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世界气象组织发布全球气候数据集更新 快报文章
气候变化快报,2023年第17期
作者:  王田宇 刘燕飞
Microsoft Word(14Kb)  |  收藏  |  浏览/下载:477/0  |  提交时间:2023/09/05
World Meteorological Organization  Climatological Standard Normals  Baseline Update  Data Consolidation  
Zonal Similarity of Long-Term Changes and Seasonal Cycles of Baseline Ozone at Northern Midlatitudes 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Parrish, David D.;  Derwent, Richard G.;  Steinbrecht, Wolfgang;  Stuebi, Rene;  Van Malderen, Roeland;  Steinbacher, Martin;  Trickl, Thomas;  Ries, Ludwig;  Xu, Xiaobin
收藏  |  浏览/下载:12/0  |  提交时间:2020/08/18
baseline ozone  long-term changes  seasonal cycle  zonal similarity  ozone maximum  
Changing risk factors that contribute to premature mortality from ambient air pollution between 2000 and 2015 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Chowdhury, Sourangsu;  Pozzer, Andrea;  Dey, Sagnik;  Klinginuellei, Klaus;  Lelieveld, Jos
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/18
PM2  5  ozone  change in baseline mortality  change in demography  premature mortality  
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.


  
Charting two centuries of transformation in a coastal social-ecological system: A mixed methods approach 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 61
作者:  Thurstan, Ruth H.;  Diggles, Ben K.;  Gillies, Chris L.;  Strong, Michael K.;  Kerkhove, Ray;  Buckley, Sarah M.;  King, Robert A.;  Smythe, Vince;  Heller-Wagner, Gideon;  Weeks, Rebecca;  Palin, Fred;  McLeod, Ian
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
Cultural history  Environmental history  Historical ecology  Moreton Bay  Oyster  Shifting baseline syndrome  
Constraint on the matter-antimatter symmetry-violating phase in neutrino oscillations 期刊论文
NATURE, 2020, 580 (7803) : 339-+
作者:  Houben, Lothar;  Weissman, Haim;  Wolf, Sharon G.;  Rybtchinski, Boris
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

The charge-conjugation and parity-reversal (CP) symmetry of fundamental particles is a symmetry between matter and antimatter. Violation of this CP symmetry was first observed in 1964(1), and CP violation in the weak interactions of quarks was soon established(2). Sakharov proposed(3) that CP violation is necessary to explain the observed imbalance of matter and antimatter abundance in the Universe. However, CP violation in quarks is too small to support this explanation. So far, CP violation has not been observed in non-quark elementary particle systems. It has been shown that CP violation in leptons could generate the matter-antimatter disparity through a process called leptogenesis(4). Leptonic mixing, which appears in the standard model'  s charged current interactions(5,6), provides a potential source of CP violation through a complex phase dCP, which is required by some theoretical models of leptogenesis(7-9). This CP violation can be measured in muon neutrino to electron neutrino oscillations and the corresponding antineutrino oscillations, which are experimentally accessible using accelerator-produced beams as established by the Tokai-to-Kamioka (T2K) and NOvA experiments(10,11). Until now, the value of dCP has not been substantially constrained by neutrino oscillation experiments. Here we report a measurement using long-baseline neutrino and antineutrino oscillations observed by the T2K experiment that shows a large increase in the neutrino oscillation probability, excluding values of dCP that result in a large increase in the observed antineutrino oscillation probability at three standard deviations (3 sigma). The 3 sigma confidence interval for delta(CP), which is cyclic and repeats every 2p, is [-3.41, -0.03] for the so-called normal mass ordering and [-2.54, -0.32] for the inverted mass ordering. Our results indicate CP violation in leptons and our method enables sensitive searches for matter-antimatter asymmetry in neutrino oscillations using accelerator-produced neutrino beams. Future measurements with larger datasets will test whether leptonic CP violation is larger than the CP violation in quarks.


  
More is less: net gain in species richness, but biotic homogenization over 140 years 期刊论文
ECOLOGY LETTERS, 2019, 22 (10) : 1650-1657
作者:  Nielsen, Tora Finderup;  Sand-Jensen, Kaj;  Dornelas, Maria;  Bruun, Hans Henrik
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Baseline  beta diversity  biodiversity  historical ecology  homogenization  landscape  plants  principal coordinates analyses  species composition  species richness  
Elephant effects on treefall and logfall highlight the absence of megaherbivores in coarse woody debris conceptual frameworks 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 438: 57-62
作者:  Landman, Marietjie;  Mgqatsa, Nokubonga;  Cromsigt, Joris P. G. M.;  Kerley, Graham I. H.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Logs  Megafauna extinction  Restoration  Shifting baseline  Treefall  
Rapidly declining remarkability of temperature anomalies may obscure public perception of climate change 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (11) : 4905-4910
作者:  Moore, Frances C.;  Obradovich, Nick;  Lehner, Flavio;  Baylis, Patrick
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
climate change  perception  Twitter  baseline  temperature  
Is agricultural adaptation to global change in lower-income countries on track to meet the future food production challenge? 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2018, 52: 37-48
作者:  Thornton, Philip K.;  Kristjanson, Patricia;  Forch, Wiebke;  Barahona, Carlos;  Cramer, Laura;  Pradhan, Sonali
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Baseline surveys  Household  Site  Characterisation  Agriculture  Adaptation  Enabling environment