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The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10414-10421
作者:  Chen, Song-Can;  Sun, Guo-Xin;  Yan, Yu;  Konstantinidis, Konstantinos T.;  Zhang, Si-Yu;  Deng, Ye;  Li, Xiao-Min;  Cui, Hui-Ling;  Musat, Florin;  Popp, Denny;  Rosen, Barry P.;  Zhu, Yong-Guan
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13
arsenic  detoxification  evolution  oxygen  biogeochemistry  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03
Disturbance Extraction for Burst Detection in Water Distribution Networks Using Pressure Measurements 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (5)
作者:  Xu, Weirong;  Zhou, Xiao;  Xin, Kunlun;  Boxall, Joby;  Yan, Hexiang;  Tao, Tao
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
Burst detection  Data-driven method  Disturbance extraction  Isolation forest  Water distribution network  Water loss  
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:142/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Gate-controlled reversible rectifying behaviour in tunnel contacted atomically-thin MoS2 transistor 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Li, Xiao-Xi;  Fan, Zhi-Qiang;  Liu, Pei-Zhi;  Chen, Mao-Lin;  Liu, Xin;  Jia, Chuan-Kun;  Sun, Dong-Ming;  Jiang, Xiang-Wei;  Han, Zheng;  Bouchiat, Vincent;  Guo, Jun-Jie;  Chen, Jian-Hao;  Zhang, Zhi-Dong
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27
High thermoelectric performance in low-cost SnS0.91Se0.09 crystals 期刊论文
SCIENCE, 2019, 365 (6460) : 1418-+
作者:  He, Wenke;  Wang, Dongyang;  Wu, Haijun;  Xiao, Yu;  Zhang, Yang;  He, Dongsheng;  Feng, Yue;  Hao, Yu-Jie;  Dong, Jin-Feng;  Chetty, Raju;  Hao, Lijie;  Chen, Dongfeng;  Qin, Jianfei;  Yang, Qiang;  Li, Xin;  Song, Jian-Ming;  Zhu, Yingcai;  Xu, Wei;  Niu, Changlei;  Li, Xin;  Wang, Guangtao;  Liu, Chang;  Ohta, Michibiro;  Pennycook, Stephen J.;  He, Jiaqing;  Li, Jing-Feng;  Zhao, Li-Dong
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/27
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
LNK suppresses interferon signaling in melanoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ding, Ling-Wen;  Sun, Qiao-Yang;  Edwards, Jarem J.;  Fernandez, Lucia Torres;  Ran, Xue-Bin;  Zhou, Si-Qin;  Scolyer, Richard A.;  Wilmott, James S.;  Thompson, John F.;  Ngan Doan;  Said, Jonathan W.;  Venkatachalam, Nachiyappan;  Xiao, Jin-Fen;  Loh, Xin-Yi;  Pein, Maren;  Xu, Liang;  Mullins, David W.;  Yang, Henry;  Lin, De-Chen;  Koeffler, H. Phillip
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Evolution of the Subauroral Polarization Stream Oscillation During the Severe Geomagnetic Storm on 20 November 2003 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (2) : 599-607
作者:  He, Fei;  Zhang, Xiao-Xin;  Wang, Wenbin;  Pu, Zu-Yin;  Zong, Qiu-Gang;  Yao, Zhonghua;  Wei, Yong;  Ren, Zhi-Peng;  Yue, Xinan;  Liu, Libo;  Wan, Weixing
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy (vol 9, 4972, 2018) 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Geng, Hao;  Xue, Changhui;  Mendonca, Janet;  Sun, Xiao-Xin;  Liu, Qiong;  Reardon, Patrick N.;  Chen, Yingxiao;  Qian, Kendrick;  Hua, Vivian;  Chen, Alice;  Pan, Freddy;  Yuan, Julia;  Dang, Sang;  Beer, Tomasz M.;  Dai, Mu-Shui;  Kachhap, Sushant K.;  Qian, David Z.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27