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The Role of Precautionary and Speculative Demand in the Global Market for Crude Oil 科技报告
来源:Environment for Development Initiative. 出版年: 2022
作者:  Jamie L. Cross;  Bao H. Nguyen;  Trung Duc Tran
收藏  |  浏览/下载:7/0  |  提交时间:2022/06/24
A flood risk framework capturing the seasonality of and dependence between rainfall and sea levels – an application to Ho Chi Minh City, Vietnam 期刊论文
Water Resources Research, 2022
作者:  A. Couasnon;  P. Scussolini;  T. V. T. Tran;  D. Eilander;  S. Muis;  H. Wang;  J. Keesom;  J. Dullaart;  Y. Xuan;  H. Q. Nguyen;  H. C. Winsemius;  P. J. Ward
收藏  |  浏览/下载:14/0  |  提交时间:2022/01/29
The potential for REDD plus to reduce forest degradation in Vietnam 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Ngo, D. T.;  Le, A., V;  Le, H. T.;  Stas, S. M.;  Le, T. C.;  Tran, H. D.;  Pham, T.;  Le, T. T.;  Spracklen, B. D.;  Langan, C.;  Cuthbert, R.;  Buermann, W.;  Phillips, O. L.;  Jew, E. K. K.;  Spracklen, D., V
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/18
forest degradation  REDD plus  livelihoods  
A metabolic pathway for bile acid dehydroxylation by the gut microbiome 期刊论文
NATURE, 2020
作者:  Zhong, Miao;  Tran, Kevin;  Min, Yimeng;  Wang, Chuanhao;  Wang, Ziyun;  Dinh, Cao-Thang;  De Luna, Phil;  Yu, Zongqian;  Rasouli, Armin Sedighian;  Brodersen, Peter;  Sun, Song;  Voznyy, Oleksandr;  Tan, Chih-Shan;  Askerka, Mikhail;  Che, Fanglin;  Liu, Min;  Seifitokaldani, Ali;  Pang, Yuanjie;  Lo, Shen-Chuan;  Ip, Alexander;  Ulissi, Zachary;  Sargent, Edward H.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

The biosynthetic pathway that produces the secondary bile acids DCA and LCA in human gut microbes has been fully characterized, engineered into another bacterial host, and used to confer DCA production in germ-free mice-an important proof-of-principle for the engineering of gut microbial pathways.


The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 mu M and are known to block the growth ofClostridium difficile(1), promote hepatocellular carcinoma(2)and modulate host metabolism via the G-protein-coupled receptor TGR5 (ref.(3)). More broadly, DCA, LCA and their derivatives are major components of the recirculating pool of bile acids(4)  the size and composition of this pool are a target of therapies for primary biliary cholangitis and nonalcoholic steatohepatitis. Nonetheless, despite the clear impact of DCA and LCA on host physiology, an incomplete knowledge of their biosynthetic genes and a lack of genetic tools to enable modification of their native microbial producers limit our ability to modulate secondary bile acid levels in the host. Here we complete the pathway to DCA and LCA by assigning and characterizing enzymes for each of the steps in its reductive arm, revealing a strategy in which the A-B rings of the steroid core are transiently converted into an electron acceptor for two reductive steps carried out by Fe-S flavoenzymes. Using anaerobic in vitro reconstitution, we establish that a set of six enzymes is necessary and sufficient for the eight-step conversion of cholic acid to DCA. We then engineer the pathway intoClostridium sporogenes, conferring production of DCA and LCA on a nonproducing commensal and demonstrating that a microbiome-derived pathway can be expressed and controlled heterologously. These data establish a complete pathway to two central components of the bile acid pool.


  
Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (1) : 539-559
作者:  Chan, Lam Kam;  Nguyen, Khanh Q.;  Karim, Noreen;  Yang, Yatian;  Rice, Robert H.;  He, Guochun;  Denison, Michael S.;  Nguyen, Tran B.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
Depth- and Time-Resolved Distributions of Snowmelt-Driven Hillslope Subsurface Flow and Transport and Their Contributions to Surface Waters 期刊论文
WATER RESOURCES RESEARCH, 2019
作者:  Tokunaga, Tetsu K.;  Wan, Jiamin;  Williams, Kenneth H.;  Brown, Wendy;  Henderson, Amanda;  Kim, Yongman;  Tran, Anh Phuong;  Conrad, Mark E.;  Bill, Markus;  Carroll, Rosemary W. H.;  Dong, Wenming;  Xu, Zexuan;  Lavy, Adi;  Gilbert, Ben;  Romero, Sergio;  Christensen, John N.;  Faybishenko, Boris;  Arora, Bhavna;  Siirila-Woodburn, Erica R.;  Versteeg, Roelof;  Raberg, Jonathan H.;  Peterson, John E.;  Hubbard, Susan S.
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/16
recharge  hillslope  transmissivity  concentration-discharge  groundwater  snowmelt  
Low-volatility compounds contribute significantly to isoprene secondary organic aerosol (SOA) under high-NOx conditions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (11) : 7255-7278
作者:  Schwantes, Rebecca H.;  Charan, Sophia M.;  Bates, Kelvin H.;  Huang, Yuanlong;  Nguyen, Tran B.;  Mai, Huajun;  Kong, Weimeng;  Flagan, Richard C.;  Seinfeld, John H.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
Measurement and Modeling of Air-Broadened Methane Absorption in the MERLIN Spectral Region at Low Temperatures 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (6) : 3556-3564
作者:  Delahaye, T.;  Ghysels, M.;  Hodges, J. T.;  Sung, K.;  Armante, R.;  Tran, H.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
MERLIN  atmospheric methane  absorption cross section  line shape  
Indirect Influence of Humidity on Atmospheric Spectra Near 4 mu m 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (22) : 12593-12601
作者:  Hartmann, J. -M.;  Armante, R.;  Toon, G. C.;  Scott, N.;  Tran, H.;  Crevoisier, C.;  Chedin, A.;  Capelle, V.
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
atmospheric spectra  4 mu m region  influence of humidity  N-2 collision-induced absorption  CO2 line wings  surface temperature retrievals