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Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment 期刊论文
Science, 2021
作者:  Cleber A. Trujillo;  Edward S. Rice;  Nathan K. Schaefer;  Isaac A. Chaim;  Emily C. Wheeler;  Assael A. Madrigal;  Justin Buchanan;  Sebastian Preissl;  Allen Wang;  Priscilla D. Negraes;  Ryan A. Szeto;  Roberto H. Herai;  Alik Huseynov;  Mariana S. A. Ferraz;  Fernando S. Borges;  Alexandre H. Kihara;  Ashley Byrne;  Maximillian Marin;  Christopher Vollmers;  Angela N. Brooks;  Jonathan D. Lautz;  Katerina Semendeferi;  Beth Shapiro;  Gene W. Yeo;  Stephen E. P. Smith;  Richard E. Green;  Alysson R. Muotri
收藏  |  浏览/下载:12/0  |  提交时间:2021/02/17
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning 期刊论文
Environmental Health Perspectives, 2021
作者:  Skylar W. Marvel;  John S. House;  Matthew Wheeler;  Kuncheng Song;  Yi-Hui Zhou;  Fred A. Wright;  Weihsueh A. Chiu;  Ivan Rusyn;  Alison Motsinger-Reif;  David M. Reif
收藏  |  浏览/下载:6/0  |  提交时间:2021/01/15
Mapping carbon accumulation potential from global natural forest regrowth 期刊论文
Nature, 2020
作者:  Susan C. Cook-Patton;  Sara M. Leavitt;  David Gibbs;  Nancy L. Harris;  Kristine Lister;  Kristina J. Anderson-Teixeira;  Russell D. Briggs;  Robin L. Chazdon;  Thomas W. Crowther;  Peter W. Ellis;  Heather P. Griscom;  Valentine Herrmann;  Karen D. Holl;  Richard A. Houghton;  Cecilia Larrosa;  Guy Lomax;  Richard Lucas;  Palle Madsen;  Yadvinder Malhi;  Alain Paquette;  John D. Parker;  Keryn Paul;  Devin Routh;  Stephen Roxburgh;  Sassan Saatchi;  Johan van den Hoogen;  Wayne S. Walker;  Charlotte E. Wheeler;  Stephen A. Wood;  Liang Xu;  Bronson W. Griscom
收藏  |  浏览/下载:11/0  |  提交时间:2020/09/30
Active restoration accelerates the carbon recovery of human-modified tropical forests 期刊论文
Science, 2020
作者:  Christopher D. Philipson;  Mark E. J. Cutler;  Philip G. Brodrick;  Gregory P. Asner;  Doreen S. Boyd;  Pedro Moura Costa;  Joel Fiddes;  Giles M. Foody;  Geertje M. F. van der Heijden;  Alicia Ledo;  Philippa R. Lincoln;  James A. Margrove;  Roberta E. Martin;  Sol Milne;  Michelle A. Pinard;  Glen Reynolds;  Martijn Snoep;  Hamzah Tangki;  Yap Sau Wai;  Charlotte E. Wheeler;  David F. R. P. Burslem
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
Ice front blocking of ocean heat transport to an Antarctic ice shelf 期刊论文
NATURE, 2020, 578 (7796) : 568-+
作者:  Alexandrov, Ludmil B.;  Kim, Jaegil;  Haradhvala, Nicholas J.;  Huang, Mi Ni;  Ng, Alvin Wei Tian;  Wu, Yang;  Boot, Arnoud;  Covington, Kyle R.;  Gordenin, Dmitry A.;  Bergstrom, Erik N.;  Islam, S. M. Ashiqul;  Lopez-Bigas, Nuria;  Klimczak, Leszek J.;  McPherson, John R.;  Morganella, Sandro;  Sabarinathan, Radhakrishnan;  Wheeler, David A.;  Mustonen, Ville;  Getz, Gad;  Rozen, Steven G.;  Stratton, Michael R.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13

The front of the Getz Ice Shelf in West Antarctica creates an abrupt topographic step that deflects ocean currents, suppressing 70% of the heat delivery to the ice sheet.


Mass loss from the Antarctic Ice Sheet to the ocean has increased in recent decades, largely because the thinning of its floating ice shelves has allowed the outflow of grounded ice to accelerate(1,2). Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), motivating a recent focus on the processes that control ocean heat transport onto and across the seabed of the Antarctic continental shelf towards the ice(4-6). However, the shoreward heat flux typically far exceeds that required to match observed melt rates(2,7,8), suggesting that other critical controls exist. Here we show that the depth-independent (barotropic) component of the heat flow towards an ice shelf is blocked by the marked step shape of the ice front, and that only the depth-varying (baroclinic) component, which is typically much smaller, can enter the sub-ice cavity. Our results arise from direct observations of the Getz Ice Shelf system and laboratory experiments on a rotating platform. A similar blocking of the barotropic component may occur in other areas with comparable ice-bathymetry configurations, which may explain why changes in the density structure of the water column have been found to be a better indicator of basal melt rate variability than the heat transported onto the continental shelf(9). Representing the step topography of the ice front accurately in models is thus important for simulating ocean heat fluxes and induced melt rates.


  
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Convergent regulatory evolution and loss of flight in paleognathous birds 期刊论文
SCIENCE, 2019, 364 (6435) : 74-+
作者:  Sackton, Timothy B.;  Grayson, Phil;  Cloutier, Alison;  Hu, Zhirui;  Liu, Jun S.;  Wheeler, Nicole E.;  Gardner, Paul P.;  Clarke, Julia A.;  Baker, Allan J.;  Clamp, Michele;  Edwards, Scott V.
收藏  |  浏览/下载:90/0  |  提交时间:2019/11/27
The paradox of irrigation efficiency 期刊论文
SCIENCE, 2018, 361 (6404) : 748-750
作者:  Grafton, R. Q.;  Williams, J.;  Perry, C. J.;  Molle, F.;  Ringler, C.;  Steduto, P.;  Udall, B.;  Wheeler, S. A.;  Wang, Y.;  Garrick, D.;  Allen, R. G.
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
Using smartphone technology to reduce health impacts from atmospheric environmental hazards 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (4)
作者:  Johnston, F. H.;  Wheeler, A. J.;  Williamson, G. J.;  Campbell, S. L.;  Jones, P. J.;  Koolhof, I. S.;  Lucani, C.;  Cooling, N. B.;  Bowman, D. M. J. S.
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
air polluton  pollen  smartphone app  health  symptom surveillance  
Anatomy of STEM teaching in North American universities Lecture is prominent, but practices vary 期刊论文
SCIENCE, 2018, 359 (6383) : 1468-1470
作者:  Stains, M.;  Harshman, J.;  Barker, M. K.;  Chasteen, S. V.;  Cole, R.;  DeChenne-Peters, S. E.;  Eagan, M. K., Jr.;  Esson, J. M.;  Knight, J. K.;  Laski, F. A.;  Levis-Fitzgerald, M.;  Lee, C. J.;  Lo, S. M.;  McDonnell, L. M.;  Mckay, T. A.;  Michelotti, N.;  Musgrove, A.;  Palmer, M. S.;  Plank, K. M.;  Rodela, T. M.;  Sanders, E. R.;  Schimpf, N. G.;  Schulte, P. M.;  Smith, M. K.;  Stetzer, M.;  Van Valkenburgh, B.;  Vinson, E.;  Weir, L. K.;  Wendel, P. J.;  Wheeler, L. B.;  Young, A. M.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27