GSTDTAP

浏览/检索结果: 共20条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:42/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
The single-cell pathology landscape of breast cancer 期刊论文
NATURE, 2020, 578 (7796) : 615-+
作者:  Fouda, Abdelrahman Y.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Single-cell analyses have revealed extensive heterogeneity between and within human tumours(1-4), but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is the foundation of many clinical decisions. Here we use imaging mass cytometry(5) to simultaneously quantify 35 biomarkers, resulting in 720 high-dimensional pathology images of tumour tissue from 352 patients with breast cancer, with long-term survival data available for 281 patients. Spatially resolved, single-cell analysis identified the phenotypes of tumour and stromal single cells, their organization and their heterogeneity, and enabled the cellular architecture of breast cancer tissue to be characterized on the basis of cellular composition and tissue organization. Our analysis reveals multicellular features of the tumour microenvironment and novel subgroups of breast cancer that are associated with distinct clinical outcomes. Thus, spatially resolved, single-cell analysis can characterize intratumour phenotypic heterogeneity in a disease-relevant manner, with the potential to inform patient-specific diagnosis.


A single-cell, spatially resolved analysis of breast cancer demonstrates the heterogeneity of tumour and stroma tissue and provides a more-detailed method of patient classification than the current histology-based system.


  
Decoding the development of the human hippocampus 期刊论文
NATURE, 2020, 577 (7791) : 531-+
作者:  Zhong, Suijuan;  Ding, Wenyu;  Sun, Le;  Lu, Yufeng;  Dong, Hao;  Fan, Xiaoying;  Liu, Zeyuan;  Chen, Ruiguo;  Zhang, Shu;  Ma, Qiang;  Tang, Fuchou;  Wu, Qian;  Wang, Xiaoqun
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/03

The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory(1,2). Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-seq) analysis to illustrate the cell types, cell linage, molecular features and transcriptional regulation of the developing human hippocampus. Using the transcriptomes of 30,416 cells from the human hippocampus at gestational weeks 16-27, we identify 47 cell subtypes and their developmental trajectories. We also identify the migrating paths and cell lineages of PAX6(+) and HOPX+ hippocampal progenitors, and regional markers of CA1, CA3 and dentate gyrus neurons. Multiomic data have uncovered transcriptional regulatory networks of the dentate gyrus marker PROX1. We also illustrate spatially specific gene expression in the developing human prefrontal cortex and hippocampus. The molecular features of the human hippocampus at gestational weeks 16-20 are similar to those of the mouse at postnatal days 0-5 and reveal gene expression differences between the two species. Transient expression of the primate-specific gene NBPF1 leads to a marked increase in PROX1(+) cells in the mouse hippocampus. These data provides a blueprint for understanding human hippocampal development and a tool for investigating related diseases.


Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.


  
Northern Hemisphere land monsoon precipitation changes in the twentieth century revealed by multiple reanalysis datasets 期刊论文
CLIMATE DYNAMICS, 2019, 53 (11) : 7131-7149
作者:  Huang, Xin;  Zhou, Tianjun;  Zhang, Wenxia;  Jiang, Jie;  Li, Puxi;  Zhao, Yin
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/17
Northern Hemisphere land monsoon rainfall  Long-term changes  Reanalysis data  Moisture budget analysis  
Long-term memory and multifractality of downwelling longwave radiation flux at the Earth's surface 期刊论文
CLIMATE DYNAMICS, 2019, 52: 5723-5738
作者:  Stathopoulos, V. K.;  Matsoukas, C.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Multifractality  Detrended fluctuation analysis  Longwave flux  Long-term memory  
The impact of CO2 mitigation policies on light vehicle fleet in Brazil 期刊论文
ENERGY POLICY, 2019, 126: 370-379
作者:  Benvenutti, Livia M.;  Uriona-Maldonado, Mauricio;  Campos, Lucila M. S.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Light vehicle fleet  CO2 emissions  Mitigation policies  System dynamics  Long-term analysis  Rebound effect  
Regional trends in early-monsoon rainfall over Vietnam and CCSM4 attribution 期刊论文
CLIMATE DYNAMICS, 2019, 52: 363-372
作者:  Li, R.;  Wang, S. S. -Y.;  Gillies, R. R.;  Buckley, B. M.;  Yoon, J. -H.;  Cho, C.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Long-term precipitation trends  Climate regimes of Vietnam  Attribution analysis  Greenhouses gases  Aerosols  Natural forcing  And climate change  
Eighteen-year trends of local and non-local impacts to ambient PM10 in Hong Kong based on chemical speciation and source apportionment 期刊论文
ATMOSPHERIC RESEARCH, 2018, 214: 1-9
作者:  Zhang, Xiaxia;  Yuan, Zibing;  Li, Wenshi;  Lau, Alexis K. H.;  Yu, Jian Zhen;  Fung, Jimmy C. H.;  Zheng, Junyu;  Yu, Alfred L. C.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Long-term trend  Positive matrix factorization  Local and non-local contribution  Backward trajectory cluster analysis  Hong Kong  
Overstory species response to clearcut harvest across environmental gradients in hardwood forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 428: 66-80
作者:  Swaim, J. Travis;  Dey, Daniel C.;  Saunders, Michael R.;  Weigel, Dale R.;  Thornton, Christopher D.;  Kabrick, John M.;  Jenkins, Michael A.
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Long-term data  Stand development  Even-aged  Species composition  Central Hardwood Region  Ordination analysis  Edaphic variables  Disturbance history  
Long-term area-mean temperature series for SwitzerlandCombining homogenized station data and high resolution grid data 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 (6) : 2792-2807
作者:  Begert, Michael;  Frei, Christoph
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
area-mean temperature  climate monitoring  global temperature datasets  long-term climate variations  spatial climate analysis  temperature trend