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Measurement report: Distinct size dependence and diurnal variation in organic aerosol hygroscopicity, volatility, and cloud condensation nuclei activity at a rural site in the Pearl River Delta (PRD) region, China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Mingfu Cai, Shan Huang, Baoling Liang, Qibin Sun, Li Liu, Bin Yuan, Min Shao, Weiwei Hu, Wei Chen, Qicong Song, Wei Li, Yuwen Peng, Zelong Wang, Duohong Chen, Haobo Tan, Hanbin Xu, Fei Li, Xuejiao Deng, Tao Deng, Jiaren Sun, and Jun Zhao
收藏  |  浏览/下载:15/0  |  提交时间:2022/06/24
Strengthened Relationship between Tropical Indian Ocean Dipole and Subtropical Indian Ocean Dipole after the late 2000s 期刊论文
Geophysical Research Letters, 2021
作者:  Bicheng Huang;  Tao Su;  Shulin Qu;  Han Zhang;  Shujuan Hu;  Guolin Feng
收藏  |  浏览/下载:13/0  |  提交时间:2021/10/07
Distinct Interdecadal Change Contrasts between Summer and Autumn in Latitude-Longitude Covariability of Northwest Pacific Typhoon Genesis Locations 期刊论文
Geophysical Research Letters, 2021
作者:  Zeming Wu;  Chundi Hu;  Junbin Wang;  Weizhen Chen;  Tao Lian;  Song Yang;  Dake Chen
收藏  |  浏览/下载:8/0  |  提交时间:2021/08/10
The association between maternal exposure to fine particulate matter (PM2.5) and gestational diabetes mellitus (GDM): a prospective birth cohort study in China 期刊论文
Environmental Research Letters, 2021
作者:  Guimin Chen;  Xiaoli Sun;  Jiaqi Wang;  Moran Dong;  Yufeng Ye;  Xin Liu;  Jiufeng Sun;  Jianpeng Xiao;  Guanhao He;  Jianxiong Hu;  Lingchuan Guo;  Xing Li;  Zuhua Rong;  Weilin Zeng;  He Zhou;  Dengzhou Chen;  Jiali Li;  Wenjun Ma;  Maksym Bartashevskyy;  Xiaozhong Wen;  Tao Liu
收藏  |  浏览/下载:11/0  |  提交时间:2021/04/20
Air Pollutants and Greenhouse Gas Emissions Co-control Evaluation in the People’s Republic of China 科技报告
来源:Asian Development Bank. 出版年: 2020
作者:  Tao Hu;  Xianqiang Mao;  Xuedu Lu
收藏  |  浏览/下载:8/0  |  提交时间:2020/12/22
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/20
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Rapid formation of intense haze episodes via aerosol-boundary layer feedback in Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (1) : 45-53
作者:  Wang, Yonghong;  Yu, Miao;  Wang, Yuesi;  Tang, Guiqian;  Song, Tao;  Zhou, Putian;  Liu, Zirui;  Hu, Bo;  Ji, Dongsheng;  Wang, Lili;  Zhu, Xiaowan;  Yan, Chao;  Ehn, Mikael;  Gao, Wenkang;  Pan, Yuepeng;  Xin, Jinyuan;  Sun, Yang;  Kerminen, Veli-Matti;  Kulmala, Markku;  Petaja, Tuukka
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
A deep learning approach to conflating heterogeneous geospatial data for corn yield estimation: A case study of the US Corn Belt at the county level 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Jiang, Hao;  Hu, Hao;  Zhong, Renhai;  Xu, Jinfan;  Xu, Jialu;  Huang, Jingfeng;  Wang, Shaowen;  Ying, Yibin;  Lin, Tao
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
climate change impact  corn yield  deep learning  geospatial discovery  phenology