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Electric field control of superconductivity at the LaAlO3/KTaO3(111) interface 期刊论文
Science, 2021
作者:  Zheng Chen;  Yuan Liu;  Hui Zhang;  Zhongran Liu;  He Tian;  Yanqiu Sun;  Meng Zhang;  Yi Zhou;  Jirong Sun;  Yanwu Xie
收藏  |  浏览/下载:7/0  |  提交时间:2021/05/21
Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop 期刊论文
Science, 2021
作者:  Lu Bai;  Margaux Vienne;  Ling Tang;  Yann Kerdiles;  Marion Etiennot;  Bertrand Escalière;  Justine Galluso;  Haiming Wei;  Rui Sun;  Eric Vivier;  Hui Peng;  Zhigang Tian
收藏  |  浏览/下载:10/0  |  提交时间:2021/04/06
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia 期刊论文
Science, 2020
作者:  Kim S. Robinson;  Daniel Eng Thiam Teo;  Kai Sen Tan;  Gee Ann Toh;  Hsiao Hui Ong;  Chrissie Kaishi Lim;  Kenneth Lay;  Bijin Veonice Au;  Tian Sheng Lew;  Justin Jang Hann Chu;  Vincent Tak Kwong Chow;  De Yun Wang;  Franklin L. Zhong;  Bruno Reversade
收藏  |  浏览/下载:6/0  |  提交时间:2020/12/07
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate 期刊论文
Science, 2020
作者:  Sandhya Bangaru;  Gabriel Ozorowski;  Hannah L. Turner;  Aleksandar Antanasijevic;  Deli Huang;  Xiaoning Wang;  Jonathan L. Torres;  Jolene K. Diedrich;  Jing-Hui Tian;  Alyse D. Portnoff;  Nita Patel;  Michael J. Massare;  John R. Yates;  David Nemazee;  James C. Paulson;  Greg Glenn;  Gale Smith;  Andrew B. Ward
收藏  |  浏览/下载:14/0  |  提交时间:2020/11/30
Global maps of the magnetic field in the solar corona 期刊论文
Science, 2020
作者:  Zihao Yang;  Christian Bethge;  Hui Tian;  Steven Tomczyk;  Richard Morton;  Giulio Del Zanna;  Scott W. McIntosh;  Bidya Binay Karak;  Sarah Gibson;  Tanmoy Samanta;  Jiansen He;  Yajie Chen;  Linghua Wang
收藏  |  浏览/下载:7/0  |  提交时间:2020/08/18
Efficient vertical transport of black carbon in the planetary boundary layer 期刊论文
Geophysical Research Letters, 2020
作者:  Dantong Liu;  Kang Hu;  Delong Zhao;  Shuo Ding;  Yunfei Wu;  Chang Zhou;  Chenjie Yu;  Ping Tian;  Quan Liu;  Kai Bi;  Yangzhou Wu;  Bo Hu;  Dongsheng Ji;  Shaofei Kong;  Bin Ouyang;  Hui He;  Mengyu Huang;  Deping Ding
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/14
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Ion-Scale Flux Rope Observed inside a Hot Flow Anomaly 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Bai, Shi-Chen;  Shi, Quanqi;  Liu, Terry Z.;  Zhang, Hui;  Yue, Chao;  Sun, Wei-Jie;  Tian, Anmin;  Degeling, Alexander W.;  Bortnik, Jacob;  Rae, I. Jonathan;  Wang, Mengmeng
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
Cascade of Internal Wave Energy Catalyzed by Eddy-Topography Interactions in the Deep South China Sea 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (4)
作者:  Hu, Qianwen;  Huang, Xiaodong;  Zhang, Zhiwei;  Zhang, Xiaojiang;  Xu, Xing;  Sun, Hui;  Zhou, Chun;  Zhao, Wei;  Tian, Jiwei
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02