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Internal state dynamics shape brainwide activity and foraging behaviour 期刊论文
NATURE, 2020, 577 (7789) : 239-+
作者:  Marques, Joao C.;  Li, Meng;  Schaak, Diane;  Robson, Drew N.;  Li, Jennifer M.
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/03

The brain has persistent internal states that can modulate every aspect of an animal'  s mental experience(1-4). In complex tasks such as foraging, the internal state is dynamic(5-8). Caenorhabditis elegans alternate between local search and global dispersal(5). Rodents and primates exhibit trade-offs between exploitation and exploration(6,7). However, fundamental questions remain about how persistent states are maintained in the brain, which upstream networks drive state transitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and decision-making to govern appropriate behaviour. Here, using tracking microscopy to monitor whole-brain neuronal activity at cellular resolution in freely moving zebrafish larvae(9), we show that zebrafish spontaneously alternate between two persistent internal states during foraging for live prey (Paramecia). In the exploitation state, the animal inhibits locomotion and promotes hunting, generating small, localized trajectories. In the exploration state, the animal promotes locomotion and suppresses hunting, generating long-ranging trajectories that enhance spatial dispersion. We uncover a dorsal raphe subpopulation with persistent activity that robustly encodes the exploitation state. The exploitation-state-encoding neurons, together with a multimodal trigger network that is associated with state transitions, form a stochastically activated nonlinear dynamical system. The activity of this oscillatory network correlates with a global retuning of sensorimotor transformations during foraging that leads to marked changes in both the motivation to hunt for prey and the accuracy of motor sequences during hunting. This work reveals an important hidden variable that shapes the temporal structure of motivation and decision-making.


  
Observation of the Kondo screening cloud 期刊论文
NATURE, 2020, 579 (7798) : 210-+
作者:  Shahnawaz, Mohammad;  Mukherjee, Abhisek;  Pritzkow, Sandra;  Mendez, Nicolas;  Rabadia, Prakruti;  Liu, Xiangan;  Hu, Bo;  Schmeichel, Ann;  Singer, Wolfgang;  Wu, Gang;  Tsai, Ah-Lim;  Shirani, Hamid;  Nilsson, K. Peter R.;  Low, Phillip A.;  Soto, Claudio
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

When a magnetic impurity exists in a metal, conduction electrons form a spin cloud that screens the impurity spin. This basic phenomenon is called the Kondo effect(1,2). Unlike electric-charge screening, the spin-screening cloud(3-6) occurs quantum coherently, forming spin-singlet entanglement with the impurity. Although the spins interact locally around the impurity, the Kondo cloud can theoretically spread out over several micrometres. The cloud has not so far been detected, and so its physical existence-a fundamental aspect of the Kondo effect-remains controversial(7,8). Here we present experimental evidence of a Kondo cloud extending over a length of micrometres, comparable to the theoretical length xi(K). In our device, a Kondo impurity is formed in a quantum dot(2,9-11), coupling on one side to a quasi-one-dimensional channel(12) that houses a Fabry-Perot interferometer of various gate-defined lengths L exceeding one micrometre. When we sweep a voltage on the interferometer end gate-separated by L from the quantum dot-to induce Fabry-Perot oscillations in conductance we observe oscillations in the measured Kondo temperature T-K, which is a signature of the Kondo cloud at distance L. When L is less than xi(K) the T-K oscillation amplitude becomes larger as L becomes smaller, obeying a scaling function of a single parameter L/xi(K), whereas when L is greater than xi(K) the oscillation is much weaker. Our results reveal that xi(K) is the only length parameter associated with the Kondo effect, and that the cloud lies mostly within a length of xi(K). Our experimental method offers a way of detecting the spatial distribution of exotic non-Fermi liquids formed by multiple magnetic impurities or multiple screening channels(13-16) and of studying spin-correlated systems.


  
Mapping urban form and function at city block level using spatial metrics 期刊论文
LANDSCAPE AND URBAN PLANNING, 2017, 167
作者:  Vanderhaegen, Sven;  Canters, Frank
收藏  |  浏览/下载:1/0  |  提交时间:2019/04/09
Urban form  Urban function  Land use  Spatial metrics  Machine learning  Brussels Capital Region  
How to Mend a Fragmented City: a Critique of "Infrastructural Solidarity' 期刊论文
INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, 2017, 41 (1)
作者:  Cesafsky, Laura
收藏  |  浏览/下载:3/0  |  提交时间:2019/04/09
fragmentation  infrastructure  spatial form  transportation  Bruno Latour  Bogota  Colombia  actor-network theory