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Meeting sustainable development goals via robotics and autonomous systems 期刊论文
Nature Communications, 2022
作者:  Guenat, Solè;  ne;  Purnell, Phil;  Davies, Zoe G.;  Nawrath, Maximilian;  Stringer, Lindsay C.;  Babu, Giridhara Rathnaiah;  Balasubramanian, Muniyandi;  Ballantyne, Erica E. F.;  Bylappa, Bhuvana Kolar;  Chen, Bei;  De Jager, Peta;  Del Prete, Andrea;  Di Nuovo, Alessandro;  Ehi-Eromosele, Cyril O.;  Eskandari Torbaghan, Mehran;  Evans, Karl L.;  Fraundorfer, Markus;  Haouas, Wissem;  Izunobi, Josephat U.;  Jauregui-Correa, Juan Carlos;  Kaddouh, Bilal Y.;  Lewycka, Sonia;  MacIntosh, Ana C.;  Mady, Christine;  Maple, Carsten;  Mhiret, Worku N.;  Mohammed-Amin, Rozhen Kamal;  Olawole, Olukunle Charles;  Oluseyi, Temilola;  Orfila, Caroline;  Ossola, Alessandro;  Pfeifer, Marion;  Pridmore, Tony;  Rijal, Moti L.;  Rega-Brodsky, Christine C.;  Robertson, Ian D.;  Rogers, Christopher D. F.;  Rougé;  , Charles;  Rumaney, Maryam B.;  Seeletso, Mmabaledi K.;  Shaqura, Mohammed Z.;  Suresh, L. M.;  Sweeting, Martin N.;  Taylor Buck, Nick;  Ukwuru, M. U.;  Verbeek, Thomas;  Voss, Hinrich;  Wadud, Zia;  Wang, Xinjun;  Winn, Neil;  Dallimer, Martin
收藏  |  浏览/下载:7/0  |  提交时间:2022/06/24
Surviving winter on the Qinghai-Tibetan Plateau: Pikas suppress energy demands and exploit yak feces to survive winter 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  John R. Speakman;  Qingsheng Chi;  Łukasz Ołdakowski;  Haibo Fu;  Quinn E. Fletcher;  Catherine Hambly;  Jacques Togo;  Xinyu Liu;  Stuart B. Piertney;  Xinghao Wang;  Liangzhi Zhang;  Paula Redman;  Lu Wang;  Gangbin Tang;  Yongguo Li;  Jianguo Cui;  Peter J. Thomson;  Zengli Wang;  Paula Glover;  Olivia C. Robertson;  Yanming Zhang;  Dehua Wang
收藏  |  浏览/下载:10/0  |  提交时间:2021/07/27
Approaching the motional ground state of a 10-kg object 期刊论文
Science, 2021
作者:  Chris Whittle;  Evan D. Hall;  Sheila Dwyer;  Nergis Mavalvala;  Vivishek Sudhir;  R. Abbott;  A. Ananyeva;  C. Austin;  L. Barsotti;  J. Betzwieser;  C. D. Blair;  A. F. Brooks;  D. D. Brown;  A. Buikema;  C. Cahillane;  J. C. Driggers;  A. Effler;  A. Fernandez-Galiana;  P. Fritschel;  V. V. Frolov;  T. Hardwick;  M. Kasprzack;  K. Kawabe;  N. Kijbunchoo;  J. S. Kissel;  G. L. Mansell;  F. Matichard;  L. McCuller;  T. McRae;  A. Mullavey;  A. Pele;  R. M. S. Schofield;  D. Sigg;  M. Tse;  G. Vajente;  D. C. Vander-Hyde;  Hang Yu;  Haocun Yu;  C. Adams;  R. X. Adhikari;  S. Appert;  K. Arai;  J. S. Areeda;  Y. Asali;  S. M. Aston;  A. M. Baer;  M. Ball;  S. W. Ballmer;  S. Banagiri;  D. Barker;  J. Bartlett;  B. K. Berger;  D. Bhattacharjee;  G. Billingsley;  S. Biscans;  R. M. Blair;  N. Bode;  P. Booker;  R. Bork;  A. Bramley;  K. C. Cannon;  X. Chen;  A. A. Ciobanu;  F. Clara;  C. M. Compton;  S. J. Cooper;  K. R. Corley;  S. T. Countryman;  P. B. Covas;  D. C. Coyne;  L. E. H. Datrier;  D. Davis;  C. Di Fronzo;  K. L. Dooley;  P. Dupej;  T. Etzel;  M. Evans;  T. M. Evans;  J. Feicht;  P. Fulda;  M. Fyffe;  J. A. Giaime;  K. D. Giardina;  P. Godwin;  E. Goetz;  S. Gras;  C. Gray;  R. Gray;  A. C. Green;  E. K. Gustafson;  R. Gustafson;  J. Hanks;  J. Hanson;  R. K. Hasskew;  M. C. Heintze;  A. F. Helmling-Cornell;  N. A. Holland;  J. D. Jones;  S. Kandhasamy;  S. Karki;  P. J. King;  Rahul Kumar;  M. Landry;  B. B. Lane;  B. Lantz;  M. Laxen;  