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DOI | 10.1126/science.aam7120 |
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly | |
Yuan, Ling1,2; Huang, Xing-Yao3; Liu, Zhong-Yu3; Zhang, Feng1,2; Zhu, Xing-Liang1,2; Yu, Jiu-Yang3; Ji, Xue3; Xu, Yan-Peng3; Li, Guanghui1,2; Li, Cui1,2; Wang, Hong-Jiang3; Deng, Yong-Qiang3; Wu, Menghua4; Cheng, Meng-Li3,5; Ye, Qing3; Xie, Dong-Yang3,5; Li, Xiao-Feng3; Wang, Xiangxi6; Shi, Weifeng7; Hu, Baoyang4; Shi, Pei-Yong8,9; Xu, Zhiheng1,2,10; Qin, Cheng-Feng3 | |
2017-11-17 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6365页码:933-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated multiple substitutions from their Asian ancestor. Here we show that a single serine-to-asparagine substitution [Ser(139)-> Asn(139) (S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. This functional adaption makes ZIKV more virulent to human NPCs, thus contributing to the increased incidence of microcephaly in recent ZIKV epidemics. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000415293000049 |
WOS关键词 | COMPLEX ; CELLS ; MICE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197356 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Chinese Acad Sci, State Key Lab Mol Dev Biol, Ctr Excellence Brain Sci & Intelligence Technol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China; 2.Univ CAS, Beijing 100101, Peoples R China; 3.Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China; 4.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China; 5.Anhui Med Univ, Grad Sch, Hefei 230032, Anhui, Peoples R China; 6.Chinese Acad Sci, Inst Biophys, Natl Lab Macromol, Beijing 100101, Peoples R China; 7.Taishan Med Coll, Shandong Univ Key Lab Etiol & Epidemiol Emerging, Tai An 271000, Shandong, Peoples R China; 8.Univ Texas Med Branch, Dept Biochem & Mol Biol, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA; 9.Univ Texas Med Branch, Dept Pharmacol & Toxicol, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA; 10.Beijing Inst Brain Disorders, Parkinsons Dis Ctr, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, Ling,Huang, Xing-Yao,Liu, Zhong-Yu,et al. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly[J]. SCIENCE,2017,358(6365):933-+. |
APA | Yuan, Ling.,Huang, Xing-Yao.,Liu, Zhong-Yu.,Zhang, Feng.,Zhu, Xing-Liang.,...&Qin, Cheng-Feng.(2017).A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.SCIENCE,358(6365),933-+. |
MLA | Yuan, Ling,et al."A single mutation in the prM protein of Zika virus contributes to fetal microcephaly".SCIENCE 358.6365(2017):933-+. |
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