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Population sequencing data reveal a compendium of mutational processes in the human germ line 期刊论文
Science, 2021
作者:  Vladimir B. Seplyarskiy;  Ruslan A. Soldatov;  Evan Koch;  Ryan J. McGinty;  Jakob M. Goldmann;  Ryan D. Hernandez;  Kathleen Barnes;  Adolfo Correa;  Esteban G. Burchard;  Patrick T. Ellinor;  Stephen T. McGarvey;  Braxton D. Mitchell;  Ramachandran S. Vasan;  Susan Redline;  Edwin Silverman;  Scott T. Weiss;  Donna K. Arnett;  John Blangero;  Eric Boerwinkle;  Jiang He;  Courtney Montgomery;  D. C. Rao;  Jerome I. Rotter;  Kent D. Taylor;  Jennifer A. Brody;  Yii-Der Ida Chen;  Lisa de las Fuentes;  Chii-Min Hwu;  Stephen S. Rich;  Ani W. Manichaikul;  Josyf C. Mychaleckyj;  Nicholette D. Palmer;  Jennifer A. Smith;  Sharon L. R. Kardia;  Patricia A. Peyser;  Lawrence F. Bielak;  Timothy D. O’Connor;  Leslie S. Emery;  NHLBI Trans-Omics for Precision Medicine Consortium‡;  TOPMed Population Genetics Working Group;  Christian Gilissen;  Wendy S. W. Wong;  Peter V. Kharchenko;  Shamil Sunyaev
收藏  |  浏览/下载:13/0  |  提交时间:2021/08/30
Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow 期刊论文
Science, 2021
作者:  H.E.S.S. Collaboration;  H. Abdalla;  F. Aharonian;  F. Ait Benkhali;  E. O. Angüner;  C. Arcaro;  C. Armand;  T. Armstrong;  H. Ashkar;  M. Backes;  V. Baghmanyan;  V. Barbosa Martins;  A. Barnacka;  M. Barnard;  Y. Becherini;  D. Berge;  K. Bernlöhr;  B. Bi;  E. Bissaldi;  M. Böttcher;  C. Boisson;  J. Bolmont;  M. de Bony de Lavergne;  M. Breuhaus;  F. Brun;  P. Brun;  M. Bryan;  M. Büchele;  T. Bulik;  T. Bylund;  S. Caroff;  A. Carosi;  S. Casanova;  T. Chand;  S. Chandra;  A. Chen;  G. Cotter;  M. Curyło;  J. Damascene Mbarubucyeye;  I. D. Davids;  J. Davies;  C. Deil;  J. Devin;  L. Dirson;  A. Djannati-Ataï;  A. Dmytriiev;  A. Donath;  V. Doroshenko;  L. Dreyer;  C. Duffy;  J. Dyks;  K. Egberts;  F. Eichhorn;  S. Einecke;  G. Emery;  J.-P. Ernenwein;  K. Feijen;  S. Fegan;  A. Fiasson;  G. Fichet de Clairfontaine;  G. Fontaine;  S. Funk;  M. Füßling;  S. Gabici;  Y. A. Gallant;  G. Giavitto;  L. Giunti;  D. Glawion;  J. F. Glicenstein;  M.-H. Grondin;  J. Hahn;  M. Haupt;  G. Hermann;  J. A. Hinton;  W. Hofmann;  C. Hoischen;  T. L. Holch;  M. Holler;  M. Hörbe;  D. Horns;  D. Huber;  M. Jamrozy;  D. Jankowsky;  F. Jankowsky;  A. Jardin-Blicq;  V. Joshi;  I. Jung-Richardt;  E. Kasai;  M. A. Kastendieck;  K. Katarzyński;  U. Katz;  D. Khangulyan;  B. Khélifi;  S. Klepser;  W. Kluźniak;  Nu. Komin;  R. Konno;  K. Kosack;  D. Kostunin;  M. Kreter;  G. Lamanna;  A. Lemière;  M. Lemoine-Goumard;  J.-P. Lenain;  F. Leuschner;  C. Levy;  T. Lohse;  I. Lypova;  J. Mackey;  J. Majumdar;  D. Malyshev;  D. Malyshev;  V. Marandon;  P. Marchegiani;  A. Marcowith;  A. Mares;  G. Martí-Devesa;  R. Marx;  G. Maurin;  P. J. Meintjes;  M. Meyer;  A. Mitchell;  R. Moderski;  L. Mohrmann;  A. Montanari;  C. Moore;  P. Morris;  E. Moulin;  J. Muller;  T. Murach;  K. Nakashima;  A. Nayerhoda;  M. de Naurois;  H. Ndiyavala;  J. Niemiec;  L. Oakes;  P. O’Brien;  H. Odaka;  S. Ohm;  L. Olivera-Nieto;  E. de Ona Wilhelmi;  M. Ostrowski;  S. Panny;  M. Panter;  R. D. Parsons;  G. Peron;  B. Peyaud;  Q. Piel;  S. Pita;  V. Poireau;  A. Priyana Noel;  