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A new wrinkle on liquid sheets: Turning the mechanism of viscous bubble collapse upside down 期刊论文
Science, 2020
作者:  Alexandros T. Oratis;  John W. M. Bush;  Howard A. Stone;  James C. Bird
收藏  |  浏览/下载:7/0  |  提交时间:2020/08/18
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
Quantifying contributions of chlorofluorocarbon banks to emissions and impacts on the ozone layer and climate 期刊论文
Nature, 2020
作者:  Megan Lickley;  Susan Solomon;  Sarah Fletcher;  Guus J. M. Velders;  John Daniel;  Matthew Rigby;  Stephen A. Montzka;  Lambert J. M. Kuijpers;  Kane Stone
收藏  |  浏览/下载:6/0  |  提交时间:2020/05/13
Ambient air quality in the Kathmandu Valley, Nepal, during the pre-monsoon: concentrations and sources of particulate matter and trace gases 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2927-2951
作者:  Islam, Md Robiul;  Jayarathne, Thilina;  Simpson, Isobel J.;  Werden, Benjamin;  Maben, John;  Gilbert, Ashley;  Praveen, Puppala S.;  Adhikari, Sagar;  Panday, Arnico K.;  Rupakheti, Maheswar;  Blake, Donald R.;  Yokelson, Robert J.;  DeCarlo, Peter F.;  Keene, William C.;  Stone, Elizabeth A.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
Large-scale tropospheric transport in the Chemistry-Climate Model Initiative (CCMI) simulations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (10) : 7217-7235
作者:  Orbe, Clara;  Yang, Huang;  Waugh, Darryn W.;  Zeng, Guang;  Morgenstern, Olaf;  Kinnison, Douglas E.;  Lamarque, Jean-Francois;  Tilmes, Simone;  Plummer, David A.;  Scinocca, John F.;  Josse, Beatrice;  Marecal, Virginie;  Joeckel, Patrick;  Oman, Luke D.;  Strahan, Susan E.;  Deushi, Makoto;  Tanaka, Taichu Y.;  Yoshida, Kohei;  Akiyoshi, Hideharu;  Yamashita, Yousuke;  Stenke, Andreas;  Revell, Laura;  Sukhodolov, Timofei;  Rozanov, Eugene;  Pitari, Giovanni;  Visioni, Daniele;  Stone, Kane A.;  Schofield, Robyn;  Banerjee, Antara
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
Quantifying the effect of mixing on the mean age of air in CCMVal-2 and CCMI-1 models 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (9) : 6699-6720
作者:  Dietmueller, Simone;  Eichinger, Roland;  Garny, Hella;  Birner, Thomas;  Boenisch, Harald;  Pitari, Giovanni;  Mancini, Eva;  Visioni, Daniele;  Stenke, Andrea;  Revell, Laura;  Rozanov, Eugene;  Plummer, David A.;  Scinocca, John;  Joeckel, Patrick;  Oman, Luke;  Deushi, Makoto;  Kiyotaka, Shibata;  Kinnison, Douglas E.;  Garcia, Rolando;  Morgenstern, Olaf;  Zeng, Guang;  Stone, Kane Adam;  Schofield, Robyn
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Ozone sensitivity to varying greenhouse gases and ozone-depleting substances in CCMI-1 simulations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (2) : 1091-1114
作者:  Morgenstern, Olaf;  Stone, Kane A.;  Schofield, Robyn;  Akiyoshi, Hideharu;  Yamashita, Yousuke;  Kinnison, Douglas E.;  Garcia, Rolando R.;  Sudo, Kengo;  Plummer, David A.;  Scinocca, John;  Oman, Luke D.;  Manyin, Michael E.;  Zeng, Guang;  Rozanov, Eugene;  Stenke, Andrea;  Revell, Laura E.;  Pitari, Giovanni;  Mancini, Eva;  Di Genova, Glauco;  Visioni, Daniele;  Dhomse, Sandip S.;  Chipperfield, Martyn P.
