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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Qian Zhang;  Paul Bastard;  Zhiyong Liu;  Jérémie Le Pen;  Marcela Moncada-Velez;  Jie Chen;  Masato Ogishi;  Ira K. D. Sabli;  Stephanie Hodeib;  Cecilia Korol;  Jérémie Rosain;  Kaya Bilguvar;  Junqiang Ye;  Alexandre Bolze;  Benedetta Bigio;  Rui Yang;  Andrés Augusto Arias;  Qinhua Zhou;  Yu Zhang;  Fanny Onodi;  Sarantis Korniotis;  Léa Karpf;  Quentin Philippot;  Marwa Chbihi;  Lucie Bonnet-Madin;  Karim Dorgham;  Nikaïa Smith;  William M. Schneider;  Brandon S. Razooky;  Hans-Heinrich Hoffmann;  Eleftherios Michailidis;  Leen Moens;  Ji Eun Han;  Lazaro Lorenzo;  Lucy Bizien;  Philip Meade;  Anna-Lena Neehus;  Aileen Camille Ugurbil;  Aurélien Corneau;  Gaspard Kerner;  Peng Zhang;  Franck Rapaport;  Yoann Seeleuthner;  Jeremy Manry;  Cecile Masson;  Yohann Schmitt;  Agatha Schlüter;  Tom Le Voyer;  Taushif Khan;  Juan Li;  Jacques Fellay;  Lucie Roussel;  Mohammad Shahrooei;  Mohammed F. Alosaimi;  Davood Mansouri;  Haya Al-Saud;  Fahd Al-Mulla;  Feras Almourfi;  Saleh Zaid Al-Muhsen;  Fahad Alsohime;  Saeed Al Turki;  Rana Hasanato;  Diederik van de Beek;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D’Angio’;  Paolo Bonfanti;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Andrew J. Oler;  Miranda F. Tompkins;  Camille Alba;  Isabelle Vandernoot;  Jean-Christophe Goffard;  Guillaume Smits;  Isabelle Migeotte;  Filomeen Haerynck;  Pere Soler-Palacin;  Andrea Martin-Nalda;  Roger Colobran;  Pierre-Emmanuel Morange;  Sevgi Keles;  Fatma Çölkesen;  Tayfun Ozcelik;  Kadriye Kart Yasar;  Sevtap Senoglu;  Şemsi Nur Karabela;  Carlos Rodríguez-Gallego;  Giuseppe Novelli;  Sami Hraiech;  Yacine Tandjaoui-Lambiotte;  Xavier Duval;  Cédric Laouénan;  COVID-STORM Clinicians†;  COVID Clinicians†;  Imagine COVID Group†;  French COVID Cohort Study Group†;  CoV-Contact Cohort†;  Amsterdam UMC Covid-19 Biobank†;  COVID Human Genetic Effort†;  NIAID-USUHS/TAGC COVID Immunity Group†;  Andrew L. Snow;  Clifton L. Dalgard;  Joshua D. Milner;  Donald C. Vinh;  Trine H. Mogensen;  Nico Marr;  András N. Spaan;  Bertrand Boisson;  Stéphanie Boisson-Dupuis;  Jacinta Bustamante;  Anne Puel;  Michael J. Ciancanelli;  Isabelle Meyts;  Tom Maniatis;  Vassili Soumelis;  Ali Amara;  Michel Nussenzweig;  Adolfo García-Sastre;  Florian Krammer;  Aurora Pujol;  Darragh Duffy;  Richard P. Lifton;  Shen-Ying Zhang;  Guy Gorochov;  Vivien Béziat;  Emmanuelle Jouanguy;  Vanessa Sancho-Shimizu;  Charles M. Rice;  Laurent Abel;  Luigi D. Notarangelo;  Aurélie Cobat;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载:21/0  |  提交时间:2020/10/26
Autoantibodies against type I IFNs in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Paul Bastard;  Lindsey B. Rosen;  Qian Zhang;  Eleftherios Michailidis;  Hans-Heinrich Hoffmann;  Yu Zhang;  Karim Dorgham;  Quentin Philippot;  Jérémie Rosain;  Vivien Béziat;  Jérémy Manry;  Elana Shaw;  Liis Haljasmägi;  Pärt Peterson;  Lazaro Lorenzo;  Lucy Bizien;  Sophie Trouillet-Assant;  Kerry Dobbs;  Adriana Almeida de Jesus;  Alexandre Belot;  Anne Kallaste;  Emilie Catherinot;  Yacine Tandjaoui-Lambiotte;  Jeremie Le Pen;  Gaspard Kerner;  Benedetta Bigio;  Yoann Seeleuthner;  Rui Yang;  Alexandre Bolze;  András N. Spaan;  Ottavia M. Delmonte;  Michael S. Abers;  Alessandro Aiuti;  Giorgio Casari;  Vito Lampasona;  Lorenzo Piemonti;  Fabio Ciceri;  Kaya Bilguvar;  Richard P. Lifton;  Marc Vasse;  David M. Smadja;  Mélanie Migaud;  Jérome Hadjadj;  Benjamin Terrier;  Darragh Duffy;  Lluis Quintana-Murci;  Diederik van de Beek;  Lucie Roussel;  Donald C. Vinh;  Stuart G. Tangye;  Filomeen Haerynck;  David Dalmau;  Javier Martinez-Picado;  Petter Brodin;  Michel C. Nussenzweig;  