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Time-Fractional Flow Equations (t-FFEs) to Upscale Transient Groundwater Flow Characterized by Temporally Non-Darcian Flow Due to Medium Heterogeneity 期刊论文
Water Resources Research, 2021
作者:  Yuan Xia;  Yong Zhang;  Christopher T. Green;  Graham E. Fogg
收藏  |  浏览/下载：20/0  |  提交时间：2021/10/07
Wealth and urbanization shape medium and large terrestrial mammal communities 期刊论文
Global Change Biology, 2021
作者:  Seth B. Magle;  Mason Fidino;  Heather A. Sander;  Adam T. Rohnke;  Kelli L. Larson;  Travis Gallo;  Cria A. M. Kay;  Elizabeth W. Lehrer;  Maureen H. Murray;  Solny A. Adalsteinsson;  Adam A. Ahlers;  Whitney J. B. Anthonysamy;  Ashley R. Gramza;  Austin M. Green;  Mark J. Jordan;  Jesse S. Lewis;  Robert A. Long;  Brandon MacDougall;  Mary E. Pendergast;  Katie Remine;  Kelly Conrad Simon;  Colleen C. St. Clair;  Catherine J. Shier;  Theodore Stankowich;  Cassondra J. Stevenson;  Amanda J. Zellmer;  Christopher J. Schell
收藏  |  浏览/下载：16/0  |  提交时间：2021/08/25
Approaching the motional ground state of a 10-kg object 期刊论文
Science, 2021
作者:  Chris Whittle;  Evan D. Hall;  Sheila Dwyer;  Nergis Mavalvala;  Vivishek Sudhir;  R. Abbott;  A. Ananyeva;  C. Austin;  L. Barsotti;  J. Betzwieser;  C. D. Blair;  A. F. Brooks;  D. D. Brown;  A. Buikema;  C. Cahillane;  J. C. Driggers;  A. Effler;  A. Fernandez-Galiana;  P. Fritschel;  V. V. Frolov;  T. Hardwick;  M. Kasprzack;  K. Kawabe;  N. Kijbunchoo;  J. S. Kissel;  G. L. Mansell;  F. Matichard;  L. McCuller;  T. McRae;  A. Mullavey;  A. Pele;  R. M. S. Schofield;  D. Sigg;  M. Tse;  G. Vajente;  D. C. Vander-Hyde;  Hang Yu;  Haocun Yu;  C. Adams;  R. X. Adhikari;  S. Appert;  K. Arai;  J. S. Areeda;  Y. Asali;  S. M. Aston;  A. M. Baer;  M. Ball;  S. W. Ballmer;  S. Banagiri;  D. Barker;  J. Bartlett;  B. K. Berger;  D. Bhattacharjee;  G. Billingsley;  S. Biscans;  R. M. Blair;  N. Bode;  P. Booker;  R. Bork;  A. Bramley;  K. C. Cannon;  X. Chen;  A. A. Ciobanu;  F. Clara;  C. M. Compton;  S. J. Cooper;  K. R. Corley;  S. T. Countryman;  P. B. Covas;  D. C. Coyne;  L. E. H. Datrier;  D. Davis;  C. Di Fronzo;  K. L. Dooley;  P. Dupej;  T. Etzel;  M. Evans;  T. M. Evans;  J. Feicht;  P. Fulda;  M. Fyffe;  J. A. Giaime;  K. D. Giardina;  P. Godwin;  E. Goetz;  S. Gras;  C. Gray;  R. Gray;  A. C. Green;  E. K. Gustafson;  R. Gustafson;  J. Hanks;  J. Hanson;  R. K. Hasskew;  M. C. Heintze;  A. F. Helmling-Cornell;  N. A. Holland;  J. D. Jones;  S. Kandhasamy;  S. Karki;  P. J. King;  Rahul Kumar;  M. Landry;  B. B. Lane;  B. Lantz;  M. Laxen;  Y. K. Lecoeuche;  J. Leviton;  J. Liu;  M. Lormand;  A. P. Lundgren;  R. Macas;  M. MacInnis;  D. M. Macleod;  S. Márka;  Z. Márka;  D. V. Martynov;  K. Mason;  T. J. Massinger;  R. McCarthy;  D. E. McClelland;  S. McCormick;  J. McIver;  G. Mendell;  K. Merfeld;  E. L. Merilh;  F. Meylahn;  T. Mistry;  R. Mittleman;  G. Moreno;  C. M. Mow-Lowry;  S. Mozzon;  T. J. N. Nelson;  P. Nguyen;  L. K. Nuttall;  J. Oberling;  Richard J. Oram;  C. Osthelder;  D. J. Ottaway;  H. Overmier;  J. R. Palamos;  W. Parker;  E. Payne;  R. Penhorwood;  C. J. Perez;  M. Pirello;  H. Radkins;  K. E. Ramirez;  J. W. Richardson;  K. Riles;  N. A. Robertson;  J. G. Rollins;  C. L. Romel;  J. H. Romie;  M. P. Ross;  K. Ryan;  T. Sadecki;  E. J. Sanchez;  L. E. Sanchez;  T. R. Saravanan;  R. L. Savage;  D. Schaetz;  R. Schnabel;  E. Schwartz;  D. Sellers;  T. Shaffer;  B. J. J. Slagmolen;  J. R. Smith;  S. Soni;  B. Sorazu;  A. P. Spencer;  K. A. Strain;  L. Sun;  M. J. Szczepańczyk;  M. Thomas;  P. Thomas;  K. A. Thorne;  K. Toland;  C. I. Torrie;  G. Traylor;  A. L. Urban;  G. Valdes;  P. J. Veitch;  K. Venkateswara;  G. Venugopalan;  A. D. Viets;  T. Vo;  C. Vorvick;  M. Wade;  R. L. Ward;  J. Warner;  B. Weaver;  R. Weiss;  B. Willke;  C. C. Wipf;  L. Xiao;  H. Yamamoto;  L. Zhang;  M. E. Zucker;  J. Zweizig
