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Spatial Heterogeneity of Uplift Pattern in the Western European Alps Revealed by InSAR Time-Series Analysis 期刊论文
Geophysical Research Letters, 2021
作者:  M. Mathey;  M.-P. Doin;  P. André;  A. Walpersdorf;  S. Baize;  C. Sue
收藏  |  浏览/下载:7/0  |  提交时间:2022/01/14
No evidence for widespread island extinctions after Pleistocene hominin arrival 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  Julien Louys;  Todd J. Braje;  Chun-Hsiang Chang;  Richard Cosgrove;  Scott M. Fitzpatrick;  Masaki Fujita;  Stuart Hawkins;  Thomas Ingicco;  Ai Kawamura;  Ross D. E. MacPhee;  Matthew C. McDowell;  Hanneke J. M. Meijer;  Philip J. Piper;  Patrick Roberts;  Alan H. Simmons;  Gerrit van den Bergh;  Alexandra van der Geer;  Shimona Kealy;  Sue O’Connor
收藏  |  浏览/下载:11/0  |  提交时间:2021/05/14
Stochastic models support rapid peopling of Late Pleistocene Sahul 期刊论文
Nature Communications, 2021
作者:  Corey J. A. Bradshaw;  Kasih Norman;  Sean Ulm;  Alan N. Williams;  Chris Clarkson;  Joë;  l Chadœ;  uf;  Sam C. Lin;  Zenobia Jacobs;  Richard G. Roberts;  Michael I. Bird;  Laura S. Weyrich;  Simon G. Haberle;  Sue O’;  Connor;  Bastien Llamas;  Tim J. Cohen;  Tobias Friedrich;  Peter Veth;  Matthew Leavesley;  Fré;  ;  rik Saltré
收藏  |  浏览/下载:6/0  |  提交时间:2021/05/07
Rhizosphere ‘Trade’ Is an Unnecessary Analogy: Response to Noë 期刊论文
Trends in Ecology & Evolution\, 2021
作者:  Cindy E. Prescott:Sue J. Grayston:Heljä-Sisko Helmisaari:Eva Kaštovská:Christian Körner:Hans Lambers:Ina C. Meier:Peter Millard:Ivika Ostonen
收藏  |  浏览/下载:8/0  |  提交时间:2021/01/15
Surplus Carbon Drives Allocation and Plant–Soil Interactions 期刊论文
Trends in Ecology & Evolution\, 2020
作者:  Cindy E. Prescott:Sue J. Grayston:Heljä-Sisko Helmisaari:Eva Kaštovská:Christian Körner:Hans Lambers:Ina C. Meier:Peter Millard:Ivika Ostonen
收藏  |  浏览/下载:12/0  |  提交时间:2020/09/14
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Novel approaches to improve estimates of short-lived halocarbon emissions during summer from the Southern Ocean using airborne observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (22) : 14071-14090
作者:  Asher, Elizabeth;  Hornbrook, Rebecca S.;  Stephens, Britton B.;  Kinnison, Doug;  Morgan, Eric J.;  Keeling, Ralph F.;  Atlas, Elliot L.;  Schauffler, Sue M.;  Tilmes, Simone;  Kort, Eric A.;  Hoecker-Martinez, Martin S.;  Long, Matt C.;  Lamarque, Jean-Francois;  Saiz-Lopez, Alfonso;  McKain, Kathryn;  Sweeney, Colm;  Hills, Alan J.;  Apel, Eric C.
