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A systematic global stocktake of evidence on human adaptation to climate change 科技报告
来源:Climate Analytics. 出版年: 2021
作者:  Lea Berrang-Ford;  A. R. Siders;  Alexandra Lesnikowski;  Alexandra Paige Fischer;  Max W. Callaghan;  Neal R. Haddaway;  Katharine J. Mach;  Malcolm Araos;  Mohammad Aminur Rahman Shah;  Mia Wannewitz;  Deepal Doshi;  Timo Leiter;  Custodio Matavel;  Justice Issah Musah-Surugu;  Gabrielle Wong-Parodi;  Philip Antwi-Agyei;  Idowu Ajibade;  Neha Chauhan;  William Kakenmaster;  Caitlin Grady;  Vasiliki I. Chalastani;  Kripa Jagannathan;  Eranga K. Galappaththi;  Asha Sitati;  Giulia Scarpa;  Edmond Totin;  Katy Davis;  Nikita Charles Hamilton;  Christine J. Kirchhoff;  Praveen Kumar;  Brian Pentz;  Nicholas P. Simpson;  Emily Theokritoff;  Delphine Deryng;  Diana Reckien;  Carol Zavaleta-Cortijo;  Nicola Ulibarri;  Alcade C. Segnon;  Vhalinavho Khavhagali;  Yuanyuan Shang;  Luckson Zvobgo;  Zinta Zommers;  Jiren Xu;  Portia Adade Williams;  Ivan Villaverde Canosa;  Nicole van Maanen;  Bianca van Bavel;  Maarten van Aalst;  Lynée L. Turek-Hankins;  Hasti Trivedi;  Christopher H. Trisos;  Adelle Thomas;  Shinny Thakur;  Sienna Templeman;  Lindsay C. Stringer;  Garry Sotnik;  Kathryn Dana Sjostrom;  Chandni Singh;  Mariella Z. Siña;  Roopam Shukla;  Jordi Sardans;  Eunice A. Salubi;  Lolita Shaila Safaee Chalkasra;  Raquel Ruiz-Díaz;  Carys Richards;  Pratik Pokharel;  Jan Petzold;  Josep Penuelas;  Julia Pelaez Avila;  Julia B. Pazmino Murillo;  Souha Ouni;  Jennifer Niemann;  Miriam Nielsen;  Mark New;  Patricia Nayna Schwerdtle;  Gabriela Nagle Alverio;  Cristina A. Mullin;  Joshua Mullenite;  Anuszka Mosurska;  Mike D. Morecroft;  Jan C. Minx;  Gina Maskell;  Abraham Marshall Nunbogu;  Alexandre K. Magnan;  Shuaib Lwasa;  Megan Lukas-Sithole;  Tabea Lissner;  Oliver Lilford;  Steven F. Koller;  Matthew Jurjonas;  Elphin Tom Joe;  Lam T. M. Huynh;  Avery Hill;  Rebecca R. Hernandez;  Greeshma Hegde;  Tom Hawxwell;  Sherilee Harper;  Alexandra Harden;  Marjolijn Haasnoot;  Elisabeth A. Gilmore;  Leah Gichuki;  Alyssa Gatt;  Matthias Garschagen;  James D. Ford;  Andrew Forbes;  Aidan D. Farrell;  Carolyn A. F. Enquist;  Susan Elliott;  Emily Duncan;  Erin Coughlan de Perez;  Shaugn Coggins;  Tara Chen;  Donovan Campbell;  Katherine E. Browne;  Kathryn J. Bowen;  Robbert Biesbroek;  Indra D. Bhatt;  Rachel Bezner Kerr;  Stephanie L. Barr;  Emily Baker;  Stephanie E. Austin;  Ingrid Arotoma-Rojas;  Christa Anderson;  Warda Ajaz;  Tanvi Agrawal;  Thelma Zulfawu Abu
收藏  |  浏览/下载:20/0  |  提交时间:2022/01/29
Plant “helper” immune receptors are Ca2+-permeable nonselective cation channels 期刊论文
Science, 2021
