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A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载：11/0  |  提交时间：2020/12/22
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly 期刊论文
SCIENCE, 2017, 358 (6365) : 933-+
作者:  Yuan, Ling;  Huang, Xing-Yao;  Liu, Zhong-Yu;  Zhang, Feng;  Zhu, Xing-Liang;  Yu, Jiu-Yang;  Ji, Xue;  Xu, Yan-Peng;  Li, Guanghui;  Li, Cui;  Wang, Hong-Jiang;  Deng, Yong-Qiang;  Wu, Menghua;  Cheng, Meng-Li;  Ye, Qing;  Xie, Dong-Yang;  Li, Xiao-Feng;  Wang, Xiangxi;  Shi, Weifeng;  Hu, Baoyang;  Shi, Pei-Yong;  Xu, Zhiheng;  Qin, Cheng-Feng
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Ground-to-satellite quantum teleportation 期刊论文
NATURE, 2017, 549 (7670) : 70-+
作者:  Ren, Ji-Gang;  Xu, Ping;  Yong, Hai-Lin;  Zhang, Liang;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Yang, Meng;  Li, Li;  Yang, Kui-Xing;  Han, Xuan;  Yao, Yong-Qiang;  Li, Ji;  Wu, Hai-Yan;  Wan, Song;  Liu, Lei;  Liu, Ding-Quan;  Kuang, Yao-Wu;  He, Zhi-Ping;  Shang, Peng;  Guo, Cheng;  Zheng, Ru-Hua;  Tian, Kai;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Lu, Chao-Yang;  Shu, Rong;  Chen, Yu-Ao;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27