Stéphanie Boisson-Dupuis;  Carlos Rodríguez-Gallego;  Guillaume Vogt;  Trine H. Mogensen;  Andrew J. Oler;  Jingwen Gu;  Peter D. Burbelo;  Jeffrey I. Cohen;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D'Angio;  Paolo Bonfanti;  Patrick Rossignol;  Julien Mayaux;  Frédéric Rieux-Laucat;  Eystein S. Husebye;  Francesca Fusco;  Matilde Valeria Ursini;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Riccardo Castagnoli;  Daniela Montagna;  Amelia Licari;  Gian Luigi Marseglia;  Xavier Duval;  Jade Ghosn;  HGID Lab§;  NIAID-USUHS Immune Response to COVID Group§;  COVID Clinicians§;  COVID-STORM Clinicians§;  Imagine COVID Group§;  French COVID Cohort Study Group§;  The Milieu Intérieur Consortium§;  CoV-Contact Cohort§;  Amsterdam UMC Covid-19 Biobank§;  COVID Human Genetic Effort§;  John S. Tsang;  Raphaela Goldbach-Mansky;  Kai Kisand;  Michail S. Lionakis;  Anne Puel;  Shen-Ying Zhang;  Steven M. Holland;  Guy Gorochov;  Emmanuelle Jouanguy;  Charles M. Rice;  Aurélie Cobat;  Luigi D. Notarangelo;  Laurent Abel;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载:14/0  |  提交时间:2020/10/26
Massively parallel coherent laser ranging using a soliton microcomb 期刊论文
NATURE, 2020, 581 (7807) : 164-+
作者:  Casanova, Emmanuelle;  Knowles, Timothy D. J.;  Bayliss, Alex;  Dunne, Julie;  Baranski, Marek Z.;  Denaire, Anthony;  Lefranc, Philippe;  di Lernia, Savino;  Roffet-Salque, Melanie;  Smyth, Jessica;  Barclay, Alistair;  Gillard, Toby;  Classen, Erich;  Coles, Bryony;  Ilett, Michael;  Jeunesse, Christian;  Krueger, Marta;  Marciniak, Arkadiusz;  Minnitt, Steve;  Rotunno, Rocco;  van de Velde, Pieter;  van Wijk, Ivo;  Cotton, Jonathan;  Daykin, Andy;  Evershed, Richard P.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/03

Coherent ranging, also known as frequency-modulated continuous-wave (FMCW) laser-based light detection and ranging (lidar)(1) is used for long-range three-dimensional distance and velocimetry in autonomous driving(2,3). FMCW lidar maps distance to frequency(4,5) using frequency-chirped waveforms and simultaneously measures the Doppler shift of the reflected laser light, similar to sonar or radar(6,7) and coherent detection prevents interference from sunlight and other lidar systems. However, coherent ranging has a lower acquisition speed and requires precisely chirped(8) and highly coherent(5) laser sources, hindering widespread use of the lidar system and impeding parallelization, compared to modern time-of-flight ranging systems that use arrays of individual lasers. Here we demonstrate a massively parallel coherent lidar scheme using an ultra-low-loss photonic chip-based soliton microcomb(9). By fast chirping of the pump laser in the soliton existence range(10) of a microcomb with amplitudes of up to several gigahertz and a sweep rate of up to ten megahertz, a rapid frequency change occurs in the underlying carrier waveform of the soliton pulse stream, but the pulse-to-pulse repetition rate of the soliton pulse stream is retained. As a result, the chirp from a single narrow-linewidth pump laser is transferred to all spectral comb teeth of the soliton at once, thus enabling parallelism in the FMCW lidar. Using this approach we generate 30 distinct channels, demonstrating both parallel distance and velocity measurements at an equivalent rate of three megapixels per second, with the potential to improve sampling rates beyond 150 megapixels per second and to increase the image refresh rate of the FMCW lidar by up to two orders of magnitude without deterioration of eye safety. This approach, when combined with photonic phase arrays(11) based on nanophotonic gratings(12), provides a technological basis for compact, massively parallel and ultrahigh-frame-rate coherent lidar systems.