosphere interaction  Ecosystem effects  Geographic information systems (GIS)  Vegetation-atmosphere interactions  
Radiative feedbacks of dust in snow over eastern Asia in CAM4-BAM 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (17) : 12683-12698
作者:  Xie, Xiaoning;  Liu, Xiaodong;  Che, Huizheng;  Xie, Xiaoxun;  Li, Xinzhou;  Shi, Zhengguo;  Wang, Hongli;  Zhao, Tianliang;  Liu, Yangang
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Radiative feedbacks of dust in snow over eastern Asia in CAM4-BAM 期刊论文
Atmospheric Chemistry and Physics, 2018
作者:  Xiaoning Xie, Xiaodong Liu, Huizheng Che, Xiaoxun Xie, Xinzhou Li, Zhengguo Shi, Hongli Wang, Tianliang Zhao, and Yangang Liu
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/18
Modeling East Asian Dust and Its Radiative Feedbacks in CAM4-BAM 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (2) : 1079-1096
作者:  Xie, Xiaoning;  Liu, Xiaodong;  Che, Huizheng;  Xie, Xiaoxun;  Wang, Hongli;  Li, Jiandong;  Shi, Zhengguo;  Liu, Yangang
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
CAM4-BAM  dust-radiation interaction  dust cycle  
Higher yields and lower methane emissions with new rice cultivars 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Jiang, Yu;  van Groenigen, Kees Jan;  Huang, Shan;  Hungate, Bruce A.;  van Kessel, Chris;  Hu, Shuijin;  Zhang, Jun;  Wu, Lianhai;  Yan, Xiaojun;  Wang, Lili;  Chen, Jin;  Hang, Xiaoning;  Zhang, Yi;  Horwath, William R.;  Ye, Rongzhong;  Linquist, Bruce A.;  Song, Zhenwei;  Zheng, Chengyan;  Deng, Aixing;  Zhang, Weijian
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
meta-analysis  methanogenesis  methanotrophy  roots  soil carbon