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Estuarine plastisphere as an overlooked source of N2O production 期刊论文
Nature Communications, 2022
作者:  Su, Xiaoxuan;  Yang, Leyang;  Yang, Kai;  Tang, Yijia;  Wen, Teng;  Wang, Yingmu;  Rillig, Matthias C.;  Rohe, Lena;  Pan, Junliang;  Li, Hu;  Zhu, Yong-guan
收藏  |  浏览/下载:19/0  |  提交时间:2022/07/08
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons 期刊论文
Science, 2021
作者:  Dylan A. Reid;  Patrick J. Reed;  Johannes C. M. Schlachetzki;  Ioana I. Nitulescu;  Grace Chou;  Enoch C. Tsui;  Jeffrey R. Jones;  Sahaana Chandran;  Ake T. Lu;  Claire A. McClain;  Jean H. Ooi;  Tzu-Wen Wang;  Addison J. Lana;  Sara B. Linker;  Anthony S. Ricciardulli;  Shong Lau;  Simon T. Schafer;  Steve Horvath;  Jesse R. Dixon;  Nasun Hah;  Christopher K. Glass;  Fred H. Gage
收藏  |  浏览/下载:15/0  |  提交时间:2021/04/06
Partitioning net ecosystem exchange (NEE) of CO2 using Solar‐Induced chlorophyll Fluorescence (SIF) 期刊论文
Geophysical Research Letters, 2021
作者:  O. Kira;  C. Y‐;  Y. Chang;  L. Gu;  J. Wen;  Z. Hong;  Y. Sun
收藏  |  浏览/下载:7/0  |  提交时间:2021/02/17
New Guinea has the world鈥檚 richest island flora 期刊论文
Nature, 2020
作者:  Rodrigo Cá;  mara-Leret;  David G. Frodin;  Frits Adema;  Christiane Anderson;  Marc S. Appelhans;  George Argent;  Susana Arias Guerrero;  Peter Ashton;  William J. Baker;  Anders S. Barfod;  David Barrington;  Renata Borosova;  Gemma L. C. Bramley;  Marie Briggs;  Sven Buerki;  Daniel Cahen;  Martin W. Callmander;  Martin Cheek;  Cheng-Wei Chen;  Barry J. Conn;  Mark J. E. Coode;  Iain Darbyshire;  Sally Dawson;  John Dransfield;  Clare Drinkell;  Brigitta Duyfjes;  Atsushi Ebihara;  Zacky Ezedin;  Long-Fei Fu;  Osia Gideon;  Deden Girmansyah;  Rafaë;  l Govaerts;  Helen Fortune-Hopkins;  Gustavo Hassemer;  Alistair Hay;  Charlie D. Heatubun;  D. J. Nicholas Hind;  Peter Hoch;  Peter Homot;  Peter Hovenkamp;  Mark Hughes;  Matthew Jebb;  Laura Jennings;  Tiberius Jimbo;  Michael Kessler;  Ruth Kiew;  Sandra Knapp;  Penniel Lamei;  Marcus Lehnert;  Gwilym P. Lewis;  Hans Peter Linder;  Stuart Lindsay;  Yee Wen Low;  Eve Lucas;  Jeffrey P. Mancera;  Alexandre K. Monro;  Alison Moore;  David J. Middleton;  Hidetoshi Nagamasu;  Mark F. Newman;  Eimear Nic Lughadha;  Pablo H. A. Melo;  Daniel J. Ohlsen;  Caroline M. Pannell;  Barbara Parris;  Laura Pearce;  Darin S. Penneys;  Leon R. Perrie;  Peter Petoe;  Axel Dalberg Poulsen;  Ghillean T. Prance;  J. Peter Quakenbush;  Niels Raes;  Michele Rodda;  Zachary S. Rogers;  André;  Schuiteman;  Pedro Schwartsburd;  Robert W. Scotland;  Mark P. Simmons;  David A. Simpson;  Peter Stevens;  Michael Sundue;  Weston Testo;  Anna Trias-Blasi;  Ian Turner;  Timothy Utteridge;  Lesley Walsingham;  Bruce L. Webber;  Ran Wei;  George D. Weiblen;  Maximilian Weigend;  Peter Weston;  Willem de Wilde;  Peter Wilkie;  Christine M. Wilmot-Dear;  Hannah P. Wilson;  John R. I. Wood;  Li-Bing Zhang;  Peter C. van Welzen