作者:  Pierre Jacob;  Nak Hyun Kim;  Feihua Wu;  Farid El-Kasmi;  Yuan Chi;  William G. Walton;  Oliver J. Furzer;  Adam D. Lietzan;  Sruthi Sunil;  Korina Kempthorn;  Matthew R. Redinbo;  Zhen-Ming Pei;  Li Wan;  Jeffery L. Dangl
收藏  |  浏览/下载:15/0  |  提交时间:2021/07/27
Catalytic asymmetric and stereodivergent oligonucleotide synthesis 期刊论文
Science, 2021
作者:  Aaron L. Featherston;  Yongseok Kwon;  Matthew M. Pompeo;  Oliver D. Engl;  David K. Leahy;  Scott J. Miller
收藏  |  浏览/下载:12/0  |  提交时间:2021/02/17
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity 期刊论文
Science, 2020
作者:  Ellen Shrock;  Eric Fujimura;  Tomasz Kula;  Richard T. Timms;  I-Hsiu Lee;  Yumei Leng;  Matthew L. Robinson;  Brandon M. Sie;  Mamie Z. Li;  Yuezhou Chen;  Jennifer Logue;  Adam Zuiani;  Denise McCulloch;  Felipe J. N. Lelis;  Stephanie Henson;  Daniel R. Monaco;  Meghan Travers;  Shaghayegh Habibi;  William A. Clarke;  Patrizio Caturegli;  Oliver Laeyendecker;  Alicja Piechocka-Trocha;  Jonathan Z. Li;  Ashok Khatri;  Helen Y. Chu;  MGH COVID-19 Collection &;  amp;  Processing Team16‡;  Alexandra-Chloé Villani;  Kyle Kays;  Marcia B. Goldberg;  Nir Hacohen;  Michael R. Filbin;  Xu G. Yu;  Bruce D. Walker;  Duane R. Wesemann;  H. Benjamin Larman;  James A. Lederer;  Stephen J. Elledge
收藏  |  浏览/下载:11/0  |  提交时间:2020/11/30
Ecological insights from three decades of animal movement tracking across a changing Arctic 期刊论文
Science, 2020
作者:  Sarah C. Davidson;  Gil Bohrer;  Eliezer Gurarie;  Scott LaPoint;  Peter J. Mahoney;  Natalie T. Boelman;  Jan U. H. Eitel;  Laura R. Prugh;  Lee A. Vierling;  Jyoti Jennewein;  Emma Grier;  Ophélie Couriot;  Allicia P. Kelly;  Arjan J. H. Meddens;  Ruth Y. Oliver;  Roland Kays;  Martin Wikelski;  Tomas Aarvak;  Joshua T. Ackerman;  José A. Alves;  Erin Bayne;  Bryan Bedrosian;  Jerrold L. Belant;  Andrew M. Berdahl;  Alicia M. Berlin;  Dominique Berteaux;  Joël Bêty;  Dmitrijs Boiko;  Travis L. Booms;  Bridget L. Borg;  Stan Boutin;  W. Sean Boyd;  Kane Brides;  Stephen Brown;  Victor N. Bulyuk;  Kurt K. Burnham;  David Cabot;  Michael Casazza;  Katherine Christie;  Erica H. Craig;  Shanti E. Davis;  Tracy Davison;  Dominic Demma;  Christopher R. DeSorbo;  Andrew Dixon;  Robert Domenech;  Götz Eichhorn;  Kyle Elliott;  Joseph R. Evenson;  Klaus-Michael Exo;  Steven H. Ferguson;  Wolfgang Fiedler;  Aaron Fisk;  Jérôme Fort;  Alastair Franke;  Mark R. Fuller;  Stefan Garthe;  Gilles Gauthier;  Grant Gilchrist;  Petr Glazov;  Carrie E. Gray;  David Grémillet;  Larry Griffin;  Michael T. Hallworth;  Autumn-Lynn Harrison;  Holly L. Hennin;  J. Mark Hipfner;  James Hodson;  James A. Johnson;  Kyle Joly;  Kimberly Jones;  Todd E. Katzner;  Jeff W. Kidd;  Elly C. Knight;  Michael N. Kochert;  Andrea Kölzsch;  Helmut Kruckenberg;  Benjamin J. Lagassé;  Sandra Lai;  Jean-François Lamarre;  Richard B. Lanctot;  Nicholas C. Larter;  A. David M. Latham;  Christopher