Y. K. Lecoeuche;  J. Leviton;  J. Liu;  M. Lormand;  A. P. Lundgren;  R. Macas;  M. MacInnis;  D. M. Macleod;  S. Márka;  Z. Márka;  D. V. Martynov;  K. Mason;  T. J. Massinger;  R. McCarthy;  D. E. McClelland;  S. McCormick;  J. McIver;  G. Mendell;  K. Merfeld;  E. L. Merilh;  F. Meylahn;  T. Mistry;  R. Mittleman;  G. Moreno;  C. M. Mow-Lowry;  S. Mozzon;  T. J. N. Nelson;  P. Nguyen;  L. K. Nuttall;  J. Oberling;  Richard J. Oram;  C. Osthelder;  D. J. Ottaway;  H. Overmier;  J. R. Palamos;  W. Parker;  E. Payne;  R. Penhorwood;  C. J. Perez;  M. Pirello;  H. Radkins;  K. E. Ramirez;  J. W. Richardson;  K. Riles;  N. A. Robertson;  J. G. Rollins;  C. L. Romel;  J. H. Romie;  M. P. Ross;  K. Ryan;  T. Sadecki;  E. J. Sanchez;  L. E. Sanchez;  T. R. Saravanan;  R. L. Savage;  D. Schaetz;  R. Schnabel;  E. Schwartz;  D. Sellers;  T. Shaffer;  B. J. J. Slagmolen;  J. R. Smith;  S. Soni;  B. Sorazu;  A. P. Spencer;  K. A. Strain;  L. Sun;  M. J. Szczepańczyk;  M. Thomas;  P. Thomas;  K. A. Thorne;  K. Toland;  C. I. Torrie;  G. Traylor;  A. L. Urban;  G. Valdes;  P. J. Veitch;  K. Venkateswara;  G. Venugopalan;  A. D. Viets;  T. Vo;  C. Vorvick;  M. Wade;  R. L. Ward;  J. Warner;  B. Weaver;  R. Weiss;  B. Willke;  C. C. Wipf;  L. Xiao;  H. Yamamoto;  L. Zhang;  M. E. Zucker;  J. Zweizig
收藏  |  浏览/下载:16/0  |  提交时间:2021/06/24
Sense codon reassignment enables viral resistance and encoded polymer synthesis 期刊论文
Science, 2021
作者:  Wesley E. Robertson;  Louise F. H. Funke;  Daniel de la Torre;  Julius Fredens;  Thomas S. Elliott;  Martin Spinck;  Yonka Christova;  Daniele Cervettini;  Franz L. Böge;  Kim C. Liu;  Salvador Buse;  Sarah Maslen;  George P. C. Salmond;  Jason W. Chin
收藏  |  浏览/下载:26/0  |  提交时间:2021/06/15
Linking 19th century European settlement to the disruption of a seabird’s natural population dynamics 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Matthew P. Duda;  Sylvie Allen-Mahé;  Christophe Barbraud;  Jules M. Blais;  Amaël Boudreau;  Rachel Bryant;  Karine Delord;  Christopher Grooms;  Linda E. Kimpe;  Bruno Letournel;  Joeline E. Lim;  Hervé Lormée;  Neal Michelutti;  Gregory J. Robertson;  Frank Urtizbéréa;  Sabina I. Wilhelm;  John P. Smol
收藏  |  浏览/下载:10/0  |  提交时间:2020/12/22
Using structured eradication feasibility assessment to prioritize the management of new and emerging invasive alien species in Europe 期刊论文
Global Change Biology, 2020
作者:  Olaf Booy;  Pete A. Robertson;  Niall Moore;  Jess Ward;  Helen E. Roy;  Tim Adriaens;  Richard Shaw;  Johan Van Valkenburg;  Gabrielle Wyn;  Sandro Bertolino;  Olivier Blight;  Etienne Branquart;  Giuseppe Brundu;  Joe Caffrey;  Dario Capizzi;  Jim Casaer;  Olivier De Clerck;  Neil E. Coughlan;  Eithne Davis;  Jaimie T. A. Dick;  Franz Essl;  Guillaume Fried;  Piero Genovesi;  Pablo Gonzá;  lez‐;  Moreno;  Frank Huysentruyt;  Stuart R. Jenkins;  Francis Kerckhof;  Lucy E. Frances;  Wolfgang Nentwig;  Jonathan Newman;  Wolfgang Rabitsch;  Sugoto Roy;  Uwe Starfinger;  Paul D. Stebbing;  Jan Stuyck;  Mike Sutton‐;  Croft;  Elena Tricarico;  Sonia Vanderhoeven;  Hugo Verreycken;  Aileen C. Mill
收藏  |  浏览/下载:11/0  |  提交时间:2020/09/08
The Madden-Julian Oscillation Affects Maize Yields Throughout the Tropics and Subtropics 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Anderson, W. B.;  Han, E.;  Baethgen, W.;  Goddard, L.;  Munoz, A. G.;  Robertson, A. W.
