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Strain engineering and epitaxial stabilization of halide perovskites 期刊论文
NATURE, 2020, 577 (7789) : 209-+
作者:  Chen, Yimu;  Lei, Yusheng;  Li, Yuheng;  Yu, Yugang;  Cai, Jinze;  Chiu, Ming-Hui;  Rao, Rahul;  Gu, Yue;  Wang, Chunfeng;  Choi, Woojin;  Hu, Hongjie;  Wang, Chonghe;  Li, Yang;  Song, Jiawei;  Zhang, Jingxin;  Qi, Baiyan;  Lin, Muyang;  Zhang, Zhuorui;  Islam, Ahmad E.;  Maruyama, Benji;  Dayeh, Shadi;  Li, Lain-Jong;  Yang, Kesong;  Lo, Yu-Hwa;  Xu, Sheng
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/03

Strain engineering is a powerful tool with which to enhance semiconductor device performance(1,2). Halide perovskites have shown great promise in device applications owing to their remarkable electronic and optoelectronic properties(3-5). Although applying strain to halide perovskites has been frequently attempted, including using hydrostatic pressurization(6-8), electrostriction(9), annealing(10-12), van der Waals force(13), thermal expansion mismatch(14), and heat-induced substrate phase transition(15), the controllable and device-compatible strain engineering of halide perovskites by chemical epitaxy remains a challenge, owing to the absence of suitable lattice-mismatched epitaxial substrates. Here we report the strained epitaxial growth of halide perovskite single-crystal thin films on lattice-mismatched halide perovskite substrates. We investigated strain engineering of a-formamidinium lead iodide (alpha-FAPbI(3)) using both experimental techniques and theoretical calculations. By tailoring the substrate composition-and therefore its lattice parameter-a compressive strain as high as 2.4 per cent is applied to the epitaxial alpha-FAPbI(3) thin film. We demonstrate that this strain effectively changes the crystal structure, reduces the bandgap and increases the hole mobility of alpha-FAPbI(3). Strained epitaxy is also shown to have a substantial stabilization effect on the alpha-FAPbI(3) phase owing to the synergistic effects of epitaxial stabilization and strain neutralization. As an example, strain engineering is applied to enhance the performance of an alpha-FAPbI(3)-based photodetector.


  
A lower X-gate in TASK channels traps inhibitors within the vestibule 期刊论文
NATURE, 2020
作者:  Chen, Tao;  Nomura, Kinya;  Wang, Xiaolin;  Sohrabi, Reza;  Xu, Jin;  Yao, Lingya;  Paasch, Bradley C.;  Ma, Li;  Kremer, James;  Cheng, Yuti;  Zhang, Li;  Wang, Nian;  Wang, Ertao;  Xin, Xiu-Fang;  He, Sheng Yang
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/03

TWIK-related acid-sensitive potassium (TASK) channels-members of the two pore domain potassium (K-2P) channel family-are found in neurons(1), cardiomyocytes(2-4) and vascular smooth muscle cells(5), where they are involved in the regulation of heart rate(6), pulmonary artery tone(5,7), sleep/wake cycles(8) and responses to volatile anaesthetics(8-11). K-2P channels regulate the resting membrane potential, providing background K+ currents controlled by numerous physiological stimuli(12-15). Unlike other K-2P channels, TASK channels are able to bind inhibitors with high affinity, exceptional selectivity and very slow compound washout rates. As such, these channels are attractive drug targets, and TASK-1 inhibitors are currently in clinical trials for obstructive sleep apnoea and atrial fibrillation(16). In general, potassium channels have an intramembrane vestibule with a selectivity filter situated above and a gate with four parallel helices located below  however, the K-2P channels studied so far all lack a lower gate. Here we present the X-ray crystal structure of TASK-1, and show that it contains a lower gate-which we designate as an '  X-gate'  -created by interaction of the two crossed C-terminal M4 transmembrane helices at the vestibule entrance. This structure is formed by six residues ((VLRFMT248)-V-243) that are essential for responses to volatile anaesthetics(10), neurotransmitters(13) and G-protein-coupled receptors(13). Mutations within the X-gate and the surrounding regions markedly affect both the channel-open probability and the activation of the channel by anaesthetics. Structures of TASK-1 bound to two high-affinity inhibitors show that both compounds bind below the selectivity filter and are trapped in the vestibule by the X-gate, which explains their exceptionally low washout rates. The presence of the X-gate in TASK channels explains many aspects of their physiological and pharmacological behaviour, which will be beneficial for the future development and optimization of TASK modulators for the treatment of heart, lung and sleep disorders.


The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.


