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The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes 期刊论文
NATURE, 2020
作者:  Kindem, Jonathan M.;  Ruskuc, Andrei;  Bartholomew, John G.;  Rochman, Jake;  Huan, Yan Qi;  Faraon, Andrei
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Analysis of Icelandic genomes reveals chromosome fragments of Neanderthal and Denisovan origin, the latter of which occurred through Denisovan gene flow either into ancestors of the Neanderthals or directly into humans.


Human evolutionary history is rich with the interbreeding of divergent populations. Most humans outside of Africa trace about 2% of their genomes to admixture from Neanderthals, which occurred 50-60 thousand years ago(1). Here we examine the effect of this event using 14.4 million putative archaic chromosome fragments that were detected in fully phased whole-genome sequences from 27,566 Icelanders, corresponding to a range of 56,388-112,709 unique archaic fragments that cover 38.0-48.2% of the callable genome. On the basis of the similarity with known archaic genomes, we assign 84.5% of fragments to an Altai or Vindija Neanderthal origin and 3.3% to Denisovan origin  12.2% of fragments are of unknown origin. We find that Icelanders have more Denisovan-like fragments than expected through incomplete lineage sorting. This is best explained by Denisovan gene flow, either into ancestors of the introgressing Neanderthals or directly into humans. A within-individual, paired comparison of archaic fragments with syntenic non-archaic fragments revealed that, although the overall rate of mutation was similar in humans and Neanderthals during the 500 thousand years that their lineages were separate, there were differences in the relative frequencies of mutation types-perhaps due to different generation intervals for males and females. Finally, we assessed 271 phenotypes, report 5 associations driven by variants in archaic fragments and show that the majority of previously reported associations are better explained by non-archaic variants.


  
Ice front blocking of ocean heat transport to an Antarctic ice shelf 期刊论文
NATURE, 2020, 578 (7796) : 568-+
作者:  Alexandrov, Ludmil B.;  Kim, Jaegil;  Haradhvala, Nicholas J.;  Huang, Mi Ni;  Ng, Alvin Wei Tian;  Wu, Yang;  Boot, Arnoud;  Covington, Kyle R.;  Gordenin, Dmitry A.;  Bergstrom, Erik N.;  Islam, S. M. Ashiqul;  Lopez-Bigas, Nuria;  Klimczak, Leszek J.;  McPherson, John R.;  Morganella, Sandro;  Sabarinathan, Radhakrishnan;  Wheeler, David A.;  Mustonen, Ville;  Getz, Gad;  Rozen, Steven G.;  Stratton, Michael R.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13

The front of the Getz Ice Shelf in West Antarctica creates an abrupt topographic step that deflects ocean currents, suppressing 70% of the heat delivery to the ice sheet.


Mass loss from the Antarctic Ice Sheet to the ocean has increased in recent decades, largely because the thinning of its floating ice shelves has allowed the outflow of grounded ice to accelerate(1,2). Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), motivating a recent focus on the processes that control ocean heat transport onto and across the seabed of the Antarctic continental shelf towards the ice(4-6). However, the shoreward heat flux typically far exceeds that required to match observed melt rates(2,7,8), suggesting that other critical controls exist. Here we show that the depth-independent (barotropic) component of the heat flow towards an ice shelf is blocked by the marked step shape of the ice front, and that only the depth-varying (baroclinic) component, which is typically much smaller, can enter the sub-ice cavity. Our results arise from direct observations of the Getz Ice Shelf system and laboratory experiments on a rotating platform. A similar blocking of the barotropic component may occur in other areas with comparable ice-bathymetry configurations, which may explain why changes in the density structure of the water column have been found to be a better indicator of basal melt rate variability than the heat transported onto the continental shelf(9). Representing the step topography of the ice front accurately in models is thus important for simulating ocean heat fluxes and induced melt rates.


  
Combined Effects of Mean Flow and Turbulence on Sediment Pickup Rate 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (2)
作者:  Cheng, N. S.;  Wei, M. X.;  Chiew, Y. M.;  Lu, Y. S.;  Emadzadeh, A.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Sediment pickup rate  densimetric Froude number  turbulence  sediment transport  obstructed flow  
In situ NMR metrology reveals reaction mechanisms in redox flow batteries 期刊论文
NATURE, 2020, 579 (7798) : 224-+
作者:  Ma, Jianfei;  You, Xin;  Sun, Shan;  Wang, Xiaoxiao;  Qin, Song;  Sui, Sen-Fang
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Large-scale energy storage is becoming increasingly critical to balancing renewable energy production and consumption(1). Organic redox flow batteries, made from inexpensive and sustainable redox-active materials, are promising storage technologies that are cheaper and less environmentally hazardous than vanadium-based batteries, but they have shorter lifetimes and lower energy density(2,3). Thus, fundamental insight at the molecular level is required to improve performance(4,5). Here we report two in situ nuclear magnetic resonance (NMR) methods of studying redox flow batteries, which are applied to two redox-active electrolytes: 2,6-dihydroxyanthraquinone (DHAQ) and 4,4 '  -((9,10-anthraquinone-2,6-diyl)dioxy) dibutyrate (DBEAQ). In the first method, we monitor the changes in the H-1 NMR shift of the liquid electrolyte as it flows out of the electrochemical cell. In the second method, we observe the changes that occur simultaneously in the positive and negative electrodes in the full electrochemical cell. Using the bulk magnetization changes (observed via the H-1 NMR shift of the water resonance) and the line broadening of the H-1 shifts of the quinone resonances as a function of the state of charge, we measure the potential differences of the two single-electron couples, identify and quantify the rate of electron transfer between the reduced and oxidized species, and determine the extent of electron delocalization of the unpaired spins over the radical anions. These NMR techniques enable electrolyte decomposition and battery self-discharge to be explored in real time, and show that DHAQ is decomposed electrochemically via a reaction that can be minimized by limiting the voltage used on charging. We foresee applications of these NMR methods in understanding a wide range of redox processes in flow and other electrochemical systems.