D. A. Prokhorov;  H. Prokoph;  G. Pühlhofer;  M. Punch;  A. Quirrenbach;  S. Raab;  R. Rauth;  P. Reichherzer;  A. Reimer;  O. Reimer;  Q. Remy;  M. Renaud;  F. Rieger;  L. Rinchiuso;  C. Romoli;  G. Rowell;  B. Rudak;  E. Ruiz-Velasco;  V. Sahakian;  S. Sailer;  H. Salzmann;  D. A. Sanchez;  A. Santangelo;  M. Sasaki;  M. Scalici;  J. Schäfer;  F. Schüssler;  H. M. Schutte;  U. Schwanke;  M. Seglar-Arroyo;  M. Senniappan;  A. S. Seyffert;  N. Shafi;  J. N. S. Shapopi;  K. Shiningayamwe;  R. Simoni;  A. Sinha;  H. Sol;  A. Specovius;  S. Spencer;  M. Spir-Jacob;  Ł. Stawarz;  L. Sun;  R. Steenkamp;  C. Stegmann;  S. Steinmassl;  C. Steppa;  T. Takahashi;  T. Tam;  T. Tavernier;  A. M. Taylor;  R. Terrier;  J. H. E. Thiersen;  D. Tiziani;  M. Tluczykont;  L. Tomankova;  M. Tsirou;  R. Tuffs;  Y. Uchiyama;  D. J. van der Walt;  C. van Eldik;  C. van Rensburg;  B. van Soelen;  G. Vasileiadis;  J. Veh;  C. Venter;  P. Vincent;  J. Vink;  H. J. Völk;  Z. Wadiasingh;  S. J. Wagner;  J. Watson;  F. Werner;  R. White;  A. Wierzcholska;  Yu Wun Wong;  A. Yusafzai;  M. Zacharias;  R. Zanin;  D. Zargaryan;  A. A. Zdziarski;  A. Zech;  S. J. Zhu;  J. Zorn;  S. Zouari;  N. Żywucka;  P. Evans;  K. Page
收藏  |  浏览/下载:29/0  |  提交时间:2021/06/15
The statistical morphology of Saturn’s equatorial energetic neutral atom emission 期刊论文
Geophysical Research Letters, 2021
作者:  J. Kinrade;  A. Bader;  S. V. Badman;  C. Paranicas;  D. G. Mitchell;  D. Constable;  C. S. Arridge;  S. W. H. Cowley;  G. Provan
收藏  |  浏览/下载:5/0  |  提交时间:2021/06/07
Radial Evolution of a CIR: Observations from a Nearly Radially Aligned Event Between Parker Solar Probe and STEREO‐A 期刊论文
Geophysical Research Letters, 2021
作者:  R. C. Allen;  G. C. Ho;  G. M. Mason;  G. Li;  L. K. Jian;  S. K. Vines;  N. A. Schwadron;  C. J. Joyce;  S. D. Bale;  J. W. Bonnell;  A. W. Case;  E. R. Christian;  C. M. S. Cohen;  M. I. Desai;  R. Filwett;  K. Goetz;  P. R. Harvey;  M. E. Hill;  J. C. Kasper;  K. E. Korreck;  D. Lario;  D. Larson;  R. Livi;  R. J. MacDowall;  D. M. Malaspina;  D. J. McComas;  R. McNutt;  D. G. Mitchell;  K. W. Paulson;  M. Pulupa;  N. Raouafi;  M. L. Stevens;  P. L. Whittlesey;  M. Wiedenbeck
收藏  |  浏览/下载:12/0  |  提交时间:2021/01/22
Evidence for Non‐adiabatic Oxygen Energization in the near‐Earth Magnetotail from MMS 期刊论文
Geophysical Research Letters, 2020
作者:  S. T. Bingham;  R. Nikoukar;  I. J. Cohen;  B. H. Mauk;  D. L. Turner;  D. G. Mitchell;  J. L. Burch;  R. G. Gomez;  S. A. Fuselier;  R. B. Torbert
收藏  |  浏览/下载:11/0  |  提交时间:2021/01/22
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载:19/0  |  提交时间:2020/12/22
A long‐lasting auroral spiral rotating around Saturn’s pole 期刊论文
Geophysical Research Letters, 2020
作者:  B. Palmaerts;  Z. H. Yao;  N. Sergis;  R. L. Guo;  D. Grodent;  K. Dialynas;  J.‐;  C. Gerard;  D. G. Mitchell
收藏  |  浏览/下载:13/0  |  提交时间:2020/11/30
The magnetic structure of the subsolar MPB current layer from MAVEN observations: Implications for the Hall electric force 期刊论文
Geophysical Research Letters, 2020
作者:  G. Boscoboinik;  C. Bertucci;  D. Gomez;  L. Morales;  C. Mazelle;  J. Halekas;  J. Gruesbeck;  D. Mitchell;  B. Jakosky;  E. Penou
收藏  |  浏览/下载:10/0  |  提交时间:2020/10/12
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.