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Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.


  
Future impacts of environmental factors on achieving the SDG target on child mortality-A synergistic assessment 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2019, 57
作者:  Lucas, Paul L.;  Hilderink, Henk B. M.;  Janssen, Peter H. M.;  Samir, K. C.;  van Vuuren, Detlef P. A.;  Niessen, Louis
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Sustainable development goals  Child mortality  Integrated analysis  Environmental risk  
Climatic Cost-benefit Analysis Under Uncertainty and Learning on Climate Sensitivity and Damages 期刊论文
ECOLOGICAL ECONOMICS, 2018, 154: 99-106
作者:  Ekholm, Tommi
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Climate change  Cost-benefit analysis  Social cost of carbon  Integrated assessment models  Uncertainty  
Examining shrinking city of Detroit in the context of socio-spatial inequalities 期刊论文
LANDSCAPE AND URBAN PLANNING, 2018, 177: 350-361
作者:  Xie, Yichun;  Gong, Hongmian;  Lan, Hai;  Zeng, Shi
收藏  |  浏览/下载:0/0  |  提交时间:2019/04/09
Shrinking city  Socio-spatial inequality  Persistent poverty  Integrated cause and context analysis  
Scarcity in abundance: The challenges of promoting energy access in the Southern African region 期刊论文
ENERGY POLICY, 2018, 120: 110-120
作者:  Diaz-Maurina, Francois;  Chiguvare, Zivayi;  Gope, Gideon
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Integrated analysis  Energy modelling  Scenario assessment  MuSIASEM  Energy poverty  Development  
Connecting the sustainable development goals by their energy inter-linkages 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (3)
作者:  McCollum, David L.;  Echeverri, Luis Gomez;  Busch, Sebastian;  Pachauri, Shonali;  Parkinson, Simon;  Rogelj, Joeri;  Krey, Volker;  minx, Jan C.;  Nilsson, Mans;  Stevance, Anne-Sophie;  Riahi, Keywan
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
energy  sustainable development goals  systems analysis  integrated assessment  
Energy Metabolism of 28 World Countries: A Multi-scale Integrated Analysis 期刊论文
ECOLOGICAL ECONOMICS, 2017, 142
作者:  Andreoni, Valeria
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/09
Exosomatic energy  Social metabolism  Multi-Scale integrated analysis  World Input-Output Database  
Recovery Act. Demonstration of a Pilot Integrated Biorefinery for the Efficient, Direct Conversion of Biomass to Diesel Fuel 科技报告
来源:US Department of Energy (DOE). 出版年: 2015
作者:  Schuetzle, Dennis;  Tamblyn, Greg;  Caldwell, Matt;  Hanbury, Orion;  Schuetzle, Robert;  Rodriguez, Ramer;  Johnson, Alex;  Deichert, Fred;  Jorgensen, Roger;  Struble, Doug
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/05
Biomass  Feedstocks  Rice Hulls  Wood  Renewable Diesel Fuel  Synthetic Diesel Fuel  Renewable Fuels  Reformulated Gasoline Blendstocks  Integrated Biorefinery  Risk Management  Mitigation Analysis  Safety  Health  Plant Engineering  Plant Design  Enginee  
Drivers for the Shipping Sector----Deliverable 1.1 科技报告
来源:Ecologic Institute (EU). 出版年: 2015
作者:  Benjamin Boteler;  Jenny Tröltzsch;  Katrina Abhold;  Dr. Manuel Lago
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/05
shipping  air pollution  water pollution  noise pollution  marine  ecosystem services  MSFD  policy  analysis  scenarios  integrated assessment  evaluation  modelling  Europe  Baltic Sea  
Feasibility Study of Economics and Performance of Solar Photovoltaics at the Standard Chlorine of Delaware Superfund Site in Delaware City, Delaware. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's La 科技报告
来源:US Department of Energy (DOE). 出版年: 2013
作者:  Salasovich, J.;  Geiger, J.;  Mosey, G.;  Healey, V.
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/05
DELAWARE  NEW CASTLE COUNTY  STANDARD CHLORINE  PHOTOVOLTAICS  PV  SOLAR  ECONOMICS  FINANCING  EPA  FEASIBILITY STUDY  NET METERING  JEDI  SAM  SYSTEM ADVISOR MODEL  Solar Energy - Photovoltaics  Energy Analysis  Integrated Applications