J. Latty;  James P. Lawler;  Don-Jean Léandri-Breton;  Hansoo Lee;  Stephen B. Lewis;  Oliver P. Love;  Jesper Madsen;  Mark Maftei;  Mark L. Mallory;  Buck Mangipane;  Mikhail Y. Markovets;  Peter P. Marra;  Rebecca McGuire;  Carol L. McIntyre;  Emily A. McKinnon;  Tricia A. Miller;  Sander Moonen;  Tong Mu;  Gerhard J. D. M. Müskens;  Janet Ng;  Kerry L. Nicholson;  Ingar Jostein Øien;  Cory Overton;  Patricia A. Owen;  Allison Patterson;  Aevar Petersen;  Ivan Pokrovsky;  Luke L. Powell;  Rui Prieto;  Petra Quillfeldt;  Jennie Rausch;  Kelsey Russell;  Sarah T. Saalfeld;  Hans Schekkerman;  Joel A. Schmutz;  Philipp Schwemmer;  Dale R. Seip;  Adam Shreading;  Mónica A. Silva;  Brian W. Smith;  Fletcher Smith;  Jeff P. Smith;  Katherine R. S. Snell;  Aleksandr Sokolov;  Vasiliy Sokolov;  Diana V Solovyeva;  Mathew S. Sorum;  Grigori Tertitski;  J. F. Therrien;  Kasper Thorup;  T. Lee Tibbitts;  Ingrid Tulp;  Brian D. Uher-Koch;  Rob S. A. van Bemmelen;  Steven Van Wilgenburg;  Andrew L. Von Duyke;  Jesse L. Watson;  Bryan D. Watts;  Judy A. Williams;  Matthew T. Wilson;  James R. Wright;  Michael A. Yates;  David J. Yurkowski;  Ramūnas Žydelis;  Mark Hebblewhite
收藏  |  浏览/下载:19/0  |  提交时间:2020/11/09
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California 期刊论文
Science, 2020
作者:  Xianding Deng;  Wei Gu;  Scot Federman;  Louis du Plessis;  Oliver G. Pybus;  Nuno R. Faria;  Candace Wang;  Guixia Yu;  Brian Bushnell;  Chao-Yang Pan;  Hugo Guevara;  Alicia Sotomayor-Gonzalez;  Kelsey Zorn;  Allan Gopez;  Venice Servellita;  Elaine Hsu;  Steve Miller;  Trevor Bedford;  Alexander L. Greninger;  Pavitra Roychoudhury;  Lea M. Starita;  Michael Famulare;  Helen Y. Chu;  Jay Shendure;  Keith R. Jerome;  Catie Anderson;  Karthik Gangavarapu;  Mark Zeller;  Emily Spencer;  Kristian G. Andersen;  Duncan MacCannell;  Clinton R. Paden;  Yan Li;  Jing Zhang;  Suxiang Tong;  Gregory Armstrong;  Scott Morrow;  Matthew Willis;  Bela T. Matyas;  Sundari Mase;  Olivia Kasirye;  Maggie Park;  Godfred Masinde;  Curtis Chan;  Alexander T. Yu;  Shua J. Chai;  Elsa Villarino;  Brandon Bonin;  Debra A. Wadford;  Charles Y. Chiu
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/09
Mating patterns influence vulnerability to the extinction vortex 期刊论文
Global Change Biology, 2020
作者:  Joanne L. Godwin;  Alyson J. Lumley;  Ł;  ukasz Michalczyk;  Oliver Y. Martin;  Matthew J. G. Gage
收藏  |  浏览/下载:4/0  |  提交时间:2020/06/22
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Investigating the regional contributions to air pollution in Beijing: a dispersion modelling study using CO as a tracer 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2825-2838
作者:  Panagi, Marios;  Fleming, Zoe L.;  Monks, Paul S.;  Ashfold, Matthew J.;  Wild, Oliver;  Hollaway, Michael;  Zhang, Qiang;  Squires, Freya A.;  Vande Hey, Joshua
