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Mapping the cellular origin and early evolution of leukemia in Down syndrome 期刊论文
Science, 2021
作者:  Elvin Wagenblast;  Joana Araújo;  Olga I. Gan;  Sarah K. Cutting;  Alex Murison;  Gabriela Krivdova;  Maria Azkanaz;  Jessica L. McLeod;  Sabrina A. Smith;  Blaise A. Gratton;  Sajid A. Marhon;  Martino Gabra;  Jessie J. F. Medeiros;  Sanaz Manteghi;  Jian Chen;  Michelle Chan-Seng-Yue;  Laura Garcia-Prat;  Leonardo Salmena;  Daniel D. De Carvalho;  Sagi Abelson;  Mohamed Abdelhaleem;  Karen Chong;  Maian Roifman;  Patrick Shannon;  Jean C. Y. Wang;  Johann K. Hitzler;  David Chitayat;  John E. Dick;  Eric R. Lechman
收藏  |  浏览/下载:23/0  |  提交时间:2021/07/27
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity 期刊论文
Science, 2021
作者:  Parsa Akbari;  Ankit Gilani;  Olukayode Sosina;  Jack A. Kosmicki;  Lori Khrimian;  Yi-Ya Fang;  Trikaldarshi Persaud;  Victor Garcia;  Dylan Sun;  Alexander Li;  Joelle Mbatchou;  Adam E. Locke;  Christian Benner;  Niek Verweij;  Nan Lin;  Sakib Hossain;  Kevin Agostinucci;  Jonathan V. Pascale;  Ercument Dirice;  Michael Dunn;  Regeneron Genetics Center‡;  DiscovEHR Collaboration‡;  William E. Kraus;  Svati H. Shah;  Yii-Der I. Chen;  Jerome I. Rotter;  Daniel J. Rader;  Olle Melander;  Christopher D. Still;  Tooraj Mirshahi;  David J. Carey;  Jaime Berumen-Campos;  Pablo Kuri-Morales;  Jesus Alegre-Díaz;  Jason M. Torres;  Jonathan R. Emberson;  Rory Collins;  Suganthi Balasubramanian;  Alicia Hawes;  Marcus Jones;  Brian Zambrowicz;  Andrew J. Murphy;  Charles Paulding;  Giovanni Coppola;  John D. Overton;  Jeffrey G. Reid;  Alan R. Shuldiner;  Michael Cantor;  Hyun M. Kang;  Goncalo R. Abecasis;  Katia Karalis;  Aris N. Economides;  Jonathan Marchini;  George D. Yancopoulos;  Mark W. Sleeman;  Judith Altarejos;  Giusy Della Gatta;  Roberto Tapia-Conyer;  Michal L. Schwartzman;  Aris Baras;  Manuel A. R. Ferreira;  Luca A. Lotta
收藏  |  浏览/下载:26/0  |  提交时间:2021/07/27
Tropical Stratospheric Circulation and Ozone Coupled to Pacific Multi-Decadal Variability 期刊论文
Geophysical Research Letters, 2021
作者:  Fernando Iglesias-Suarez;  Oliver Wild;  Douglas E. Kinnison;  Rolando R. Garcia;  Daniel R. Marsh;  Jean-Franç;  ois Lamarque;  Edmund M. Ryan;  Sean M. Davis;  Roland Eichinger;  Alfonso Saiz-Lopez;  Paul J. Young
收藏  |  浏览/下载:12/0  |  提交时间:2021/06/15
Random‐walk Modeling of Reactive Transport in Porous Media With a Reduced‐order Chemical Basis of Conservative Components 期刊论文
Water Resources Research, 2021
作者:  Guillem Sole‐;  Mari;  Michael J. Schmidt;  Diogo Bolster;  Daniel Fernà;  ndez‐;  Garcia
收藏  |  浏览/下载:7/0  |  提交时间:2021/03/29
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver 期刊论文
Science, 2021
作者:  Fotios Sampaziotis;  Daniele Muraro;  Olivia C. Tysoe;  Stephen Sawiak;  Timothy E. Beach;  Edmund M. Godfrey;  Sara S. Upponi;  Teresa Brevini;  Brandon T. Wesley;  Jose Garcia-Bernardo;  Krishnaa Mahbubani;  Giovanni Canu;  Richard Gieseck;  Natalie L. Berntsen;  Victoria L. Mulcahy;  Keziah Crick;  Corrina Fear;  Sharayne Robinson;  Lisa Swift;  Laure Gambardella;  Johannes Bargehr;  Daniel Ortmann;  Stephanie E. Brown;  Anna Osnato;  Michael P. Murphy;  Gareth Corbett;  William T. H. Gelson;  George F. Mells;  Peter Humphreys;  Susan E. Davies;  Irum Amin;  Paul Gibbs;  Sanjay Sinha;  Sarah A. Teichmann;  Andrew J. Butler;  Teik Choon See;  Espen Melum;  Christopher J. E. Watson;  Kourosh Saeb-Parsy;  Ludovic Vallier
收藏  |  浏览/下载:15/0  |  提交时间:2021/02/22
Automatic calibration of groundwater models with bias correction and data filtering: Working with drawdown data 期刊论文
Water Resources Research, 2021
作者:  Michela Trabucchi;  Daniel Fernà;  ndez‐;  Garcia;  Jesú;  s Carrera
收藏  |  浏览/下载:5/0  |  提交时间:2021/02/22
Acidity across the interface from the ocean surface to sea spray aerosol 期刊论文
Proceedings of the National Academy of Science, 2021
作者:  Kyle J. Angle;  Daniel R. Crocker;  Rebecca M. C. Simpson;  Kathryn J. Mayer;  Lauren A. Garofalo;  Alexia N. Moore;  Stephanie L. Mora Garcia;  Victor W. Or;  Sudarshan Srinivasan;  Mahum Farhan;  Jon S. Sauer;  Christopher Lee;  Matson A. Pothier;  Delphine K. Farmer;  Todd R. Martz;  Timothy H. Bertram;  Christopher D. Cappa;  Kimberly A. Prather;  Vicki H. Grassian
收藏  |  浏览/下载:10/0  |  提交时间:2021/01/15
Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:40/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
An Evaluation of the Large-Scale Atmospheric Circulation and Its Variability in CESM2 and Other CMIP Models 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Simpson, Isla R.;  Bacmeister, Julio;  Neale, Richard B.;  Hannay, Cecile;  Gettelman, Andrew;  Garcia, Rolando R.;  Lauritzen, Peter H.;  Marsh, Daniel R.;  Mills, Michael J.;  Medeiros, Brian;  Richter, Jadwiga H.
收藏  |  浏览/下载:17/0  |  提交时间:2020/08/18
CESM2  evaluation  large-scale circulation  extratropical variability  CMIP6  modeling  
Lagrangian modeling of mixing‐limited reactive transport in porous media: multi‐rate interaction by exchange with the mean 期刊论文
Water Resources Research, 2020
作者:  Guillem Sole‐;  Mari;  Daniel Fernà;  ndez‐;  Garcia;  Xavier Sanchez‐;  Vila;  Diogo Bolster
收藏  |  浏览/下载:8/0  |  提交时间:2020/06/09