  
Signatures of self-organized criticality in an ultracold atomic gas (vol 577, pg 481, 2020) 期刊论文
NATURE, 2020, 579 (7800) : E13-E13
作者:  Zhou, Xiaoling;  Feng, Zongqiang;  Zhu, Linli;  Xu, Jianing;  Miyagi, Lowell;  Dong, Hongliang;  Sheng, Hongwei;  Wang, Yanju;  Li, Quan;  Ma, Yanming;  Zhang, Hengzhong;  Yan, Jinyuan;  Tamura, Nobumichi;  Kunz, Martin;  Lutker, Katie;  Huang, Tianlin;  Hughes, Darcy A.;  Huang, Xiaoxu;  Chen, Bin
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

An amendment to this paper has been published and can be accessed via a link at the top of the paper.


  
Cryo-EM structures of the human cation-chloride cotransporter KCC1 期刊论文
SCIENCE, 2019, 366 (6464) : 505-+
作者:  Liu, Si;  Chang, Shenghai;  Han, Binming;  Xu, Lingyi;  Zhang, Mingfeng;  Zhao, Cheng;  Yang, Wei;  Wang, Feng;  Li, Jingyuan;  Delpire, Eric;  Ye, Sheng;  Bai, Xiao-chen;  Guo, Jiangtao
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator 期刊论文
SCIENCE, 2018, 362 (6421) : 1375-+
作者:  Guo, Ang;  Wang, Yihui;  Chen, Biyi;  Wang, Yunhao;  Yuan, Jinxiang;  Zhang, Liyang;  Hall, Duane;  Wu, Jennifer;  Shi, Yun;  Thu, Qi;  Chen, Cheng;  Thiel, William H.;  Than, Xin;  Weiss, Robert M.;  Zhan, Fenghuang;  Musselman, Catherine A.;  Pufall, Miles;  Zhu, Weizhong;  Au, Kin Fai;  Hong, Jiang;  Anderson, Mark E.;  Grueter, Chad E.;  Song, Long-Sheng
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Magnetic hysteresis up to 80 kelvin in a dysprosium metallocene single-molecule magnet 期刊论文
SCIENCE, 2018, 362 (6421) : 1400-+
作者:  Guo, Fu-Sheng;  Day, Benjamin M.;  Chen, Yan-Cong;  Tong, Ming-Liang;  Mansikkamaki, Akseli;  Layfield, Richard A.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Prolonged milk provisioning in a jumping spider 期刊论文
SCIENCE, 2018, 362 (6418) : 1052-+
作者:  Chen, Zhanqi;  Corlett, Richard T.;  Jiao, Xiaoguo;  Liu, Sheng-Jie;  Charles-Dominique, Tristan;  Zhang, Shichang;  Li, Huan;  Lai, Ren;  Long, Chengbo;  Quan, Rui-Chang
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Impacts of species richness on productivity in a large-scale subtropical forest experiment 期刊论文
SCIENCE, 2018, 362 (6410) : 80-+
作者:  Huang, Yuanyuan;  Chen, Yuxin;  Castro-Izaguirre, Nadia;  Baruffol, Martin;  Brezzi, Matteo;  Lang, Anne;  Li, Ying;  Haerdtle, Werner;  von Oheimb, Goddert;  Yang, Xuefei;  Liu, Xiaojuan;  Pei, Kequan;  Both, Sabine;  Yang, Bo;  Eichenberg, David;  Assmann, Thorsten;  Bauhus, Juergen;  Behrens, Thorsten;  Buscot, Francois;  Chen, Xiao-Yong;  Chesters, Douglas;  Ding, Bing-Yang;  Durka, Walter;  Erfmeier, Alexandra;  Fang, Jingyun;  Fischer, Markus;  Guo, Liang-Dong;  Guo, Dali;  Gutknecht, Jessica L. M.;  He, Jin-Sheng;  He, Chun-Ling;  Hector, Andy;  Hoenig, Lydia;  Hu, Ren-Yong;  Klein, Alexandra-Maria;  Kuehn, Peter;  Liang, Yu;  Li, Shan;  Michalski, Stefan;  Scherer-Lorenzen, Michael;  Schmidt, Karsten;  Scholten, Thomas;  Schuldt, Andreas;  Shi, Xuezheng;  Tan, Man-Zhi;  Tang, Zhiyao;  Trogisch, Stefan;  Wang, Zhengwen;  Welk, Erik;  Wirth, Christian;  Wubet, Tesfaye;  Xiang, Wenhua;  Yu, Mingjian;  Yu, Xiao-Dong;  Zhang, Jiayong;  Zhang, Shouren;  Zhang, Naili;  Zhou, Hong-Zhang;  Zhu, Chao-Dong;  Zhu, Li;  Bruelheide, Helge;  Ma, Keping;  Niklaus, Pascal A.;  Schmid, Bernhard
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Morphogen gradient reconstitution reveals Hedgehog pathway design principles 期刊论文
SCIENCE, 2018, 360 (6388) : 543-+
作者:  Li, Pulin;  Markson, Joseph S.;  Wang, Sheng;  Chen, Siheng;  Vachharajani, Vipul;  Elowitz, Michael B.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27