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
Coherent band excitations in CePd3: A comparison of neutron scattering and ab initio theory 期刊论文
SCIENCE, 2018, 359 (6372) : 186-190
作者:  Goremychkin, Eugene A.;  Park, Hyowon;  Osborn, Raymond;  Rosenkranz, Stephan;  Castellan, John-Paul;  Fanelli, Victor R.;  Christianson, Andrew D.;  Stone, Matthew B.;  Bauer, Eric D.;  McClellan, Kenneth J.;  Byler, Darrin D.;  Lawrence, Jon M.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Rapid early-Holocene deglaciation in the Ross Sea, Antarctica 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (15)
作者:  Spector, Perry;  Stone, John;  Cowdery, Seth G.;  Hall, Brenda;  Conway, Howard;  Bromley, Gordon
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution 期刊论文
NATURE, 2017, 545 (7655) : 446-+
作者:  Abbosh, Christopher;  Birkbak, Nicolai J.;  Wilson, Gareth A.;  Jamal-Hanjani, Mariam;  Constantin, Tudor;  Salari, Raheleh;  Le Quesne, John;  Moore, David A.;  Veeriah, Selvaraju;  Rosenthal, Rachel;  Marafioti, Teresa;  Kirkizlar, Eser;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Ward, Sophia;  Martinson, Luke;  Riley, Joan;  Fraioli, Francesco;  Al Bakir, Maise;  Gronroos, Eva;  Zambrana, Francisco;  Endozo, Raymondo;  Bi, Wenya Linda;  Fennessy, Fiona M.;  Sponer, Nicole;  Johnson, Diana;  Laycock, Joanne;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Rowan, Andrew;  Chambers, Tim;  Matthews, Nik;  Turajlic, Samra;  Hiley, Crispin;  Lee, Siow Ming;  Forster, Martin D.;  Ahmad, Tanya;  Falzon, Mary;  Borg, Elaine;  Lawrence, David;  Hayward, Martin;  Kolvekar, Shyam;  Panagiotopoulos, Nikolaos;  Janes, Sam M.;  Thakrar, Ricky;  Ahmed, Asia;  Blackhall, Fiona;  Summers, Yvonne;  Hafez, Dina;  Naik, Ashwini;  Ganguly, Apratim;  Kareht, Stephanie;  Shah, Rajesh;  Joseph, Leena;  Quinn, Anne Marie;  Crosbie, Phil A.;  Naidu, Babu;  Middleton, Gary;  Langman, Gerald;  Trotter, Simon;  Nicolson, Marianne;  Remmen, Hardy;  Kerr, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Fennell, Dean A.;  Nakas, Apostolos;  Rathinam, Sridhar;  Anand, Girija;  Khan, Sajid;  Russell, Peter;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Lester, Jason F.;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Adams, Haydn;  Davies, Helen;  Oukrif, Dahmane;  Akarca, Ayse U.;  Hartley, John A.;  Lowe, Helen L.;  Lock, Sara;  Iles, Natasha;  Bell, Harriet;  Ngai, Yenting;  Elgar, Greg;  Szallasi, Zoltan;  Schwarz, Roland F.;  Herrero, Javier;  Stewart, Aengus;  Quezada, Sergio A.;  Peggs, Karl S.;  Van Loo, Peter;  Dive, Caroline;  Lin, C. Jimmy;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Hackshaw, Allan;  Shaw, Jacqui A.;  Zimmermann, Bernhard G.;  Swanton, Charles;  Jamal-Hanjani, Mariam;  Abbosh, Christopher;  Veeriah, Selvaraju;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Johnson, Diana;  Laycock, Joanne;  Bosshard-Carter, Leticia;  Goh, Gerald;  Rosenthal, Rachel;  Gorman, Pat;  Murugaesu, Nirupa;  Hynds, Robert E.;  Wilson, Gareth A.;  Birkbak, Nicolai J.;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Horswell, Stuart;  Al Bakir, Maise;  Gronroos, Eva;  Mitter, Richard;  Escudero, Mickael;  Stewart, Aengus;  Van Loo, Peter;  Rowan, Andrew;  Xu, Hang;  Turajlic, Samra;  Hiley, Crispin;  Goldman, Jacki;  Stone, Richard Kevin;  Denner, Tamara;  Matthews, Nik;  Elgar, Greg;  Ward, Sophia;  Biggs, Jennifer;  Costa, Marta;  