收藏  |  浏览/下载：16/0  |  提交时间：2021/06/24
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载：19/0  |  提交时间：2020/12/22
Modeling water quality in watersheds: From here to the next generation 期刊论文
Water Resources Research, 2020
作者:  B. Fu;  J. S. Horsburgh;  A. J. Jakeman;  C. Gualtieri;  T. Arnold;  L. Marshall;  T. R. Green;  N. W. T. Quinn;  M. Volk;  R. J. Hunt;  L. Vezzaro;  B. F. W. Croke;  J. D. Jakeman;  V. Snow;  B. Rashleigh
收藏  |  浏览/下载：10/0  |  提交时间：2020/11/09
Sandy beaches can survive sea-level rise 期刊论文
Nature, 2020
作者:  J. A. G. Cooper;  G. Masselink;  G. Coco;  A. D. Short;  B. Castelle;  K. Rogers;  E. Anthony;  A. N. Green;  J. T. Kelley;  O. H. Pilkey;  D. W. T. Jackson
收藏  |  浏览/下载：7/0  |  提交时间：2020/11/09
Genetic diversity of soil invertebrates corroborates timing estimates for past collapses of the West Antarctic Ice Sheet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Gemma E. Collins;  Ian D. Hogg;  Peter Convey;  Leopoldo G. Sancho;  Don A. Cowan;  W. Berry Lyons;  Byron J. Adams;  Diana H. Wall;  T. G. Allan Green
收藏  |  浏览/下载：8/0  |  提交时间：2020/09/08
Methane emissions from underground gas storage in California 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (4)
作者:  Thorpe, Andrew K.;  Duren, Riley M.;  Conley, Stephen;  Prasad, Kuldeep R.;  Bue, Brian D.;  Yadav, Vineet;  Foster, Kelsey T.;  Rafiq, Talha;  Hopkins, Francesca M.;  Smith, Mackenzie L.;  Fischer, Marc L.;  Thompson, David R.;  Frankenberg, Christian;  McCubbin, Ian B.;  Eastwood, Michael L.;  Green, Robert O.;  Miller, Charles E.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/02
methane  emissions  underground gas storage  Aliso Canyon  temporal variability  imaging spectrometer  
Global plant trait relationships extend to the climatic extremes of the tundra biome 期刊论文
Nature, 2020
作者:  H. J. D. Thomas;  A. D. Bjorkman;  I. H. Myers-Smith;  S. C. Elmendorf;  J. Kattge;  S. Diaz;  M. Vellend;  D. Blok;  J. H. C. Cornelissen;  B. C. Forbes;  G. H. R. Henry;  R. D. Hollister;  S. Normand;  J. S. Prevé;  y;  C. Rixen;  G. Schaepman-Strub;  M. Wilmking;  S. Wipf;  W. K. Cornwell;  P. S. A. Beck;  D. Georges;  S. J. Goetz;  K. C. Guay;  N. Rü;  ger;  N. A. Soudzilovskaia;  M. J. Spasojevic;  J. M. Alatalo;  H. D. Alexander;  A. Anadon-Rosell;  S. Angers-Blondin;  M. te Beest;  L. T. Berner;  R. G. Bjö;  rk;  A. Buchwal;  A. Buras;  M. Carbognani;  K. S. Christie;  L. S. Collier;  E. J. Cooper;  B. Elberling;  A. Eskelinen;  E. R. Frei;  O. Grau;  P. Grogan;  M. Hallinger;  M. M. P. D. Heijmans;  L. Hermanutz;  J. M. G. Hudson;  J. F. Johnstone;  K. Hü;  lber;  M. Iturrate-Garcia;  C. M. Iversen;  F. Jaroszynska;  E. Kaarlejarvi;  A. Kulonen;  L. J. Lamarque;  T. C. Lantz;  E. Lé;  vesque;  C. J. Little;  A. Michelsen;  A. Milbau;  J. Nabe-Nielsen;  S. S. Nielsen;  J. M. Ninot;  S. F. Oberbauer;  J. Olofsson;  V. G. Onipchenko;  A. Petraglia;  S. B. Rumpf;  R. Shetti;  J. D. M. Speed;  K. N. Suding;  K. D. Tape;  M. Tomaselli;  A. J. Trant;  U. A. Treier;  M. Tremblay;  S. E. Venn;  T. Vowles;  S. Weijers;  P. A. Wookey;  T. J. Zamin;  M. Bahn;  B. Blonder;  P. M. van Bodegom;  B. Bond-Lamberty;  G. Campetella;  B. E. L. Cerabolini;  F. S. Chapin;  J. M. Craine;  M. Dainese;  W. A. Green;  S. Jansen;  M. Kleyer;  P. Manning;  Ü;  . Niinemets;  Y. Onoda;  W. A. Ozinga;  J. Peñ;  uelas;  P. Poschlod;  P. B. Reich;  B. Sandel;  B. S. Schamp;  S. N. Sheremetiev;  F. T. de Vries
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.