GSTDTAP

浏览/检索结果: 共44条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
CAN THE WORLD MAKE ENOUGH CORONAVIRUS VACCINE? 期刊论文
NATURE, 2020, 580 (7805) : 578-580
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Liu, Mingjie;  Jiang, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


  
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
Very regular high-frequency pulsation modes in young intermediate-mass stars 期刊论文
NATURE, 2020, 581 (7807) : 147-+
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Jiang, Lei;  Liu, Mingjie
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Asteroseismology probes the internal structures of stars by using their natural pulsation frequencies(1). It relies on identifying sequences of pulsation modes that can be compared with theoretical models, which has been done successfully for many classes of pulsators, including low-mass solar-type stars(2), red giants(3), high-mass stars(4) and white dwarfs(5). However, a large group of pulsating stars of intermediate mass-the so-called delta Scuti stars-have rich pulsation spectra for which systematic mode identification has not hitherto been possible(6,7). This arises because only a seemingly random subset of possible modes are excited and because rapid rotation tends to spoil regular patterns(8-10). Here we report the detection of remarkably regular sequences of high-frequency pulsation modes in 60 intermediate-mass main-sequence stars, which enables definitive mode identification. The space motions of some of these stars indicate that they are members of known associations of young stars, as confirmed by modelling of their pulsation spectra.


The pulsation spectra of intermediate-mass stars (so-called delta Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.


  
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tao, Chunhui;  Seyfried, W. E., Jr.;  Lowell, R. P.;  Liu, Yunlong;  Liang, Jin;  Guo, Zhikui;  Ding, Kang;  Zhang, Huatian;  Liu, Jia;  Qiu, Lei;  Egorov, Igor;  Liao, Shili;  Zhao, Minghui;  Zhou, Jianping;  Deng, Xianming;  Li, Huaiming;  Wang, Hanchuang;  Cai, Wei;  Zhang, Guoyin;  Zhou, Hongwei;  Lin, Jian;  Li, Wei
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/13
A transition of atmospheric emissions of particles and gases from on-road heavy-duty trucks 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (3) : 1701-1722
作者:  Zhou, Liyuan;  Hallquist, Asa M.;  Hallquist, Mattias;  Salvador, Christian M.;  Gaita, Samuel M.;  Sjodin, Ake;  Jerksjo, Martin;  Salberg, Hakan;  Wangberg, Ingvar;  Mellqvist, Johan;  Liu, Qianyun;  Lee, Berto P.;  Chan, Chak K.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
The Value of Subseasonal Hydrometeorological Forecasts to Hydropower Operations: How Much Does Preprocessing Matter? 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (12) : 10159-10178
作者:  Anghileri, D.;  Monhart, S.;  Zhou, C.;  Bogner, K.;  Castelletti, A.;  Burlando, P.;  Zappa, M.
收藏  |  浏览/下载:2/0  |  提交时间:2020/02/16
Long-term total OH reactivity measurements in a boreal forest 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 14431-14453
作者:  Praplan, Arnaud P.;  Tykka, Toni;  Chen, Dean;  Boy, Michael;  Taipale, Ditte;  Vakkari, Ville;  Zhou, Putian;  Petaja, Tuukka;  Hellen, Heidi
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17
Fatigue-resistant high-performance elastocaloric materials made by additive manufacturing 期刊论文
SCIENCE, 2019, 366 (6469) : 1116-+
作者:  Hou, Huilong;  Simsek, Emrah;  Ma, Tao;  Johnson, Nathan S.;  Qian, Suxin;  Cisse, Cheikh;  Stasak, Drew;  Al Hasan, Naila;  Zhou, Lin;  Hwang, Yunho;  Radermacher, Reinhard;  Levitas, Valery I.;  Kramer, Matthew J.;  Zaeem, Mohsen Asle;  Stebner, Aaron P.;  Ott, Ryan T.;  Cui, Jun;  Takeuchi, Ichiro
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Wang, Yidong;  Wu, Bingruo;  Lu, Pengfei;  Zhang, Donghong;  Wu, Brian;  Varshney, Shweta;  del Monte-Nieto, Gonzalo;  Zhuang, Zhenwu;  Charafeddine, Rabab;  Kramer, Adam H.;  Sibinga, Nicolas E.;  Frangogiannis, Nikolaos G.;  Kitsis, Richard N.;  Adams, Ralf H.;  Alitalo, Kari;  Sharp, David J.;  Harvey, Richard P.;  Stanley, Pamela;  Zhou, Bin
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Spectral Signatures of Adiabatic Electron Acceleration at Saturn Through Corotation Drift Cancelation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Sun, Y. X.;  Roussos, E.;  Krupp, N.;  Zong, Q. G.;  Kollmann, P.;  Zhou, X. Z.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Saturn  electron  radiation belt  corotation drift resonance  magnetosphere  spectrum