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An intestinal zinc sensor regulates food intake and developmental growth 期刊论文
NATURE, 2020, 580 (7802) : 263-+
作者:  Wu, Thomas D.;  39;Gorman, William E.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

Hodor, an intestinal zinc-gated chloride channel, controls systemic growth in Drosophila by promoting food intake and by modulating Tor signalling and lysosomal homeostasis within enterocytes.


In cells, organs and whole organisms, nutrient sensing is key to maintaining homeostasis and adapting to a fluctuating environment(1). In many animals, nutrient sensors are found within the enteroendocrine cells of the digestive system  however, less is known about nutrient sensing in their cellular siblings, the absorptive enterocytes(1). Here we use a genetic screen in Drosophila melanogaster to identify Hodor, an ionotropic receptor in enterocytes that sustains larval development, particularly in nutrient-scarce conditions. Experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized dietary preference for zinc. Hodor controls systemic growth from a subset of enterocytes-interstitial cells-by promoting food intake and insulin/IGF signalling. Although Hodor sustains gut luminal acidity and restrains microbial loads, its effect on systemic growth results from the modulation of Tor signalling and lysosomal homeostasis within interstitial cells. Hodor-like genes are insect-specific, and may represent targets for the control of disease vectors. Indeed, CRISPR-Cas9 genome editing revealed that the single hodor orthologue in Anopheles gambiae is an essential gene. Our findings highlight the need to consider the instructive contributions of metals-and, more generally, micronutrients-to energy homeostasis.


  
The need for policies to reduce the costs of cleaner cooking in low income settings: Implications from systematic analysis of costs and benefits 期刊论文
ENERGY POLICY, 2018, 121: 275-285
作者:  Jeuland, Marc;  Soo, Jie-Sheng Tan;  Shindell, Drew
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Cost-benefit analysis  Environment and development  Household air pollution  Climate change mitigation  Improved cookstoves  Subsidies  
Global megatrend update: 6 From a unipolar to a multipolar world 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2013
作者:  European Environment Agency
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/05
Environment  Social and Economic development  Urban zone  - International  
Global megatrend update: 5 Continued economic growth? 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2013
作者:  European Environment Agency
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/05
Environment  Social and Economic development  Urban zone  - International  
Infrastructure for development: meeting the challenge 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2012
作者:  Amar Bhattacharya;  Mattia Romani;  Nicholas Stern
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/05
Social and Economic development  Sustainable development  Environment  Developing countries  - International  
The poverty impacts of climate change: a review of the evidence 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2011
作者:  Emmanuel Skoufias;  Mariano Rabassa;  Sergio Olivieri
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/05
Environment  Poverty and Poverty reduction  Climate change  Climate  Social protection and welfare  Social and Economic development  - International  
From Green Economies to Green Societies: UNESCO's Commitment to Sustainable Development 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2011
作者:  United Nations Educational, Scientific and Cultural Organization
收藏  |  浏览/下载:3/0  |  提交时间:2019/04/05
Environment  Sustainable development  Climate change  Disaster prevention and preparedness  Green economy  - International  
Human Development Report 2011 - Sustainability and equity: a better future for all 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2011
作者:  United Nations Development Programme
收藏  |  浏览/下载:53/0  |  提交时间:2019/04/05
Environment  Sustainable development  Climate change  Social and Economic development  - International  
Climate Change Challenges in ASEAN-facilitated Interventions in the Mekong Subregion 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2010
作者:  Jessica Dator-Bercilla;  Daphne Villanueva;  Alexander C. Chandra;  Trade Knowledge Network
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/05
Environment  Climate change  Sustainable development  Social and Economic development  Region II - Asia  South East Asia