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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载:14/0  |  提交时间:2021/04/06
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Effects of Temperature on Tidally Influenced Coastal Unconfined Aquifers 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (4)
作者:  Nguyen, Thuy T. M.;  Yu, Xiayang;  Pu, Li;  Xin, Pei;  Zhang, Chenming;  Barry, D. A.;  Li, Ling
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
aquifer  subterranean estuary  submarine groundwater discharge  saltwater intrusion  temperature  
CO2 mineralization and utilization by alkaline solid wastes for potential carbon reduction 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (5) : 399-405
作者:  Pan, Shu-Yuan;  Chen, Yi-Hung;  Fan, Liang-Shih;  Kim, Hyunook;  Gao, Xiang;  Ling, Tung-Chai;  Chiang, Pen-Chi;  Pei, Si-Lu;  Gu, Guowei
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
Fog Interception Maintains a Major Waterfall Landscape in Southwest China Revealed by Isotopic Signatures 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (3)
作者:  Zhan, Lucheng;  Chen, Jiansheng;  Zhang, Chenming;  Wang, Tao;  Xin, Pei;  Li, Ling
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/02
Combined Effect of Tides and Varying Inland Groundwater Input on Flow and Salinity Distribution in Unconfined Coastal Aquifers 期刊论文
WATER RESOURCES RESEARCH, 2019
作者:  Kuan, Woei Keong;  Xin, Pei;  Jin, Guangqiu;  Robinson, Clare E.;  Gibbes, Badin;  Li, Ling
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/16
submarine groundwater discharge  subterranean estuary  coastal water quality  saltwater intrusion  oceanic oscillations  
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Qiu, Fang;  Tang, Ruqi;  Zuo, Xianbo;  Shi, Xingjuan;  Wei, Yiran;  Zheng, Xiaodong;  Dai, Yaping;  Gong, Yuhua;  Wang, Lan;  Xu, Ping;  Zhu, Xiang;  Wu, Jian;  Han, Chongxu;  Gao, Yueqiu;  Zhang, Kui;  Jiang, Yuzhang;  Zhou, Jianbo;  Shao, Youlin;  Hu, Zhigang;  Tian, Ye;  Zhang, Haiyan;  Dai, Na;  Liu, Lei;  Wu, Xudong;  Zhao, Weifeng;  Zhang, Xiaomin;  Zang, Zhidong;  Nie, Jinshan;  Sun, Weihao;  Zhao, Yi;  Mao, Yuan;  Jiang, Po;  Ji, Hualiang;  Dong, Qing;  Li, Junming;  Li, Zhenzhong;  Bai, Xinli;  Li, Li;  Lin, Maosong;  Dong, Ming;  Li, Jinxin;  Zhu, Ping;  Wang, Chan;  Zhang, Yanqiu;  Jiang, Peng;  Wang, Yujue;  Jawed, Rohil;  Xu, Jing;  Zhang, Yu;  Wang, Qixia;  Yang, Yue;  Yang, Fan;  Lian, Min;  Jiang, Xiang;  Xiao, Xiao;  Li, Yanmei;  Fang, Jingyuan;  Qiu, Dekai;  Zhu, Zhen;  Qiu, Hong;  Zhang, Jianqiong;  Tian, Wenyan;  Chen, Sufang;  Jiang, Ling;  Ji, Bing;  Li, Ping;  Chen, Guochang;  Wu, Tianxue;  Sun, Yan;  Yu, Jianjiang;  Tang, Huijun;  He, Michun;  Xia, Min;  Pei, Hao;  Huang, Lihua;  Qing, Zhuye;  Wu, Jianfang;  Huang, Qinghai;  Han, Junhai;  Xie, Wei;  Sun, Zhongsheng;  Guo, Jian;  He, Gengsheng;  Gershwin, M. Eric;  Lian, Zhexiong;  Liu, Xiang;  Seldin, Michael F.;  Liu, Xiangdong;  Chen, Weichang;  Ma, Xiong
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Impacts of species richness on productivity in a large-scale subtropical forest experiment 期刊论文
SCIENCE, 2018, 362 (6410) : 80-+
作者:  Huang, Yuanyuan;  Chen, Yuxin;  Castro-Izaguirre, Nadia;  Baruffol, Martin;  Brezzi, Matteo;  Lang, Anne;  Li, Ying;  Haerdtle, Werner;  von Oheimb, Goddert;  Yang, Xuefei;  Liu, Xiaojuan;  Pei, Kequan;  Both, Sabine;  Yang, Bo;  Eichenberg, David;  Assmann, Thorsten;  Bauhus, Juergen;  Behrens, Thorsten;  Buscot, Francois;  Chen, Xiao-Yong;  Chesters, Douglas;  Ding, Bing-Yang;  Durka, Walter;  Erfmeier, Alexandra;  Fang, Jingyun;  Fischer, Markus;  Guo, Liang-Dong;  Guo, Dali;  Gutknecht, Jessica L. M.;  He, Jin-Sheng;  He, Chun-Ling;  Hector, Andy;  Hoenig, Lydia;  Hu, Ren-Yong;  Klein, Alexandra-Maria;  Kuehn, Peter;  Liang, Yu;  Li, Shan;  Michalski, Stefan;  Scherer-Lorenzen, Michael;  Schmidt, Karsten;  Scholten, Thomas;  Schuldt, Andreas;  Shi, Xuezheng;  Tan, Man-Zhi;  Tang, Zhiyao;  Trogisch, Stefan;  Wang, Zhengwen;  Welk, Erik;  Wirth, Christian;  Wubet, Tesfaye;  Xiang, Wenhua;  Yu, Mingjian;  Yu, Xiao-Dong;  Zhang, Jiayong;  Zhang, Shouren;  Zhang, Naili;  Zhou, Hong-Zhang;  Zhu, Chao-Dong;  Zhu, Li;  Bruelheide, Helge;  Ma, Keping;  Niklaus, Pascal A.;  Schmid, Bernhard
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Salt Dynamics in Coastal Marshes: Formation of Hypersaline Zones 期刊论文
WATER RESOURCES RESEARCH, 2018, 54 (5) : 3259-3276
作者:  Shen, Chengji;  Zhang, Chenming;  Xin, Pei;  Kong, Jun;  Li, Ling
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09