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CATMoS: Collaborative Acute Toxicity Modeling Suite 期刊论文
Environmental Health Perspectives, 2021
作者:  Kamel Mansouri;  Agnes L. Karmaus;  Jeremy Fitzpatrick;  Grace Patlewicz;  Prachi Pradeep;  Domenico Alberga;  Nathalie Alepee;  Timothy E.H. Allen;  Dave Allen;  Vinicius M. Alves;  Carolina H. Andrade;  Tyler R. Auernhammer;  Davide Ballabio;  Shannon Bell;  Emilio Benfenati;  Sudin Bhattacharya;  Joyce V. Bastos;  Stephen Boyd;  J.B. Brown;  Stephen J. Capuzzi;  Yaroslav Chushak;  Heather Ciallella;  Alex M. Clark;  Viviana Consonni;  Pankaj R. Daga;  Sean Ekins;  Sherif Farag;  Maxim Fedorov;  Denis Fourches;  Domenico Gadaleta;  Feng Gao;  Jeffery M. Gearhart;  Garett Goh;  Jonathan M. Goodman;  Francesca Grisoni;  Christopher M. Grulke;  Thomas Hartung;  Matthew Hirn;  Pavel Karpov;  Alexandru Korotcov;  Giovanna J. Lavado;  Michael Lawless;  Xinhao Li;  Thomas Luechtefeld;  Filippo Lunghini;  Giuseppe F. Mangiatordi;  Gilles Marcou;  Dan Marsh;  Todd Martin;  Andrea Mauri;  Eugene N. Muratov;  Glenn J. Myatt;  Dac-Trung Nguyen;  Orazio Nicolotti;  Reine Note;  Paritosh Pande;  Amanda K. Parks;  Tyler Peryea;  Ahsan H. Polash;  Robert Rallo;  Alessandra Roncaglioni;  Craig Rowlands;  Patricia Ruiz;  Daniel P. Russo;  Ahmed Sayed;  Risa Sayre;  Timothy Sheils;  Charles Siegel;  Arthur C. Silva;  Anton Simeonov;  Sergey Sosnin;  Noel Southall;  Judy Strickland;  Yun Tang;  Brian Teppen;  Igor V. Tetko;  Dennis Thomas;  Valery Tkachenko;  Roberto Todeschini;  Cosimo Toma;  Ignacio Tripodi;  Daniela Trisciuzzi;  Alexander Tropsha;  Alexandre Varnek;  Kristijan Vukovic;  Zhongyu Wang;  Liguo Wang;  Katrina M. Waters;  Andrew J. Wedlake;  Sanjeeva J. Wijeyesakere;  Dan Wilson;  Zijun Xiao;  Hongbin Yang;  Gergely Zahoranszky-Kohalmi;  Alexey V. Zakharov;  Fagen F. Zhang;  Zhen Zhang;  Tongan Zhao;  Hao Zhu;  Kimberley M. Zorn;  Warren Casey;  Nicole C. Kleinstreuer
收藏  |  浏览/下载：20/0  |  提交时间：2021/05/07
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.


  
Quantitative mass imaging of single biological macromolecules 期刊论文
SCIENCE, 2018, 360 (6387) : 423-+
作者:  Young, Gavin;  Hundt, Nikolas;  Cole, Daniel;  Fineberg, Adam;  Andrecka, Joanna;  Tyler, Andrew;  Olerinyova, Anna;  Ansari, Ayla;  Marklund, Erik G.;  Collier, Miranda P.;  Chandler, Shane A.;  Tkachenko, Olga;  Allen, Joel;  Crispin, Max;  Billington, Neil;  Takagi, Yasuharu;  Sellers, James R.;  Eichmann, Cedric;  Selenko, Philipp;  Frey, Lukas;  Riek, Roland;  Galpin, Martin R.;  Struwe, Weston B.;  Benesch, Justin L. P.;  Kukura, Philipp
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27