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Global divergent trends of algal blooms detected by satellite during 1982–2018 期刊论文
Global Change Biology, 2022
作者:  Chong Fang;  Kaishan Song;  Hans W Paerl;  Pierre-Andre Jacinthe;  Zhidan Wen;  Ge Liu;  Hui Tao;  Xiaofeng Xu;  Tiit Kutser;  Zongming Wang;  Hongtao Duan;  Kun Shi;  Yingxin Shang;  Lili Lyu;  Sijia Li;  Qian Yang;  Dongmei Lyu;  Dehua Mao;  Baohua Zhang;  Shuai Cheng;  Yunfeng Lyu
收藏  |  浏览/下载:14/0  |  提交时间:2022/02/16
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity 期刊论文
Science, 2021
作者:  Wei Hui;  Lingfeng Chao;  Hui Lu;  Fei Xia;  Qi Wei;  Zhenhuang Su;  Tingting Niu;  Lei Tao;  Bin Du;  Deli Li;  Yue Wang;  He Dong;  Shouwei Zuo;  Bixin Li;  Wei Shi;  Xueqin Ran;  Ping Li;  Hui Zhang;  Zhongbin Wu;  Chenxin Ran;  Lin Song;  Guichuan Xing;  Xingyu Gao;  Jing Zhang;  Yingdong Xia;  Yonghua Chen;  Wei Huang
收藏  |  浏览/下载:21/0  |  提交时间:2021/04/06
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Single-molecule level control of host-guest interactions in metallocycle-C-60 complexes 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Tang, Jian-Hong;  Li, Yueqi;  Wu, Qingqing;  Wang, Zixiao;  Hou, Songjun;  Tang, Kun;  Sun, Yue;  Wang, Hui;  Wang, Heng;  Lu, Cheng;  Wang, Xiang;  Li, Xiaopeng;  Wang, Dong;  Yao, Jiannian;  Lambert, Colin J.;  Tao, Nongjian;  Zhong, Yu-Wu;  Stang, Peter J.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yu, Tao;  Gan, Shucheng;  Zhu, Qingchen;  Dai, Dongfang;  Li, Ni;  Wang, Hui;  Chen, Xiaosong;  Hou, Dan;  Wang, Yan;  Pan, Qiang;  Xu, Jing;  Zhang, Xingli;  Liu, Junli;  Pei, Siyu;  Peng, Chao;  Wu, Ping;  Romano, Simona;  Mao, Chaoming;  Huang, Mingzhu;  Zhu, Xiaodong;  Shen, Kunwei;  Qin, Jun;  Xiao, Yichuan
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Tunable giant magnetoresistance in a single-molecule junction 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yang, Kai;  Chen, Hui;  Pope, Thomas;  Hu, Yibin;  Liu, Liwei;  Wang, Dongfei;  Tao, Lei;  Xiao, Wende;  Fei, Xiangmin;  Zhang, Yu-Yang;  Luo, Hong-Gang;  Du, Shixuan;  Xiang, Tao;  Hofer, Werner A.;  Gao, Hong-Jun
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Double-negative-index ceramic aerogels for thermal superinsulation 期刊论文
SCIENCE, 2019, 363 (6428) : 723-+
作者:  Xu, Xiang;  Zhang, Qiangqiang;  Hao, Menglong;  Hu, Yuan;  Lin, Zhaoyang;  Peng, Lele;  Wang, Tao;  Ren, Xuexin;  Wang, Chen;  Zhao, Zipeng;  Wan, Chengzhang;  Fei, Huilong;  Wang, Lei;  Zhu, Jian;  Sun, Hongtao;  Chen, Wenli;  Du, Tao;  Deng, Biwei;  Cheng, Gary J.;  Shakir, Imran;  Dames, Chris;  Fisher, Timothy S.;  Zhang, Xiang;  Li, Hui;  Huang, Yu;  Duan, Xiangfeng
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Dynamic responses of tree-ring growth to multiple dimensions of drought 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (11) : 5380-5390
作者:  Gao, Shan;  Liu, Ruishun;  Zhou, Tao;  Fang, Wei;  Yi, Chuixiang;  Lu, Ruijie;  Zhao, Xiang;  Luo, Hui
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
cumulative effect  drought dimensions  legacy effect  probabilistic patterns of tree growth  response to drought process  tree-ring  water balance