GSTDTAP

浏览/检索结果: 共174条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
Production Flux and Chemical Characteristics of Spray Aerosol Generated From Raindrop Impact on Seawater and Soil 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Zhou, Kaili;  Wang, Shurong;  Lu, Xiaohui;  Chen, Hong;  Wang, Lin;  Chen, Jianmin;  Yang, Xin;  Wang, Xiaofei
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
spray aerosol  aerosol flux  raindrop impact  
Temperature effects on optical properties and chemical composition of secondary organic aerosol derived from n-dodecane 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8123-8137
作者:  Li, Junling;  Wang, Weigang;  Li, Kun;  Zhang, Wenyu;  Peng, Chao;  Zhou, Li;  Shi, Bo;  Chen, Yan;  Liu, Mingyuan;  Li, Hong;  Ge, Maofa
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/21
Why do models perform differently on particulate matter over East Asia? A multi-model intercomparison study for MICS-Asia III 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7393-7410
作者:  Tan, Jiani;  Fu, Joshua S.;  Carmichael, Gregory R.;  Itahashi, Syuichi;  Tao, Zhining;  Huang, Kan;  Dong, Xinyi;  Yamaji, Kazuyo;  Nagashima, Tatsuya;  Wang, Xuemei;  Liu, Yiming;  Lee, Hyo-Jung;  Lin, Chuan-Yao;  Ge, Baozhu;  Kajino, Mizuo;  Zhu, Jia;  Zhang, Meigen;  Liao, Hong;  Wang, Zifa
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/18
Changes in floral nectar are unlikely adaptive responses to pollinator flight sound 期刊论文
ECOLOGY LETTERS, 2020
作者:  Pyke, Graham H.;  Ren, Zong-Xin;  Trunschke, Judith;  Lunau, Klaus;  Wang, Hong
收藏  |  浏览/下载:8/0  |  提交时间:2020/06/29
Evolution  floral nectar production  nectar sugar concentration  plant adaptation  pollinator behaviour  pollinator flight sound  
Divergent responses of soil organic carbon to afforestation 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Hong, Songbai;  Yin, Guodong;  Piao, Shilong;  Dybzinski, Ray;  Cong, Nan;  Li, Xiangyi;  Wang, Kai;  Penuelas, Josep;  Zeng, Hui;  Chen, Anping
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
Volatile organic compounds and ozone air pollution in an oil production region in northern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 7069-7086
作者:  Chen, Tianshu;  Xue, Likun;  Zheng, Penggang;  Zhang, Yingnan;  Liu, Yuhong;  Sun, Jingjing;  Han, Guangxuan;  Li, Hongyong;  Zhang, Xin;  Li, Yunfeng;  Li, Hong;  Dong, Can;  Xu, Fei;  Zhang, Qingzhu;  Wang, Wenxing
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/22
Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Junfeng;  Li, Jingyi;  Ye, Jianhuai;  Zhao, Jian;  Wu, Yangzhou;  Hu, Jianlin;  Liu, Dantong;  Nie, Dongyang;  Shen, Fuzhen;  Huang, Xiangpeng;  Huang, Dan Dan;  Ji, Dongsheng;  Sun, Xu;  Xu, Weiqi;  Guo, Jianping;  Song, Shaojie;  Qin, Yiming;  Liu, Pengfei;  Turner, Jay R.;  Lee, Hyun Chul;  Hwang, Sungwoo;  Liao, Hong;  Martin, Scot T.;  Zhang, Qi;  Chen, Mindong;  Sun, Yele;  Ge, Xinlei;  Jacob, Daniel J.
收藏  |  浏览/下载:18/0  |  提交时间:2020/06/09
Effects of Groundwater Pumping on Ground Surface Temperature: A Regional Modeling Study in the North China Plain 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (9)
作者:  Yang, Chen;  Li, Hong-Yi;  Fang, Yilin;  Cui, Chixiao;  Wang, Tianye;  Zheng, Chunmiao;  Leung, L. Ruby;  Maxwell, Reed M.;  Zhang, You-Kuan;  Yang, Xiaofan
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02
the North China Plain  groundwater pumping  ground surface temperature  integrated hydrologic modeling  ParFlow  CLM  
Photovoltaic panel cooling by atmospheric water sorption-evaporation cycle 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Li, Renyuan;  Shi, Yusuf;  Wu, Mengchun;  Hong, Seunghyun;  Wang, Peng
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.