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/13
Madden-Julian Oscillation  crop failure  S2S  food security  drought  subseasonal  
Increased control of vegetation on global terrestrial energy fluxes 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (4) : 356-+
作者:  Forzieri, Giovanni;  Miralles, Diego G.;  Ciais, Philippe;  Alkama, Ramdane;  Ryu, Youngryel;  Duveiller, Gregory;  Zhang, Ke;  Robertson, Eddy;  Kautz, Markus;  Martens, Brecht;  Jiang, Chongya;  Arneth, Almut;  Georgievski, Goran;  Li, Wei;  Ceccherini, Guido;  Anthoni, Peter;  Lawrence, Peter;  Wiltshire, Andy;  Pongratz, Julia;  Piao, Shilong;  Sitch, Stephen;  Goll, Daniel S.;  Arora, Vivek K.;  Lienert, Sebastian;  Lombardozzi, Danica;  Kato, Etsushi;  Nabel, Julia E. M. S.;  Tian, Hanqin;  Friedlingstein, Pierre;  Cescatti, Alessandro
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms 期刊论文
NATURE, 2020, 579 (7800) : 609-+
作者:  Huang, Weijiao;  Masureel, Matthieu;  Qu, Qianhui;  Janetzko, John;  Inoue, Asuka;  Kato, Hideaki E.;  Robertson, Michael J.;  Nguyen, Khanh C.;  Glenn, Jeffrey S.;  Skiniotis, Georgios;  Kobilka, Brian K.
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus, synchronizing the physiology and behaviour of animals to the light-dark cycle(1-4). The two receptors are established drug targets for aligning circadian phase to this cycle in disorders of sleep(5,6) and depression(1-4,7-9). Despite their importance, few in vivo active MT1-selective ligands have been reported(2,8,10-12), hampering both the understanding of circadian biology and the development of targeted therapeutics. Here we docked more than 150 million virtual molecules to an MT1 crystal structure, prioritizing structural fit and chemical novelty. Of these compounds, 38 high-ranking molecules were synthesized and tested, revealing ligands with potencies ranging from 470 picomolar to 6 micromolar. Structure-based optimization led to two selective MT1 inverse agonists-which were topologically unrelated to previously explored chemotypes-that acted as inverse agonists in a mouse model of circadian re-entrainment. Notably, we found that these MT1-selective inverse agonists advanced the phase of the mouse circadian clock by 1.3-1.5 h when given at subjective dusk, an agonist-like effect that was eliminated in MT1- but not in MT2-knockout mice. This study illustrates the opportunities for modulating melatonin receptor biology through MT1-selective ligands and for the discovery of previously undescribed, in vivo active chemotypes from structure-based screens of diverse, ultralarge libraries. A computational screen of an ultra-large virtual library against the structure of the melatonin receptor found nanomolar ligands, and ultimately two selective MT1 inverse agonists that induced phase advancement of the mouse circadian clock when given at subjective dusk.


  
Caveolae in CNS arterioles mediate neurovascular coupling 期刊论文
NATURE, 2020
作者:  Huang, Weijiao;  Masureel, Matthieu;  Qu, Qianhui;  Janetzko, John;  Inoue, Asuka;  Kato, Hideaki E.;  Robertson, Michael J.;  Nguyen, Khanh C.;  Glenn, Jeffrey S.;  Skiniotis, Georgios;  Kobilka, Brian K.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

Caveolae in arteriolar endothelial cells-but not those in neighbouring smooth muscle cells-have a key role in neurovascular coupling, an essential function for meeting acute brain energy demand.


Proper brain function depends on neurovascular coupling: neural activity rapidly increases local blood flow to meet moment-to-moment changes in regional brain energy demand(1). Neurovascular coupling is the basis for functional brain imaging(2), and impaired neurovascular coupling is implicated in neurodegeneration(1). The underlying molecular and cellular mechanisms of neurovascular coupling remain poorly understood. The conventional view is that neurons or astrocytes release vasodilatory factors that act directly on smooth muscle cells (SMCs) to induce arterial dilation and increase local blood flow(1). Here, using two-photon microscopy to image neural activity and vascular dynamics simultaneously in the barrel cortex of awake mice under whisker stimulation, we found that arteriolar endothelial cells (aECs) have an active role in mediating neurovascular coupling. We found that aECs, unlike other vascular segments of endothelial cells in the central nervous system, have abundant caveolae. Acute genetic perturbations that eliminated caveolae in aECs, but not in neighbouring SMCs, impaired neurovascular coupling. Notably, caveolae function in aECs is independent of the endothelial NO synthase (eNOS)-mediated NO pathway. Ablation of both caveolae and eNOS completely abolished neurovascular coupling, whereas the single mutants exhibited partial impairment, revealing that the caveolae-mediated pathway in aECs is a major contributor to neurovascular coupling. Our findings indicate that vasodilation is largely mediated by endothelial cells that actively relay signals from the central nervous system to SMCs via a caveolae-dependent pathway.