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STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity 期刊论文
Environmental Health Perspectives, 2022
作者:  Joyce V.B. Borba;  Vinicius M. Alves;  Rodolpho C. Braga;  Daniel R. Korn;  Kirsten Overdahl;  Arthur C. Silva;  Steven U.S. Hall;  Erik Overdahl;  Nicole Kleinstreuer;  Judy Strickland;  David Allen;  Carolina Horta Andrade;  Eugene N. Muratov;  Alexander Tropsha
收藏  |  浏览/下载:16/0  |  提交时间:2022/03/01
CATMoS: Collaborative Acute Toxicity Modeling Suite 期刊论文
Environmental Health Perspectives, 2021
作者:  Kamel Mansouri;  Agnes L. Karmaus;  Jeremy Fitzpatrick;  Grace Patlewicz;  Prachi Pradeep;  Domenico Alberga;  Nathalie Alepee;  Timothy E.H. Allen;  Dave Allen;  Vinicius M. Alves;  Carolina H. Andrade;  Tyler R. Auernhammer;  Davide Ballabio;  Shannon Bell;  Emilio Benfenati;  Sudin Bhattacharya;  Joyce V. Bastos;  Stephen Boyd;  J.B. Brown;  Stephen J. Capuzzi;  Yaroslav Chushak;  Heather Ciallella;  Alex M. Clark;  Viviana Consonni;  Pankaj R. Daga;  Sean Ekins;  Sherif Farag;  Maxim Fedorov;  Denis Fourches;  Domenico Gadaleta;  Feng Gao;  Jeffery M. Gearhart;  Garett Goh;  Jonathan M. Goodman;  Francesca Grisoni;  Christopher M. Grulke;  Thomas Hartung;  Matthew Hirn;  Pavel Karpov;  Alexandru Korotcov;  Giovanna J. Lavado;  Michael Lawless;  Xinhao Li;  Thomas Luechtefeld;  Filippo Lunghini;  Giuseppe F. Mangiatordi;  Gilles Marcou;  Dan Marsh;  Todd Martin;  Andrea Mauri;  Eugene N. Muratov;  Glenn J. Myatt;  Dac-Trung Nguyen;  Orazio Nicolotti;  Reine Note;  Paritosh Pande;  Amanda K. Parks;  Tyler Peryea;  Ahsan H. Polash;  Robert Rallo;  Alessandra Roncaglioni;  Craig Rowlands;  Patricia Ruiz;  Daniel P. Russo;  Ahmed Sayed;  Risa Sayre;  Timothy Sheils;  Charles Siegel;  Arthur C. Silva;  Anton Simeonov;  Sergey Sosnin;  Noel Southall;  Judy Strickland;  Yun Tang;  Brian Teppen;  Igor V. Tetko;  Dennis Thomas;  Valery Tkachenko;  Roberto Todeschini;  Cosimo Toma;  Ignacio Tripodi;  Daniela Trisciuzzi;  Alexander Tropsha;  Alexandre Varnek;  Kristijan Vukovic;  Zhongyu Wang;  Liguo Wang;  Katrina M. Waters;  Andrew J. Wedlake;  Sanjeeva J. Wijeyesakere;  Dan Wilson;  Zijun Xiao;  Hongbin Yang;  Gergely Zahoranszky-Kohalmi;  Alexey V. Zakharov;  Fagen F. Zhang;  Zhen Zhang;  Tongan Zhao;  Hao Zhu;  Kimberley M. Zorn;  Warren Casey;  Nicole C. Kleinstreuer
收藏  |  浏览/下载:14/0  |  提交时间:2021/05/07
Highly porous nature of a primitive asteroid revealed by thermal imaging 期刊论文
NATURE, 2020, 579 (7800) : 518-522
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:46/0  |  提交时间:2020/05/13

Carbonaceous (C-type) asteroids(1) are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites(2,3) and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth'  s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR)(4) onboard the spacecraft Hayabusa2(5), indicating that the asteroid'  s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m(-2) s(-0.5) K-1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites(6) and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect(7,8). We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites(6). These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity(9) of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies(10).


Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.


  
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.