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Regime-dependent impacts of aerosol particles and updrafts on the cloud concentration nuclei and the enhanced warm rain suppression: evidence from synergistic satellite and LiDAR observations 期刊论文
Geophysical Research Letters, 2022
作者:  Tao Huang;  Yannian Zhu;  Daniel Rosenfeld;  Yuanjian Yang;  David H. Y. Lam;  W. H. Leung;  Harry F. Lee;  Jack C. H. Cheng;  Steve H. L. Yim
收藏  |  浏览/下载:12/0  |  提交时间:2022/02/16
Much stronger tundra methane emissions during autumn freeze than spring thaw 期刊论文
Global Change Biology, 2020
作者:  Tao Bao;  Xiyan Xu;  Gensuo Jia;  David P. Billesbach;  Ryan C. Sullivan
收藏  |  浏览/下载:9/0  |  提交时间:2020/11/20
Modelling climate change impacts on maize yields under low nitrogen input conditions in sub‐Saharan Africa 期刊论文
Global Change Biology, 2020
作者:  Gatien N. Falconnier;  Marc Corbeels;  Kenneth J. Boote;  Franç;  ois Affholder;  Myriam Adam;  Dilys S. MacCarthy;  Alex C. Ruane;  Claas Nendel;  Anthony M. Whitbread;  É;  ric Justes;  Lajpat R. Ahuja;  Folorunso M. Akinseye;  Isaac N. Alou;  Kokou A. Amouzou;  Saseendran S. Anapalli;  Christian Baron;  Bruno Basso;  Fré;  ;  ric Baudron;  Patrick Bertuzzi;  Andrew J. Challinor;  Yi Chen;  Delphine Deryng;  Maha L. Elsayed;  Babacar Faye;  Thomas Gaiser;  Marcelo Galdos;  Sebastian Gayler;  Edward Gerardeaux;  Michel Giner;  Brian Grant;  Gerrit Hoogenboom;  Esther S. Ibrahim;  Bahareh Kamali;  Kurt Christian Kersebaum;  Soo‐;  Hyung Kim;  Michael van der Laan;  Louise Leroux;  Jon I. Lizaso;  Bernardo Maestrini;  Elizabeth A. Meier;  Fasil Mequanint;  Alain Ndoli;  Cheryl H. Porter;  Eckart Priesack;  Dominique Ripoche;  Tesfaye S. Sida;  Upendra Singh;  Ward N. Smith;  Amit Srivastava;  Sumit Sinha;  Fulu Tao;  Peter J. Thorburn;  Dennis Timlin;  Bouba Traore;  Tracy Twine;  Heidi Webber
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/25
PIRs mediate innate myeloid cell memory to nonself MHC molecules 期刊论文
Science, 2020
作者:  Hehua Dai;  Peixiang Lan;  Daqiang Zhao;  Khodor Abou-Daya;  Wentao Liu;  Wenhao Chen;  Andrew J. Friday;  Amanda L. Williams;  Tao Sun;  Jianjiao Chen;  Wei Chen;  Steven Mortin-Toth;  Jayne S. Danska;  Chris Wiebe;  Peter Nickerson;  Tengfang Li;  Lisa R. Mathews;  Hêth R. Turnquist;  Matthew L. Nicotra;  Sebastien Gingras;  Eiji Takayama;  Hiromi Kubagawa;  Mark J. Shlomchik;  Martin H. Oberbarnscheidt;  Xian C. Li;  Fadi G. Lakkis
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/09
There’s plenty of room at the Top: What will drive computer performance after Moore’s law? 期刊论文
Science, 2020
作者:  Charles E. Leiserson;  Neil C. Thompson;  Joel S. Emer;  Bradley C. Kuszmaul;  Butler W. Lampson;  Daniel Sanchez;  Tao B. Schardl
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09
The acidity of atmospheric particles and clouds 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 4809-4888
作者:  Pye, Havala O. T.;  Nenes, Athanasios;  Alexander, Becky;  Ault, Andrew P.;  Barth, Mary C.;  Clegg, Simon L.;  Collett, Jeffrey L., Jr.;  Fahey, Kathleen M.;  Hennigan, Christopher J.;  Herrmann, Hartmut;  Kanakidou, Maria;  Kelly, James T.;  Ku, I-Ting;  McNeill, V. Faye;  Riemer, Nicole;  Schaefer, Thomas;  Shi, Guoliang;  Tilgner, Andreas;  Walker, John T.;  Wang, Tao;  Weber, Rodney;  Xing, Jia;  Zaveri, Rahul A.;  Zuend, Andreas
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Electron mixing and isotropization in the exhaust of asymmetric magnetic reconnection with a guide field 期刊论文
Geophysical Research Letters, 2020
作者:  B. B. Tang;  W. Y. Li;  A. Le;  D. B. Graham;  Y. F. Wu;  C. Wang;  Yu. V. Khotyaintsev;  J. Egedal;  X. Tao;  D. J. Gershman;  B. L. Giles;  P. A. Lindqvist;  R. E. Ergun;  C. T. Russell;  J. L. Burch
收藏  |  浏览/下载:13/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
A lower X-gate in TASK channels traps inhibitors within the vestibule 期刊论文
NATURE, 2020
作者:  Chen, Tao;  Nomura, Kinya;  Wang, Xiaolin;  Sohrabi, Reza;  Xu, Jin;  Yao, Lingya;  Paasch, Bradley C.;  Ma, Li;  Kremer, James;  Cheng, Yuti;  Zhang, Li;  Wang, Nian;  Wang, Ertao;  Xin, Xiu-Fang;  He, Sheng Yang
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/03

TWIK-related acid-sensitive potassium (TASK) channels-members of the two pore domain potassium (K-2P) channel family-are found in neurons(1), cardiomyocytes(2-4) and vascular smooth muscle cells(5), where they are involved in the regulation of heart rate(6), pulmonary artery tone(5,7), sleep/wake cycles(8) and responses to volatile anaesthetics(8-11). K-2P channels regulate the resting membrane potential, providing background K+ currents controlled by numerous physiological stimuli(12-15). Unlike other K-2P channels, TASK channels are able to bind inhibitors with high affinity, exceptional selectivity and very slow compound washout rates. As such, these channels are attractive drug targets, and TASK-1 inhibitors are currently in clinical trials for obstructive sleep apnoea and atrial fibrillation(16). In general, potassium channels have an intramembrane vestibule with a selectivity filter situated above and a gate with four parallel helices located below  however, the K-2P channels studied so far all lack a lower gate. Here we present the X-ray crystal structure of TASK-1, and show that it contains a lower gate-which we designate as an '  X-gate'  -created by interaction of the two crossed C-terminal M4 transmembrane helices at the vestibule entrance. This structure is formed by six residues ((VLRFMT248)-V-243) that are essential for responses to volatile anaesthetics(10), neurotransmitters(13) and G-protein-coupled receptors(13). Mutations within the X-gate and the surrounding regions markedly affect both the channel-open probability and the activation of the channel by anaesthetics. Structures of TASK-1 bound to two high-affinity inhibitors show that both compounds bind below the selectivity filter and are trapped in the vestibule by the X-gate, which explains their exceptionally low washout rates. The presence of the X-gate in TASK channels explains many aspects of their physiological and pharmacological behaviour, which will be beneficial for the future development and optimization of TASK modulators for the treatment of heart, lung and sleep disorders.


The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.