收藏  |  浏览/下载:8/0  |  提交时间:2020/02/17
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions (vol 9, 4079, 2018) 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Mancuso, Nicholas;  Gayther, Simon;  Gusev, Alexander;  Zheng, Wei;  Penney, Kathryn L.;  Kote-Jarai, Zsofia;  Eeles, Rosalind;  Freedman, Matthew;  Haiman, Christopher;  Pasaniuc, Bogdan;  Henderson, Brian E.;  Benlloch, Sara;  Schumacher, Fredrick R.;  Al Olama, Ali Amin;  Muir, Kenneth;  Berndt, Sonja I.;  Conti, David V.;  Wiklund, Fredrik;  Chanock, Stephen;  Stevens, Victoria L.;  Tangen, Catherine M.;  Batra, Jyotsna;  Clements, Judith;  Gronberg, Henrik;  Pashayan, Nora;  Schleutker, Johanna;  Albanes, Demetrius;  Weinstein, Stephanie;  Wolk, Alicja;  West, Catharine;  Mucci, Lorelei;  Cancel-Tassin, Geraldine;  Koutros, Stella;  Sorensen, Karina Dalsgaard;  Maehle, Lovise;  Neal, David E.;  Hamdy, Freddie C.;  Donovan, Jenny L.;  Travis, Ruth C.;  Hamilton, Robert J.;  Ingles, Sue Ann;  Rosenstein, Barry;  Lu, Yong-Jie;  Giles, Graham G.;  Kibel, Adam S.;  Vega, Ana;  Kogevinas, Manolis;  Park, Jong Y.;  Stanford, Janet L.;  Cybulski, Cezary;  Nordestgaard, Borge G.;  Brenner, Hermann;  Maier, Christiane;  Kim, Jeri;  John, Esther M.;  Teixeira, Manuel R.;  Neuhausen, Susan L.;  De Ruyck, Kim;  Razack, Azad;  Newcomb, Lisa F.;  Lessel, Davor;  Kaneva, Radka;  Usmani, Nawaid;  Claessens, Frank;  Townsend, Paul A.;  Gago-Dominguez, Manuela;  Roobol, Monique J.;  Menegaux, Florence;  Khaw, Kay-Tee;  Cannon-Albright, Lisa;  Pandha, Hardev;  Thibodeau, Stephen N.;  Hunter, David J.;  Kraft, Peter
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Interpretation of particle number size distributions measured across an urban area during the FASTER campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (1) : 39-55
作者:  Harrison, Roy M.;  Beddows, David C. S.;  Alam, Mohammed S.;  Singh, Ajit;  Brean, James;  Xu, Ruixin;  Kotthaus, Simone;  Grimmond, Sue
收藏  |  浏览/下载:24/0  |  提交时间:2019/04/09
Stratospheric Injection of Brominated Very Short-Lived Substances: Aircraft Observations in the Western Pacific and Representation in Global Models 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (10) : 5690-5719
作者:  Wales, Pamela A.;  Salawitch, Ross J.;  Nicely, Julie M.;  Anderson, Daniel C.;  Canty, Timothy P.;  Baidar, Sunil;  Dix, Barbara;  Koenig, Theodore K.;  Volkamer, Rainer;  Chen, Dexian;  Huey, L. Gregory;  Tanner, David J.;  Cuevas, Carlos A.;  Fernandez, Rafael P.;  Kinnison, Douglas E.;  Lamarque, Jean-Francois;  Saiz-Lopez, Alfonso;  Atlas, Elliot L.;  Hall, Samuel R.;  Navarro, Maria A.;  Pan, Laura L.;  Schauffler, Sue M.;  Stell, Meghan;  Tilmes, Simone;  Ullmann, Kirk;  Weinheimer, Andrew J.;  Akiyoshi, Hideharu;  Chipperfield, Martyn P.;  Deushi, Makoto;  Dhomse, Sandip S.;  Feng, Wuhu;  Graf, Phoebe;  Hossaini, Ryan;  Joeckel, Patrick;  Mancini, Eva;  Michou, Martine;  Morgenstern, Olaf;  Oman, Luke D.;  Pitari, Giovanni;  Plummer, David A.;  Revell, Laura E.;  Rozanov, Eugene;  Saint-Martin, David;  Schofield, Robyn;  Stenke, Andrea;  Stone, Kane A.;  Visioni, Daniele;  Yamashita, Yousuke;  Zeng, Guang
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
bromine  CONTRAST  CCMI  VSLS