Begum, Sharmin;  Phillimore, Ben;  Chambers, Tim;  Nye, Emma;  Graca, Sofia;  Joshi, Kroopa;  Furness, Andrew;  Ben Aissa, Assma;  Wong, Yien Ning Sophia;  Georgiou, Andy;  Quezada, Sergio A.;  Peggs, Karl S.;  Hartley, John A.;  Lowe, Helen L.;  Herrero, Javier;  Lawrence, David;  Hayward, Martin;  Panagiotopoulos, Nikolaos;  Kolvekar, Shyam;  Falzon, Mary;  Borg, Elaine;  Marafioti, Teresa;  Simeon, Celia;  Hector, Gemma;  Smith, Amy;  Aranda, Marie;  Novelli, Marco;  Oukrif, Dahmane;  Akarca, Ayse U.;  Janes, Sam M.;  Thakrar, Ricky;  Forster, Martin D.;  Ahmad, Tanya;  Lee, Siow Ming;  Papadatos-Pastos, Dionysis;  Carnell, Dawn;  Mendes, Ruheena;  George, Jeremy;  Navani, Neal;  Ahmed, Asia;  Taylor, Magali;  Choudhary, Junaid;  Summers, Yvonne;  Califano, Raffaele;  Taylor, Paul;  Shah, Rajesh;  Krysiak, Piotr;  Rammohan, Kendadai;  Fontaine, Eustace;  Booton, Richard;  Evison, Matthew;  Crosbie, Phil A.;  Moss, Stuart;  Idries, Faiza;  Joseph, Leena;  Bishop, Paul;  Chaturvedi, Anshuman;  Quinn, Anne Marie;  Doran, Helen;  Leek, Angela;  Harrison, Phil;  Moore, Katrina;  Waddington, Rachael;  Novasio, Juliette;  Blackhall, Fiona;  Rogan, Jane;  Smith, Elaine;  Dive, Caroline;  Tugwood, Jonathan;  Brady, Ged;  Rothwell, Dominic G.;  Chemi, Francesca;  Pierce, Jackie;  Gulati, Sakshi;  Naidu, Babu;  Langman, Gerald;  Trotter, Simon;  Bellamy, Mary;  Bancroft, Hollie;  Kerr, Amy;  Kadiri, Salma;  Webb, Joanne;  Middleton, Gary;  Djearaman, Madava;  Fennell, Dean A.;  Shaw, Jacqui A.;  Le Quesne, John;  Moore, David A.;  Thomas, Anne;  Walter, Harriet;  Riley, Joan;  Martinson, Luke;  Nakas, Apostolos;  Rathinam, Sridhar;  Monteiro, William;  Marshall, Hilary;  Nelson, Louise;  Bennett, Jonathan;  Primrose, Lindsay;  Anand, Girija;  Khan, Sajid;  Amadi, Anita;  Nicolson, Marianne;  Kerr, Keith;  Palmer, Shirley;  Remmen, Hardy;  Miller, Joy;  Buchan, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Lester, Jason F.;  Edwards, Alison;  Morgan, Fiona;  Adams, Haydn;  Davies, Helen;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Lock, Sara;  Verjee, Azmina;  MacKenzie, Mairead;  Wilcox, Maggie;  Bell, Harriet;  Iles, Natasha;  Hackshaw, Allan;  Ngai, Yenting;  Smith, Sean;  Gower, Nicole;  Ottensmeier, Christian;  Chee, Serena;  Johnson, Benjamin;  Alzetani, Aiman;  Shaw, Emily;  Lim, Eric;  De Sousa, Paulo;  Barbosa, Monica Tavares;  Bowman, Alex;  Jordan, Simon;  Rice, Alexandra;  Raubenheimer, Hilgardt;  Proli, Chiara;  Cufari, Maria Elena;  Ronquillo, John Carlo;  Kwayie, Angela;  Bhayani, Harshil;  Hamilton, Morag;  Bakar, Yusura;  Mensah, Natalie;  Ambrose, Lyn;  Devaraj, Anand;  Buderi, Silviu;  Finch, Jonathan;  Azcarate, Leire;  Chavan, Hema;  Green, Sophie;  Mashinga, Hillaria;  Nicholson, Andrew G.;  Lau, Kelvin;  Sheaff, Michael;  Schmid, Peter;  Conibear, John;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Russell, Peter;  Light, Teresa;  Horey, Tracey;  Danson, Sarah;  Bury, Jonathan;  Edwards, John;  Hill, Jennifer;  Matthews, Sue;  Kitsanta, Yota;  Suvarna, Kim;  Fisher, Patricia;  Keerio, Allah Dino;  Shackcloth, Michael;  Gosney, John;  Postmus, Pieter;  Feeney, Sarah;  Asante-Siaw, Julius;  Constantin, Tudor;  Salari, Raheleh;  Sponer, Nicole;  Naik, Ashwini;  Zimmermann, Bernhard G.;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Dentro, Stefan;  Dessimoz, Christophe
收藏  |  浏览/下载:27/0  |  提交时间:2019/04/09