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Population sequencing data reveal a compendium of mutational processes in the human germ line 期刊论文
Science, 2021
作者:  Vladimir B. Seplyarskiy;  Ruslan A. Soldatov;  Evan Koch;  Ryan J. McGinty;  Jakob M. Goldmann;  Ryan D. Hernandez;  Kathleen Barnes;  Adolfo Correa;  Esteban G. Burchard;  Patrick T. Ellinor;  Stephen T. McGarvey;  Braxton D. Mitchell;  Ramachandran S. Vasan;  Susan Redline;  Edwin Silverman;  Scott T. Weiss;  Donna K. Arnett;  John Blangero;  Eric Boerwinkle;  Jiang He;  Courtney Montgomery;  D. C. Rao;  Jerome I. Rotter;  Kent D. Taylor;  Jennifer A. Brody;  Yii-Der Ida Chen;  Lisa de las Fuentes;  Chii-Min Hwu;  Stephen S. Rich;  Ani W. Manichaikul;  Josyf C. Mychaleckyj;  Nicholette D. Palmer;  Jennifer A. Smith;  Sharon L. R. Kardia;  Patricia A. Peyser;  Lawrence F. Bielak;  Timothy D. O’Connor;  Leslie S. Emery;  NHLBI Trans-Omics for Precision Medicine Consortium‡;  TOPMed Population Genetics Working Group;  Christian Gilissen;  Wendy S. W. Wong;  Peter V. Kharchenko;  Shamil Sunyaev
收藏  |  浏览/下载:13/0  |  提交时间:2021/08/30
Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow 期刊论文
Science, 2021
作者:  H.E.S.S. Collaboration;  H. Abdalla;  F. Aharonian;  F. Ait Benkhali;  E. O. Angüner;  C. Arcaro;  C. Armand;  T. Armstrong;  H. Ashkar;  M. Backes;  V. Baghmanyan;  V. Barbosa Martins;  A. Barnacka;  M. Barnard;  Y. Becherini;  D. Berge;  K. Bernlöhr;  B. Bi;  E. Bissaldi;  M. Böttcher;  C. Boisson;  J. Bolmont;  M. de Bony de Lavergne;  M. Breuhaus;  F. Brun;  P. Brun;  M. Bryan;  M. Büchele;  T. Bulik;  T. Bylund;  S. Caroff;  A. Carosi;  S. Casanova;  T. Chand;  S. Chandra;  A. Chen;  G. Cotter;  M. Curyło;  J. Damascene Mbarubucyeye;  I. D. Davids;  J. Davies;  C. Deil;  J. Devin;  L. Dirson;  A. Djannati-Ataï;  A. Dmytriiev;  A. Donath;  V. Doroshenko;  L. Dreyer;  C. Duffy;  J. Dyks;  K. Egberts;  F. Eichhorn;  S. Einecke;  G. Emery;  J.-P. Ernenwein;  K. Feijen;  S. Fegan;  A. Fiasson;  G. Fichet de Clairfontaine;  G. Fontaine;  S. Funk;  M. Füßling;  S. Gabici;  Y. A. Gallant;  G. Giavitto;  L. Giunti;  D. Glawion;  J. F. Glicenstein;  M.-H. Grondin;  J. Hahn;  M. Haupt;  G. Hermann;  J. A. Hinton;  W. Hofmann;  C. Hoischen;  T. L. Holch;  M. Holler;  M. Hörbe;  D. Horns;  D. Huber;  M. Jamrozy;  D. Jankowsky;  F. Jankowsky;  A. Jardin-Blicq;  V. Joshi;  I. Jung-Richardt;  E. Kasai;  M. A. Kastendieck;  K. Katarzyński;  U. Katz;  D. Khangulyan;  B. Khélifi;  S. Klepser;  W. Kluźniak;  Nu. Komin;  R. Konno;  K. Kosack;  D. Kostunin;  M. Kreter;  G. Lamanna;  A. Lemière;  M. Lemoine-Goumard;  J.-P. Lenain;  F. Leuschner;  C. Levy;  T. Lohse;  I. Lypova;  J. Mackey;  J. Majumdar;  D. Malyshev;  D. Malyshev;  V. Marandon;  P. Marchegiani;  A. Marcowith;  A. Mares;  G. Martí-Devesa;  R. Marx;  G. Maurin;  P. J. Meintjes;  M. Meyer;  A. Mitchell;  R. Moderski;  L. Mohrmann;  A. Montanari;  C. Moore;  P. Morris;  E. Moulin;  J. Muller;  T. Murach;  K. Nakashima;  A. Nayerhoda;  M. de Naurois;  H. Ndiyavala;  J. Niemiec;  L. Oakes;  P. O’Brien;  H. Odaka;  S. Ohm;  L. Olivera-Nieto;  E. de Ona Wilhelmi;  M. Ostrowski;  S. Panny;  M. Panter;  R. D. Parsons;  G. Peron;  B. Peyaud;  Q. Piel;  S. Pita;  V. Poireau;  A. Priyana Noel;  D. A. Prokhorov;  H. Prokoph;  G. Pühlhofer;  M. Punch;  A. Quirrenbach;  S. Raab;  R. Rauth;  P. Reichherzer;  A. Reimer;  O. Reimer;  Q. Remy;  M. Renaud;  F. Rieger;  L. Rinchiuso;  C. Romoli;  G. Rowell;  B. Rudak;  E. Ruiz-Velasco;  V. Sahakian;  S. Sailer;  H. Salzmann;  D. A. Sanchez;  A. Santangelo;  M. Sasaki;  M. Scalici;  J. Schäfer;  F. Schüssler;  H. M. Schutte;  U. Schwanke;  M. Seglar-Arroyo;  M. Senniappan;  A. S. Seyffert;  N. Shafi;  J. N. S. Shapopi;  K. Shiningayamwe;  R. Simoni;  A. Sinha;  H. Sol;  A. Specovius;  S. Spencer;  M. Spir-Jacob;  Ł. Stawarz;  L. Sun;  R. Steenkamp;  C. Stegmann;  S. Steinmassl;  C. Steppa;  T. Takahashi;  T. Tam;  T. Tavernier;  A. M. Taylor;  R. Terrier;  J. H. E. Thiersen;  D. Tiziani;  M. Tluczykont;  L. Tomankova;  M. Tsirou;  R. Tuffs;  Y. Uchiyama;  D. J. van der Walt;  C. van Eldik;  C. van Rensburg;  B. van Soelen;  G. Vasileiadis;  J. Veh;  C. Venter;  P. Vincent;  J. Vink;  H. J. Völk;  Z. Wadiasingh;  S. J. Wagner;  J. Watson;  F. Werner;  R. White;  A. Wierzcholska;  Yu Wun Wong;  A. Yusafzai;  M. Zacharias;  R. Zanin;  D. Zargaryan;  A. A. Zdziarski;  A. Zech;  S. J. Zhu;  J. Zorn;  S. Zouari;  N. Żywucka;  P. Evans;  K. Page
收藏  |  浏览/下载:32/0  |  提交时间:2021/06/15
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载:19/0  |  提交时间:2020/12/22
Increasing decision relevance of ecosystem service science 期刊论文
Nature, 2020
作者:  Lisa Mandle;  Analisa Shields-Estrada;  Rebecca Chaplin-Kramer;  Matthew G. E. Mitchell;  Leah L. Bremer;  Jesse D. Gourevitch;  Peter Hawthorne;  Justin A. Johnson;  Brian E. Robinson;  Jeffrey R. Smith;  Laura J. Sonter;  Gregory M. Verutes;  Adrian L. Vogl;  Gretchen C. Daily;  Taylor H. Ricketts
收藏  |  浏览/下载:13/0  |  提交时间:2020/10/20
Highly porous nature of a primitive asteroid revealed by thermal imaging 期刊论文
NATURE, 2020, 579 (7800) : 518-522
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:48/0  |  提交时间:2020/05/13

