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Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.


  
Three resampling approaches based on method of fragments for daily-to-subdaily precipitation disaggregation 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38: E1119-E1138
作者:  Li, Xin;  Meshgi, Ali;  Wang, Xuan;  Zhang, Jingjie;  Tay, Serene Hui Xin;  Pijcke, Gerard;  Manocha, Nishtha;  Ong, Matthias;  Manh Tuan Nguyen;  Babovic, Vladan
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/09
method of fragments  precipitation disaggregation  regionalized  resampling  spatial correlation  
Analytical solution for tension-saturated and unsaturated flow from wicking porous pipes in subsurface irrigation: The Kornev-Philip legacies revisited 期刊论文
WATER RESOURCES RESEARCH, 2017, 53 (3)
作者:  Kacimov, A. R.;  Obnosov, Yu. V.
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/09
irrigation by siphoning-wicking  method of fragments with continuity of pressure  hydraulic-pressure heads  Laplace  steady-state quasi-linear form of Richards'  equation  Kirchhoff potential