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Intraplate volcanism originating from upwelling hydrous mantle transition zone 期刊论文
NATURE, 2020
作者:  Calabrese, Claudia;  Davidson, Natalie R.;  Demircioglu, Deniz;  Fonseca, Nuno A.;  He, Yao;  Kahles, Andre;  Kjong-Van Lehmann;  Liu, Fenglin;  Shiraishi, Yuichi;  Soulette, Cameron M.;  Urban, Lara;  Greger, Liliana;  Li, Siliang;  Liu, Dongbing;  Perry, Marc D.;  Xiang, Qian;  Zhang, Fan;  Zhang, Junjun;  Bailey, Peter;  Erkek, Serap;  Hoadley, Katherine A.;  Hou, Yong;  Huska, Matthew R.;  Kilpinen, Helena;  Korbel, Jan O.;  Marin, Maximillian G.;  Markowski, Julia;  Nandi, Tannistha;  Pan-Hammarstrom, Qiang;  Pedamallu, Chandra Sekhar;  Siebert, Reiner;  Stark, Stefan G.;  Su, Hong;  Tan, Patrick;  Waszak, Sebastian M.;  Yung, Christina;  Zhu, Shida;  Awadalla, Philip;  Creighton, Chad J.;  Meyerson, Matthew;  Ouellette, B. F. Francis;  Wu, Kui;  Yang, Huanming;  Brazma, Alvis;  Brooks, Angela N.;  Goke, Jonathan;  Raetsch, Gunnar;  Schwarz, Roland F.;  Stegle, Oliver;  Zhang, Zemin
收藏  |  浏览/下载:71/0  |  提交时间:2020/05/13

Most magmatism occurring on Earth is conventionally attributed to passive mantle upwelling at mid-ocean ridges, to slab devolatilization at subduction zones, or to mantle plumes. However, the widespread Cenozoic intraplate volcanism in northeast China(1-3) and the young petit-spot volcanoes(4-7) offshore of the Japan Trench cannot readily be associated with any of these mechanisms. In addition, the mantle beneath these types of volcanism is characterized by zones of anomalously low seismic velocity above and below the transition zone(8-12) (a mantle level located at depths between 410 and 660 kilometres). A comprehensive interpretation of these phenomena is lacking. Here we show that most (or possibly all) of the intraplate and petit-spot volcanism and low-velocity zones around the Japanese subduction zone can be explained by the Cenozoic interaction of the subducting Pacific slab with a hydrous mantle transition zone. Numerical modelling indicates that 0.2 to 0.3 weight per cent of water dissolved in mantle minerals that are driven out from the transition zone in response to subduction and retreat of a tectonic plate is sufficient to reproduce the observations. This suggests that a critical amount of water may have accumulated in the transition zone around this subduction zone, as well as in others of the Tethyan tectonic belt(13) that are characterized by intraplate or petit-spot volcanism and low-velocity zones in the underlying mantle.


The widespread intraplate volcanism in northeast China and the unusual '  petit-spot'  volcanoes offshore Japan could have resulted from the interaction of the subducting Pacific slab with a hydrous mantle transition zone.