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Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.


  
Channelization cascade in landscape evolution 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (3) : 1375-1382
作者:  Bonetti, Sara;  Hooshyar, Milad;  Camporeale, Carlo;  Porporato, Amilcare
收藏  |  浏览/下载：15/0  |  提交时间：2020/05/13
ridge and valley patterns  landscape evolution model  detachment limited  river networks  drainage area  
Determining and Modeling Dominant Processes of Interrill Soil Erosion 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (1) : 4-20
作者:  Zhang, X. C.
收藏  |  浏览/下载：12/0  |  提交时间：2019/04/09
interrill erosion process  interrill erosion modeling  raindrop detachment  raindrop-impacted flow transport  
Mechanical Properties of the Sevier Desert Detachment: An Application of Critical Coulomb Wedge Theory 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (15) : 7417-7424
作者:  Yuan, X. P.;  Christie-Blick, N.;  Braun, J.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Sevier Desert detachment  mechanical properties  critical Coulomb wedge theory  compressive and extensional settings  weak materials  fluid overpressure  
Opening of Hess Deep Rift at the Galapagos Triple Junction 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (9) : 3942-3950
作者:  Smith, Deborah K.;  Schouten, Hans
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
seafloor spreading  mid-ocean ridges  oceanic triple junctions  oceanic detachment faults  Galapagos Triple Junction  Galapagos microplate  
Raindrop interaction in interrill erosion for steady rainfalls: A probabilistic approach 期刊论文
WATER RESOURCES RESEARCH, 2017, 53 (5)
作者:  Nouhou Bako, A.;  Darboux, F.;  James, F.;  Lucas, C.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
raindrop  Poisson process  shear stress  detachment  sedimentation  soil erosion  
On factors controlling precursor slip fronts in the laboratory and their relation to slow slip events in nature 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (6)
作者:  Selvadurai, Paul A.;  Glaser, Steven D.;  Parker, Jessica M.
收藏  |  浏览/下载：12/0  |  提交时间：2019/04/09
slow slip evolution  precursory detachment fronts  laboratory friction studies  asperity formations  slow slip events (SSEs)