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美非营利组织建议中小型排放源利用CCUS枢纽实现脱碳 快报文章
气候变化快报，2024年第2期
作者:  裴惠娟
Microsoft Word(28Kb)  |  收藏  |  浏览/下载：405/0  |  提交时间：2024/01/19
U.S.  CCUS  Hubs  Small-to-Midsize Industrial Emitters  
国际可持续碳中心关注CCUS枢纽与集群对脱碳的贡献 快报文章
气候变化快报，2024年第2期
作者:  裴惠娟
Microsoft Word(26Kb)  |  收藏  |  浏览/下载：401/0  |  提交时间：2024/01/19
CCUS  Hubs  Clusters  
美国启动投资总额达70亿美元的氢能中心建设计划 快报文章
地球科学快报，2023年第20期
作者:  王立伟
Microsoft Word(18Kb)  |  收藏  |  浏览/下载：570/0  |  提交时间：2023/10/25
Clean Hydrogen Hubs  Clean Manufacturing  
美能源部投资49亿美元用于直接空气碳捕集 快报文章
气候变化快报，2023年第17期
作者:  董利苹
Microsoft Word(17Kb)  |  收藏  |  浏览/下载：479/0  |  提交时间：2023/09/05
Biden-Harris Administration  $4.9 Billion  Direct Air Capture Hubs  
美国政府启动总额为5亿美元的矿区清洁能源中心建设项目 快报文章
地球科学快报，2022年第14期
作者:  王立伟
Microsoft Word(14Kb)  |  收藏  |  浏览/下载：670/0  |  提交时间：2022/07/25
Biden Administration  Mines  New Clean Energy Hubs  
美国能源部制定95亿美元清洁氢计划 快报文章
气候变化快报，2022年第05期
作者:  董利苹
Microsoft Word(15Kb)  |  收藏  |  浏览/下载：778/0  |  提交时间：2022/03/04
Clean Hydrogen Initiatives  Bipartisan Infrastructure Law  Regional Clean Hydrogen Hubs  Clean Hydrogen Electrolysis Program  Clean Hydrogen Manufacturing and Recycling Initiatives  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
County-level climate change information to support decision-making on working lands 期刊论文
CLIMATIC CHANGE, 2018, 148 (3) : 355-369
作者:  Elias, Emile;  Schrader, T. Scott;  Abatzoglou, John T.;  James, Darren;  Crimmins, Mike;  Weiss, Jeremy;  Rango, Albert
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Climate change  Decision-making  Agriculture  Forestry  Ranching  USDA climate hubs  Cooperative extension