Carbonaceous (C-type) asteroids(1) are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites(2,3) and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth'  s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR)(4) onboard the spacecraft Hayabusa2(5), indicating that the asteroid'  s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m(-2) s(-0.5) K-1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites(6) and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect(7,8). We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites(6). These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity(9) of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies(10).


Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.


  
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
Probing the energetic particle environment near the Sun 期刊论文
Nature, 2019, 576: 223-227
作者:  D. J. McComas;  E. R. Christian;  C. M. S. Cohen;  A. C. Cummings;  A. J. Davis;  M. I. Desai;  J. Giacalone;  M. E. Hill;  C. J. Joyce;  S. M. Krimigis;  A. W. Labrador;  R. A. Leske;  O. Malandraki;  W. H. Matthaeus;  R. L. McNutt Jr;  R. A. Mewaldt;  D. G. Mitchell;  A. Posner;  J. S. Rankin;  E. C. Roelof;  N. A. Schwadron;  E. C. Stone;  J. R. Szalay;  M. E. Wiedenbeck;  S. D. Bale;  J. C. Kasper;  A. W. Case;  K. E. Korreck;  R. J. MacDowall;  M. Pulupa;  M. L. Stevens;  A. P. Rouillard
收藏  |  浏览/下载:14/0  |  提交时间:2020/04/16
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Zekavat, Seyedeh M.;  Ruotsalainen, Sanni;  Handsaker, Robert E.;  Alver, Maris;  Bloom, Jonathan;  Poterba, Timothy;  Seed, Cotton;  Ernst, Jason;  Chaffin, Mark;  Engreitz, Jesse;  Peloso, Gina M.;  Manichaikul, Ani;  Yang, Chaojie;  Ryan, Kathleen A.;  Fu, Mao;  Johnson, W. Craig;  Tsai, Michael;  Budoff, Matthew;  Ramachandran, Vasan S.;  Cupples, L. Adrienne;  Rotter, Jerome I.;  Rich, Stephen S.;  Post, Wendy;  Mitchell, Braxton D.;  Correa, Adolfo;  Metspalu, Andres;  Wilson, James G.;  Salomaa, Veikko;  Kellis, Manolis;  Daly, Mark J.;  Neale, Benjamin M.;  McCarroll, Steven;  Surakka, Ida;  Esko, Tonu;  Ganna, Andrea;  Ripatti, Samuli;  Kathiresan, Sekar;  Natarajan, Pradeep
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27