  
Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass 期刊论文
NATURE, 2020, 578 (7796) : 559-+
作者:  Papai, Gabor;  Frechard, Alexandre;  Kolesnikova, Olga;  Crucifix, Corinne;  Schultz, Patrick;  Ben-Shem, Adam
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Strain-hardening (the increase of flow stress with plastic strain) is the most important phenomenon in the mechanical behaviour of engineering alloys because it ensures that flow is delocalized, enhances tensile ductility and inhibits catastrophic mechanical failure(1,2). Metallic glasses (MGs) lack the crystallinity of conventional engineering alloys, and some of their properties-such as higher yield stress and elastic strain limit(3)-are greatly improved relative to their crystalline counterparts. MGs can have high fracture toughness and have the highest known '  damage tolerance'  (defined as the product of yield stress and fracture toughness)(4) among all structural materials. However, the use of MGs in structural applications is largely limited by the fact that they show strain-softening instead of strain-hardening  this leads to extreme localization of plastic flow in shear bands, and is associated with early catastrophic failure in tension. Although rejuvenation of an MG (raising its energy to values that are typical of glass formation at a higher cooling rate) lowers its yield stress, which might enable strain-hardening(5), it is unclear whether sufficient rejuvenation can be achieved in bulk samples while retaining their glassy structure. Here we show that plastic deformation under triaxial compression at room temperature can rejuvenate bulk MG samples sufficiently to enable strain-hardening through a mechanism that has not been previously observed in the metallic state. This transformed behaviour suppresses shear-banding in bulk samples in normal uniaxial (tensile or compressive) tests, prevents catastrophic failure and leads to higher ultimate flow stress. The rejuvenated MGs are stable at room temperature and show exceptionally efficient strain-hardening, greatly increasing their potential use in structural applications.


Bulk metallic glasses can acquire the ability to strain-harden through a mechanical rejuvenation treatment at room temperature that retains their non-crystalline structure.


  
Mass balance of the Greenland Ice Sheet from 1992 to 2018 期刊论文
NATURE, 2020, 579 (7798) : 233-+
作者:  Scudellari, Megan
收藏  |  浏览/下载:11/0  |  提交时间:2020/04/16

The Greenland Ice Sheet has been a major contributor to global sea-level rise in recent decades(1,2), and it is expected to continue to be so(3). Although increases in glacier flow(4-6) and surface melting(7-9) have been driven by oceanic(10-12) and atmospheric(13,14) warming, the magnitude and trajectory of the ice sheet'  s mass imbalance remain uncertain. Here we compare and combine 26 individual satellite measurements of changes in the ice sheet'  s volume, flow and gravitational potential to produce a reconciled estimate of its mass balance. The ice sheet was close to a state of balance in the 1990s, but annual losses have risen since then, peaking at 345 +/- 66 billion tonnes per year in 2011. In all, Greenland lost 3,902 +/- 342 billion tonnes of ice between 1992 and 2018, causing the mean sea level to rise by 10.8 +/- 0.9 millimetres. Using three regional climate models, we show that the reduced surface mass balance has driven 1,964 +/- 565 billion tonnes (50.3 per cent) of the ice loss owing to increased meltwater runoff. The remaining 1,938 +/- 541 billion tonnes (49.7 per cent) of ice loss was due to increased glacier dynamical imbalance, which rose from 46 +/- 37 billion tonnes per year in the 1990s to 87 +/- 25 billion tonnes per year since then. The total rate of ice loss slowed to 222 +/- 30 billion tonnes per year between 2013 and 2017, on average, as atmospheric circulation favoured cooler conditions(15) and ocean temperatures fell at the terminus of Jakobshavn Isbr AE(16). Cumulative ice losses from Greenland as a whole have been close to the rates predicted by the Intergovernmental Panel on Climate Change for their high-end climate warming scenario(17), which forecast an additional 70 to 130 millimetres of global sea-level rise by 2100 compared with their central estimate.


  
Volume Flow Rate Estimation for Small Explosions at Mt. Etna, Italy, From Acoustic Waveform Inversion 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Diaz-Moreno, A.;  Iezzi, A. M.;  Lamb, O. D.;  Fee, D.;  Kim, K.;  Zuccarello, L.;  De Angelis, S.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
volcano infrasound  Mt  Etna  waveform inversion  FDTD  volume flow rate  eruption intensity  
Proof-of-Concept Modeling of a New Groundwater Sampling Approach 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (6) : 5135-5146
作者:  Hou, Deyi;  Luo, Jian
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
groundwater sampling  low flow rate  
Dynamics of geologic CO2 storage and plume motion revealed by seismic coda waves 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (7) : 2464-2469
作者:  Tieyuan Zhu;  Jonathan Ajo-Franklin;  Thomas M. Daley;  and Chris Marone
收藏  |  浏览/下载:8/0  |  提交时间:2020/04/16
CO  sequestration  geologic monitoring  coda wave  flow rate  mass quantification  
Wireless Sensing, Monitoring and Optimization for Campus-Wide Steam Distribution 科技报告
来源:US Department of Energy (DOE). 出版年: 2011
作者:  [null]
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/05
Energy efficiency  steam distribution system  wireless sensor networks  state estimation  steam trap diagnostics  flow rate estimation  spectrogram