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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Microbiota-targeted maternal antibodies protect neonates from enteric infection 期刊论文
NATURE, 2020, 577 (7791) : 543-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Although maternal antibodies protect newborn babies from infection(1,2), little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice that lack the capacity to produce IgG are protected from infection with the enteric pathogen enterotoxigenic Escherichia coli by maternal natural IgG antibodies against the maternal microbiota when antibodies are delivered either across the placenta or through breast milk. By challenging pups that were fostered by either maternal antibody-sufficient or antibody-deficient dams, we found that IgG derived from breast milk was crucial for protection against mucosal disease induced by enterotoxigenic E. coli. IgG also provides protection against systemic infection by E. coli. Pups used the neonatal Fc receptor to transfer IgG from milk into serum. The maternal commensal microbiota can induce antibodies that recognize antigens expressed by enterotoxigenic E. coli and other Enterobacteriaceae species. Induction of maternal antibodies against a commensal Pantoea species confers protection against enterotoxigenic E. coli in pups. This role of the microbiota in eliciting protective antibodies to a specific neonatal pathogen represents an important host defence mechanism against infection in neonates.


Neonatal mice are protected against infection with the enteric pathogen enterotoxigenic Escherichia coli by maternally derived natural antibodies as well as by maternal commensal microbiota that induce antibodies that recognize antigens expressed by Enterobacteriaceae.


  
Dualities and non-Abelian mechanics 期刊论文
NATURE, 2020, 577 (7792) : 636-+
作者:  Song, Xinyang;  Sun, Ximei;  Oh, Sungwhan F.;  Wu, Meng;  Zhang, Yanbo;  Zheng, Wen;  Geva-Zatorsky, Naama;  Jupp, Ray;  Mathis, Diane;  Benoist, Christophe;  Kasper, Dennis L.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Dualities-mathematical mappings between different systems-can act as hidden symmetries that enable materials design beyond that suggested by crystallographic space groups.


Dualities are mathematical mappings that reveal links between apparently unrelated systems in virtually every branch of physics(1-8). Systems mapped onto themselves by a duality transformation are called self-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet at the critical point. Here we show how dualities can enhance the symmetries of a dynamical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that escape a standard group theory analysis. As an illustration, we consider twisted kagome lattices(9-15), reconfigurable mechanical structures that change shape by means of a collapse mechanism(9). We observe that pairs of distinct configurations along the mechanism exhibit the same vibrational spectrum and related elastic moduli. We show that these puzzling properties arise from a duality between pairs of configurations on either side of a mechanical critical point. The critical point corresponds to a self-dual structure with isotropic elasticity even in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zone. The spectral degeneracy originates from a version of Kramers'  theorem(16,17) in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-dual point. The normal modes of the self-dual systems exhibit non-Abelian geometric phases(18,19) that affect the semiclassical propagation of wavepackets(20), leading to non-commuting mechanical responses. Our results hold promise for holonomic computation(21) and mechanical spintronics by allowing on-the-fly manipulation of synthetic spins carried by phonons.


  
Demonstration of cooling by the Muon Ionization Cooling Experiment 期刊论文
NATURE, 2020, 578 (7793) : 53-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such '  tertiary'  beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams(1-6). Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness(7,8). Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect(9-11). The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced wfootprint(6).


  
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion 期刊论文
SCIENCE, 2019, 366 (6468) : 1013-+
作者:  Leone, Robert D.;  Zhao, Liang;  Englert, Judson M.;  Sun, Im-Meng;  Oh, Min-Hee;  Sun, Im-Hong;  Arwood, Matthew L.;  Bettencourt, Ian A.;  Patel, Chirag H.;  Wen, Jiayu;  Tam, Ada;  Blosser, Richard L.;  Prchalova, Eva;  Alt, Jesse;  Rais, Rana;  Slusher, Barbara S.;  Powell, Jonathan D.
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
Initial growth of the Northern Lhasaplano, Tibetan Plateau in the early Late Cretaceous (ca. 92 Ma) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2019, 131: 1823-1836
作者:  Lai, Wen;  Hu, Xiumian;  Garzanti, Eduardo;  Sun, Gaoyuan;  Garzione, Carmala N.;  Fadel, Marcelle BouDagher;  Ma, Anlin
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
LNK suppresses interferon signaling in melanoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ding, Ling-Wen;  Sun, Qiao-Yang;  Edwards, Jarem J.;  Fernandez, Lucia Torres;  Ran, Xue-Bin;  Zhou, Si-Qin;  Scolyer, Richard A.;  Wilmott, James S.;  Thompson, John F.;  Ngan Doan;  Said, Jonathan W.;  Venkatachalam, Nachiyappan;  Xiao, Jin-Fen;  Loh, Xin-Yi;  Pein, Maren;  Xu, Liang;  Mullins, David W.;  Yang, Henry;  Lin, De-Chen;  Koeffler, H. Phillip
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling 期刊论文
SCIENCE, 2019, 364 (6440) : 545-+
作者:  Choi, Jin Huk;  Zhong, Xue;  McAlpine, William;  Liao, Tzu-Chieh;  Zhang, Duanwu;  Fang, Beibei;  Russell, Jamie;  Ludwig, Sara;  Nair-Gill, Evan;  Zhang, Zhao;  Wang, Kuan-wen;  Misawa, Takuma;  Zhan, Xiaoming;  Choi, Mihwa;  Wang, Tao;  Li, Xiaohong;  Tang, Miao;  Sun, Qihua;  Yu, Liyang;  Murray, Anne R.;  Moresco, Eva Marie Y.;  Beutler, Bruce
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Recent Surface Air Temperature Change over Mainland China Based on an Urbanization-Bias Adjusted Dataset 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (10) : 2691-2705
作者:  Wen, Kangmin;  Ren, Guoyu;  Li, Jiao;  Zhang, Aiying;  Ren, Yuyu;  Sun, Xiubao;  Zhou, Yaqing
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
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