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Climate-induced outbreaks in high-elevation pines are driven primarily by immigration of bark beetles from historical hosts 期刊论文
Global Change Biology, 2021
作者:  Michael Howe;  Allan Carroll;  Claudio Gratton;  Kenneth F. Raffa
收藏  |  浏览/下载:8/0  |  提交时间:2021/09/14
Photocatalytic C–H activation and the subtle role of chlorine radical complexation in reactivity 期刊论文
Science, 2021
作者:  Qiaomu Yang;  Yu-Heng Wang;  Yusen Qiao;  Michael Gau;  Patrick J. Carroll;  Patrick J. Walsh;  Eric J. Schelter
收藏  |  浏览/下载:17/0  |  提交时间:2021/06/07
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Probing the core of the strong nuclear interaction 期刊论文
NATURE, 2020, 578 (7796) : 540-+
作者:  Bialas, Allison R.;  Presumey, Jessy;  Das, Abhishek;  van der Poel, Cees E.;  Lapchak, Peter H.;  Mesin, Luka;  Victora, Gabriel;  Tsokos, George C.;  Mawrin, Christian;  Herbst, Ronald;  Carroll, Michael C.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

High-energy electron scattering that can isolate pairs of nucleons in high-momentum configurations reveals a transition to spin-independent scalar forces at small separation distances, supporting the use of point-like nucleon models to describe dense nuclear systems.


The strong nuclear interaction between nucleons (protons and neutrons) is the effective force that holds the atomic nucleus together. This force stems from fundamental interactions between quarks and gluons (the constituents of nucleons) that are described by the equations of quantum chromodynamics. However, as these equations cannot be solved directly, nuclear interactions are described using simplified models, which are well constrained at typical inter-nucleon distances(1-5) but not at shorter distances. This limits our ability to describe high-density nuclear matter such as that in the cores of neutron stars(6). Here we use high-energy electron scattering measurements that isolate nucleon pairs in short-distance, high-momentum configurations(7-9), accessing a kinematical regime that has not been previously explored by experiments, corresponding to relative momenta between the pair above 400 megaelectronvolts per c (c, speed of light in vacuum). As the relative momentum between two nucleons increases and their separation thereby decreases, we observe a transition from a spin-dependent tensor force to a predominantly spin-independent scalar force. These results demonstrate the usefulness of using such measurements to study the nuclear interaction at short distances and also support the use of point-like nucleon models with two- and three-body effective interactions to describe nuclear systems up to densities several times higher than the central density of the nucleus.


  
Patterns of somatic structural variation in human cancer genomes 期刊论文
NATURE, 2020, 578 (7793) : 112-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes(1-7). Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumour types(8). Sixteen signatures of structural variation emerged. Deletions have a multimodal size distribution, assort unevenly across tumour types and patients, are enriched in late-replicating regions and correlate with inversions. Tandem duplications also have a multimodal size distribution, but are enriched in early-replicating regions-as are unbalanced translocations. Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements. One prominent structure consists of 2-7 templates copied from distinct regions of the genome strung together within one locus. Such cycles of templated insertions correlate with tandem duplications, and-in liver cancerfrequently activate the telomerase gene TERT. A wide variety of rearrangement processes are active in cancer, which generate complex configurations of the genome upon which selection can act.


  
Marine top predators as climate and ecosystem sentinels 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2019
作者:  Hazen, Elliott L.;  Abrahms, Briana;  Brodie, Stephanie;  Carroll, Gemma;  Jacox, Michael G.;  Savoca, Matthew S.;  Scales, Kylie L.;  Sydeman, William J.;  Bograd, Steven J.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Coherent coupling between a quantum dot and a donor in silicon 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Harvey-Collard, Patrick;  Jacobson, N. Tobias;  Rudolph, Martin;  Dominguez, Jason;  Ten Eyck, Gregory A.;  Wendt, Joel R.;  Pluym, Tammy;  Gamble, John King;  Lilly, Michael P.;  Pioro-Ladriere, Michel;  Carroll, Malcolm S.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Animal cultures matter for conservation 期刊论文
SCIENCE, 2019, 363 (6431) : 1032-+
作者:  Brakes, Philippa;  Dall, Sasha R. X.;  Aplin, Lucy M.;  Bearhop, Stuart;  Carroll, Emma L.;  Ciucci, Paolo;  Fishlock, Vicki;  Ford, John K. B.;  Garland, Ellen C.;  Keith, Sally A.;  McGregor, Peter K.;  Mesnick, Sarah L.;  Noad, Michael J.;  di Sciara, Giuseppe Notarbartolo;  Robbins, Martha M.;  Simmonds, Mark P.;  Spina, Fernando;  Thornton, Alex;  Wade, Paul R.;  Whiting, Martin J.;  Williams, James;  Rendell, Luke;  Whitehead, Hal;  Whiten, Andrew;  Rutz, Christian
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice 期刊论文
SCIENCE, 2018, 359 (6382) : 1403-1407
作者:  Pereira, Ethel R.;  Kedrin, Dmitriy;  Seano, Giorgio;  Gautier, Olivia;  Meijer, Eelco F. J.;  Jones, Dennis;  Chin, Shan-Min;  Kitahara, Shuji;  Bouta, Echoe M.;  Chang, Jonathan;  Beech, Elizabeth;  Jeong, Han-Sin;  Carroll, Michael C.;  Taghian, Alphonse G.;  Padera, Timothy P.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Phenotype risk scores identify patients with unrecognized Mendelian disease patterns 期刊论文
SCIENCE, 2018, 359 (6381) : 1233-+
作者:  Bastarache, Lisa;  Hughey, Jacob J.;  Hebbring, Scott;  Marlo, Joy;  Zhao, Wanke;  Ho, Wanting T.;  Van Driest, Sara L.;  McGregor, Tracy L.;  Mosley, Jonathan D.;  Wells, Quinn S.;  Temple, Michael;  Ramirez, Andrea H.;  Carroll, Robert;  Osterman, Travis;  Edwards, Todd;  Ruderfer, Douglas;  Edwards, Digna R. Velez;  Hamid, Rizwan;  Cogan, Joy;  Glazer, Andrew;  Wei, Wei-Qi;  Feng, QiPing;  Brilliant, Murray;  Zhao, Zhizhuang J.;  Cox, Nancy J.;  Roden, Dan M.;  Denny, Joshua C.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27