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Contributions of aerosol composition and sources to particulate optical properties in a southern coastal city of China 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Tian, Jie;  Wang, Qiyuan;  Han, Yongming;  Ye, Jianhuai;  Wang, Ping;  Pongpiachan, Siwatt;  Ni, Haiyan;  Zhou, Yaqing;  Wang, Meng;  Zhao, Youzhi;  Cao, Junji
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
PM2.5  Light extinction  Chemical composition  Source apportionment  
Reply to Comment by Jie Qin and Teng Wu on "A Modified Particle Filter-Based Data Assimilation Method for a High-Precision 2-D Hydrodynamic Model Considering Spatial-Temporal Variability of Roughness: Simulation of Dam-Break Flood Inundation" 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (3)
作者:  Cao, Yin;  Ye, Yuntao;  Liang, Lili;  Zhao, Hongli;  Jiang, Yunzhong;  Wang, Hao;  Yi, Zhenyan;  Shang, Yizi;  Yan, Dengming
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:142/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Numerical Simulation of the Irrigation Effects on Surface Fluxes and Local Climate in Typical Mountain-Oasis-Desert Systems in the Central Asia Arid Area 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (23) : 12485-12506
作者:  Zhang, Miao;  Luo, Geping;  Cao, Xiaoshu;  Hamdi, Rafiq;  Li, Tao;  Cai, Peng;  Ye, Hui;  He, Huili
收藏  |  浏览/下载:8/0  |  提交时间:2020/02/17
Numerical Simulation of the Irrigation Effects on Surface Fluxes and Local Climate in Typical Mountain-Oasis-Desert Systems in the Central Asia Arid Area 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Zhang, Miao;  Luo, Geping;  Cao, Xiaoshu;  Hamdi, Rafiq;  Li, Tao;  Cai, Peng;  Ye, Hui;  He, Huili
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
Flood and drip irrigations  Irrigation effects  Water-heat interactions  Modified WRF-Noah  
Mechanical-force-induced non-local collective ferroelastic switching in epitaxial lead-titanate thin films 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Lu, Xiaoyan;  Chen, Zuhuang;  Cao, Ye;  Tang, Yunlong;  Xu, Ruijuan;  Saremi, Sahar;  Zhang, Zhan;  You, Lu;  Dong, Yongqi;  Das, Sujit;  Zhang, Hangbo;  Zheng, Limei;  Wu, Huaping;  Lv, Weiming;  Xie, Guoqiang;  Liu, Xingjun;  Li, Jiangyu;  Chen, Lang;  Chen, Long-Qing;  Cao, Wenwu;  Martin, Lane W.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
A Modified Particle Filter-Based Data Assimilation Method for a High-Precision 2-D Hydrodynamic Model Considering Spatial-temporal Variability of Roughness: Simulation of Dam-Break Flood Inundation 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (7) : 6049-6068
作者:  Cao, Yin;  Ye, Yuntao;  Liang, Lili;  Zhao, Hongli;  Jiang, Yunzhong;  Wang, Hao;  Yi, Zhenyan;  Shang, Yizi;  Yan, Dengming
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
High Contribution of Secondary Brown Carbon to Aerosol Light Absorption in the Southeastern Margin of Tibetan Plateau 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (9) : 4962-4970
作者:  Wang, Qiyuan;  Han, Yongming;  Ye, Jianhuai;  Liu, Suixin;  Pongpiachan, Siwatt;  Zhang, Ningning;  Han, Yuemei;  Tian, Jie;  Wu, Cheng;  Long, Xin;  Zhang, Qian;  Zhang, Wenyan;  Zhao, Zhuzi;  Cao, Junji
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yang, Mi;  Li, Chang-Jun;  Sun, Xi;  Guo, Qi;  Xiao, Ye;  Su, Tian;  Tu, Man-Li;  Peng, Hui;  Lu, Qiong;  Liu, Qing;  He, Hong-Bo;  Jiang, Tie-Jian;  Lei, Min-Xiang;  Wan, Mei;  Cao, Xu;  Luo, Xiang-Hang
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
RAP2 mediates mechanoresponses of the Hippo pathway 期刊论文
NATURE, 2018, 560 (7720) : 655-+
作者:  Meng, Zhipeng;  Qiu, Yunjiang;  Lin, Kimberly C.;  Kumar, Aditya;  Placone, Jesse K.;  Fang, Cao;  Wang, Kuei-Chun;  Lu, Shicong;  Pan, Margaret;  Hong, Audrey W.;  Moroishi, Toshiro;  Luo, Min;  Plouffe, Steven W.;  Diao, Yarui;  Ye, Zhen;  Park, Hyun Woo;  Wang, Xiaoqiong;  Yu, Fa-Xing;  Chien, Shu;  Wang, Cun-Yu;  Ren, Bing;  Engler, Adam J.;  Guan, Kun-Liang
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27