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Radiative forcing of the aerosol-cloud interaction in seriously polluted East China and East China Sea 期刊论文
Atmospheric Research, 2020
作者:  Xiao Zhang, Hong Wang, Hui-Zheng Che, Sai-Chun Tan, ... Guang-Yu Shi
收藏  |  浏览/下载：12/0  |  提交时间：2020/12/07
Impacts of PBL schemes on PM2.5 simulation and their responses to aerosol-radiation feedback in GRAPES_CUACE model during severe haze episodes in Jing-Jin-Ji, China 期刊论文
Atmospheric Research, 2020
作者:  Yue Peng, Hong Wang, Xiaoye Zhang, Tianliang Zhao, ... Zhaodong Liu
收藏  |  浏览/下载：5/0  |  提交时间：2020/09/22
Source attribution of Arctic black carbon and sulfate aerosols and associated Arctic surface warming during 1980–2018 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Lili Ren, Yang Yang, Hailong Wang, Rudong Zhang, Pinya Wang, and Hong Liao
收藏  |  浏览/下载：6/0  |  提交时间：2020/08/09
Temperature effects on optical properties and chemical composition of secondary organic aerosol derived from n-dodecane 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8123-8137
作者:  Li, Junling;  Wang, Weigang;  Li, Kun;  Zhang, Wenyu;  Peng, Chao;  Zhou, Li;  Shi, Bo;  Chen, Yan;  Liu, Mingyuan;  Li, Hong;  Ge, Maofa
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/21
Why do models perform differently on particulate matter over East Asia? A multi-model intercomparison study for MICS-Asia III 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7393-7410
作者:  Tan, Jiani;  Fu, Joshua S.;  Carmichael, Gregory R.;  Itahashi, Syuichi;  Tao, Zhining;  Huang, Kan;  Dong, Xinyi;  Yamaji, Kazuyo;  Nagashima, Tatsuya;  Wang, Xuemei;  Liu, Yiming;  Lee, Hyo-Jung;  Lin, Chuan-Yao;  Ge, Baozhu;  Kajino, Mizuo;  Zhu, Jia;  Zhang, Meigen;  Liao, Hong;  Wang, Zifa
收藏  |  浏览/下载：13/0  |  提交时间：2020/08/18
Volatile organic compounds and ozone air pollution in an oil production region in northern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 7069-7086
作者:  Chen, Tianshu;  Xue, Likun;  Zheng, Penggang;  Zhang, Yingnan;  Liu, Yuhong;  Sun, Jingjing;  Han, Guangxuan;  Li, Hongyong;  Zhang, Xin;  Li, Yunfeng;  Li, Hong;  Dong, Can;  Xu, Fei;  Zhang, Qingzhu;  Wang, Wenxing
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/22
Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Junfeng;  Li, Jingyi;  Ye, Jianhuai;  Zhao, Jian;  Wu, Yangzhou;  Hu, Jianlin;  Liu, Dantong;  Nie, Dongyang;  Shen, Fuzhen;  Huang, Xiangpeng;  Huang, Dan Dan;  Ji, Dongsheng;  Sun, Xu;  Xu, Weiqi;  Guo, Jianping;  Song, Shaojie;  Qin, Yiming;  Liu, Pengfei;  Turner, Jay R.;  Lee, Hyun Chul;  Hwang, Sungwoo;  Liao, Hong;  Martin, Scot T.;  Zhang, Qi;  Chen, Mindong;  Sun, Yele;  Ge, Xinlei;  Jacob, Daniel J.
收藏  |  浏览/下载：18/0  |  提交时间：2020/06/09
Improvement of snow/haze confusion data gaps in MODIS Dark Target aerosol retrievals in East China 期刊论文
Atmospheric Research, 2020
作者:  Xiao Zhang, Hong Wang, Hui-Zheng Che, Sai-Chun Tan, ... Hu-Jia Zhao
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/01
Interdecadal variation in the frequency of extreme hot events in Northeast China and the possible mechanism 期刊论文
Atmospheric Research, 2020
作者:  Haixu Hong, Jianqi Sun, Huijun Wang
收藏  |  浏览/下载：8/0  |  提交时间：2020/05/25
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.