收藏  |  浏览/下载:32/0  |  提交时间:2020/08/18
Global status and conservation potential of reef sharks 期刊论文
Nature, 2020
作者:  M. Aaron MacNeil;  Demian D. Chapman;  Michelle Heupel;  Colin A. Simpfendorfer;  Michael Heithaus;  Mark Meekan;  Euan Harvey;  Jordan Goetze;  Jeremy Kiszka;  Mark E. Bond;  Leanne M. Currey-Randall;  Conrad W. Speed;  C. Samantha Sherman;  Matthew J. Rees;  Vinay Udyawer;  Kathryn I. Flowers;  Gina Clementi;  Jasmine Valentin-Albanese;  Taylor Gorham;  M. Shiham Adam;  Khadeeja Ali;  Fabiá;  n Pina-Amargó;  s;  Jorge A. Angulo-Valdé;  s;  Jacob Asher;  Laura Garcí;  a Barcia;  Océ;  ane Beaufort;  Cecilie Benjamin;  Anthony T. F. Bernard;  Michael L. Berumen;  Stacy Bierwagen;  Erika Bonnema;  Rosalind M. K. Bown;  Darcey Bradley;  Edd Brooks;  J. Jed Brown;  Dayne Buddo;  Patrick Burke;  Camila Cá;  ceres;  Diego Cardeñ;  osa;  Jeffrey C. Carrier;  Jennifer E. Caselle;  Venkatesh Charloo;  Thomas Claverie;  Eric Clua;  Jesse E. M. Cochran;  Neil Cook;  Jessica Cramp;  Brooke D’;  Alberto;  Martin de Graaf;  Mareike Dornhege;  Andy Estep;  Lanya Fanovich;  Naomi F. Farabough;  Daniel Fernando;  Anna L. Flam;  Camilla Floros;  Virginia Fourqurean;  Ricardo Garla;  Kirk Gastrich;  Lachlan George;  Rory Graham;  Tristan Guttridge;  Royale S. Hardenstine;  Stephen Heck;  Aaron C. Henderson;  Heidi Hertler;  Robert Hueter;  Mohini Johnson;  Stacy Jupiter;  Devanshi Kasana;  Steven T. Kessel;  Benedict Kiilu;  Taratu Kirata;  Baraka Kuguru;  Fabian Kyne;  Tim Langlois;  Elodie J. I. Lé;  ;  e;  Steve Lindfield;  Andrea Luna-Acosta;  Jade Maggs;  B. Mabel Manjaji-Matsumoto;  Andrea Marshall;  Philip Matich;  Erin McCombs;  Dianne McLean;  Llewelyn Meggs;  Stephen Moore;  Sushmita Mukherji;  Ryan Murray;  Muslimin Kaimuddin;  Stephen J. Newman;  Josep Nogué;  s;  Clay Obota;  Owen O’;  Shea;  Kennedy Osuka;  Yannis P. Papastamatiou;  Nishan Perera;  Bradley Peterson;  Alessandro Ponzo;  Andhika Prasetyo;  L. M. Sjamsul Quamar;  Jessica Quinlan;  Alexei Ruiz-Abierno;  Enric Sala;  Melita Samoilys;  Michelle Schä;  rer-Umpierre;  Audrey Schlaff;  Nikola Simpson;  Adam N. H. Smith;  Lauren Sparks;  Akshay Tanna;  Rubé;  n Torres;  Michael J. Travers;  Maurits van Zinnicq Bergmann;  Laurent Vigliola;  Juney Ward;  Alexandra M. Watts;  Colin Wen;  Elizabeth Whitman;  Aaron J. Wirsing;  Aljoscha Wothke;  Esteban Zarza-Gonzâ;  lez;  Joshua E. Cinner
收藏  |  浏览/下载:17/0  |  提交时间:2020/08/09
Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses 期刊论文
Science, 2020
作者:  Nicholas C. Wu;  Andrew J. Thompson;  Juhye M. Lee;  Wen Su;  Britni M. Arlian;  Jia Xie;  Richard A. Lerner;  Hui-Ling Yen;  Jesse D. Bloom;  Ian A. Wilson
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/22
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).


  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.