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A 1-year characterization of organic aerosol composition and sources using an extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF) 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7875-7893
作者:  Qi, Lu;  Vogel, Alexander L.;  Esmaeilirad, Sepideh;  Cao, Liming;  Zheng, Jing;  Jaffrezo, Jean-Luc;  Fermo, Paola;  Kasper-Giebl, Anne;  Daellenbach, Kaspar R.;  Chen, Mindong;  Ge, Xinlei;  Baltensperger, Urs;  Prevot, Andre S. H.;  Slowik, Jay G.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Giant anisotropic thermal expansion actuated by thermodynamically assisted reorientation of imidazoliums in a single crystal 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yao, Zi-Shuo;  Guan, Hanxi;  Shiota, Yoshihito;  He, Chun-Ting;  Wang, Xiao-Lei;  Wu, Shu-Qi;  Zheng, Xiaoyan;  Su, Sheng-Qun;  Yoshizawa, Kazunari;  Kong, Xueqian;  Sato, Osamu;  Tao, Jun
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Narrow bandgap oxide nanoparticles coupled with graphene for high performance mid-infrared photodetection 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Yu, Xuechao;  Li, Yangyang;  Hu, Xiaonan;  Zhangg, Daliang;  Tao, Ye;  Liu, Zhixiong;  He, Yongmin;  Haque, Md Azimul;  Liu, Zheng;  Wu, Tom;  Wang, Qi Jie
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Significant reduction of PM2.5 in eastern China due to regional-scale emission control: evidence from SORPES in 2011-2018 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (18) : 11791-11801
作者:  Ding, Aijun;  Huang, Xin;  Nie, Wei;  Chi, Xuguang;  Xu, Zheng;  Zheng, Longfei;  Xu, Zhengning;  Xie, Yuning;  Qi, Ximeng;  Shen, Yicheng;  Sun, Peng;  Wang, Jiaping;  Wang, Lei;  Sun, Jianning;  Yang, Xiu-Qun;  Qin, Wei;  Zhang, Xiangzhi;  Cheng, Wei;  Liu, Weijing;  Pan, Liangbao;  Fu, Congbin
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Spatial distribution of aerosol microphysical and optical properties and direct radiative effect from the China Aerosol Remote Sensing Network 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (18) : 11843-11864
作者:  Che, Huizheng;  Xia, Xiangao;  Zhao, Hujia;  Dubovik, Oleg;  Holben, Brent N.;  Goloub, Philippe;  Cuevas-Agullo, Emilio;  Estelles, Victor;  Wang, Yaqiang;  Zhu, Jun;  Qi, Bing;  Gong, Wei;  Yang, Honglong;  Zhang, Renjian;  Yang, Leiku;  Chen, Jing;  Wang, Hong;  Zheng, Yu;  Gui, Ke;  Zhang, Xiaochun;  Zhang, Xiaoye
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Characteristics and sources of halogenated hydrocarbons in the Yellow River Delta region, northern China 期刊论文
ATMOSPHERIC RESEARCH, 2019, 225: 70-80
作者:  Zheng, Penggang;  Chen, Tianshu;  Dong, Can;  Liu, Yuhong;  Li, Hongyong;  Han, Guangxuan;  Sun, Jingjing;  Wu, Lin;  Gao, Xiaomei;  Wang, Xinfeng;  Qi, Yanbin;  Zhang, Qingzhu;  Wang, Wenxing;  Xue, Likun
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Halocarbons  Yellow River Delta  Oil field  Positive matrix factorization  Montreal Protocol  
Intra-regional transport of black carbon between the south edge of the North China Plain and central China during winter haze episodes 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (7) : 4499-4516
作者:  Zheng, Huang;  Kong, Shaofei;  Wu, Fangqi;  Cheng, Yi;  Niu, Zhenzhen;  Zheng, Shurui;  Yang, Guowei;  Yao, Liquan;  Yan, Qin;  Wu, Jian;  Zheng, Mingming;  Chen, Nan;  Xu, Ke;  Yan, Yingying;  Liu, Dantong;  Zhao, Delong;  Zhao, Tianliang;  Bai, Yongqing;  Li, Shuanglin;  Qi, Shihua
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
Global Distribution of the Oceanic Bottom Mixed Layer Thickness 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (3) : 1547-1554
作者:  Huang, Peng-Qi;  Cen, Xian-Rong;  Lu, Yuan-Zheng;  Guo, Shuang-Xi;  Zhou, Sheng-Qi
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/26