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A noncoding RNA modulator potentiates phenylalanine metabolism in mice 期刊论文
Science, 2021
作者:  Yajuan Li;  Zhi Tan;  Yaohua Zhang;  Zhao Zhang;  Qingsong Hu;  Ke Liang;  Yao Jun;  Youqiong Ye;  Yi-Chuan Li;  Chunlai Li;  Lan Liao;  Jianming Xu;  Zhen Xing;  Yinghong Pan;  Sujash S. Chatterjee;  Tina K. Nguyen;  Heidi Hsiao;  Sergey D. Egranov;  Nagireddy Putluri;  Cristian Coarfa;  David H. Hawke;  Preethi H. Gunaratne;  Kuang-Lei Tsai;  Leng Han;  Mien-Chie Hung;  George A. Calin;  Fares Namour;  Jean-Louis Guéant;  Ania C. Muntau;  Nenad Blau;  V. Reid Sutton;  Manuel Schiff;  François Feillet;  Shuxing Zhang;  Chunru Lin;  Liuqing Yang
收藏  |  浏览/下载:44/0  |  提交时间:2021/08/10
Late lactation in small mammals is a critically sensitive window of vulnerability to elevated ambient temperature 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Zhi-Jun Zhao;  Catherine Hambly;  Lu-Lu Shi;  Zhong-Qiang Bi;  Jing Cao;  John R. Speakman
收藏  |  浏览/下载:25/0  |  提交时间:2020/09/22
Petrogenesis of Late Triassic high-Mg diorites and associated granitoids with implications for Paleo-Tethys evolution in the northeast Tibetan Plateau 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 955-976
作者:  Tan, Jun;  Wei, Jun-Hao;  Zhao, Shao-Qing;  Li, Yan-Jun;  Liu, Yan;  Liu, Xiao-Yang;  Zhang, Fei;  Gan, Jin-Rong;  Wang, Zhi-Hua
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/02
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:55/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载:40/0  |  提交时间:2019/11/27
Foliar morphology and spatial distribution in five-year-old plantations of Betula alnoides 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 432: 514-521
作者:  Wang, Chun-sheng;  Guo, Jun-jie;  Hein, Sebastian;  Wang, Huan;  Zhao, Zhi-gang;  Zeng, Jie
收藏  |  浏览/下载:30/0  |  提交时间:2019/04/09
Betula alnoides  Crown structure  Leaf morphology traits  Leaf vertical distribution  Planting density  Specific leaf area  
"Perfect" designer chromosome V and behavior of a ring derivative 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Xie, Ze-Xiong;  Li, Bing-Zhi;  Mitchell, Leslie A.;  Wu, Yi;  Qi, Xin;  Jin, Zhu;  Jia, Bin;  Wang, Xia;  Zeng, Bo-Xuan;  Liu, Hui-Min;  Wu, Xiao-Le;  Feng, Qi;  Zhang, Wen-Zheng;  Liu, Wei;  Ding, Ming-Zhu;  Li, Xia;  Zhao, Guang-Rong;  Qiao, Jian-Jun;  Cheng, Jing-Sheng;  Zhao, Meng;  Kuang, Zheng;  Wang, Xuya;  Martin, J. Andrew;  Stracquadanio, Giovanni;  Yang, Kun;  Bai, Xue;  Zhao, Juan;  Hu, Meng-Long;  Lin, Qiu-Hui;  Zhang, Wen-Qian;  Shen, Ming-Hua;  Chen, Si;  etc
收藏  |  浏览/下载:33/0  |  提交时间:2019/11/27
热中性区漂移对黑线仓鼠最大持续能量收支限制的影响及生理机制研究 项目
项目编号:31670417; 经费:630000(CNY); 起止日期:2017 / dc_date_end
项目负责人:  赵志军
收藏  |  浏览/下载:28/0  |  提交时间:2019/04/11
21世纪地球科学研究的十大科学问题 快报文章
地球科学快报,2008年第8期
作者:  郑军卫;  张志强;  赵纪东
收藏  |  浏览/下载:29/0  |  提交时间:2020/05/19