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Approaching the motional ground state of a 10-kg object 期刊论文
Science, 2021
作者:  Chris Whittle;  Evan D. Hall;  Sheila Dwyer;  Nergis Mavalvala;  Vivishek Sudhir;  R. Abbott;  A. Ananyeva;  C. Austin;  L. Barsotti;  J. Betzwieser;  C. D. Blair;  A. F. Brooks;  D. D. Brown;  A. Buikema;  C. Cahillane;  J. C. Driggers;  A. Effler;  A. Fernandez-Galiana;  P. Fritschel;  V. V. Frolov;  T. Hardwick;  M. Kasprzack;  K. Kawabe;  N. Kijbunchoo;  J. S. Kissel;  G. L. Mansell;  F. Matichard;  L. McCuller;  T. McRae;  A. Mullavey;  A. Pele;  R. M. S. Schofield;  D. Sigg;  M. Tse;  G. Vajente;  D. C. Vander-Hyde;  Hang Yu;  Haocun Yu;  C. Adams;  R. X. Adhikari;  S. Appert;  K. Arai;  J. S. Areeda;  Y. Asali;  S. M. Aston;  A. M. Baer;  M. Ball;  S. W. Ballmer;  S. Banagiri;  D. Barker;  J. Bartlett;  B. K. Berger;  D. Bhattacharjee;  G. Billingsley;  S. Biscans;  R. M. Blair;  N. Bode;  P. Booker;  R. Bork;  A. Bramley;  K. C. Cannon;  X. Chen;  A. A. Ciobanu;  F. Clara;  C. M. Compton;  S. J. Cooper;  K. R. Corley;  S. T. Countryman;  P. B. Covas;  D. C. Coyne;  L. E. H. Datrier;  D. Davis;  C. Di Fronzo;  K. L. Dooley;  P. Dupej;  T. Etzel;  M. Evans;  T. M. Evans;  J. Feicht;  P. Fulda;  M. Fyffe;  J. A. Giaime;  K. D. Giardina;  P. Godwin;  E. Goetz;  S. Gras;  C. Gray;  R. Gray;  A. C. Green;  E. K. Gustafson;  R. Gustafson;  J. Hanks;  J. Hanson;  R. K. Hasskew;  M. C. Heintze;  A. F. Helmling-Cornell;  N. A. Holland;  J. D. Jones;  S. Kandhasamy;  S. Karki;  P. J. King;  Rahul Kumar;  M. Landry;  B. B. Lane;  B. Lantz;  M. Laxen;  Y. K. Lecoeuche;  J. Leviton;  J. Liu;  M. Lormand;  A. P. Lundgren;  R. Macas;  M. MacInnis;  D. M. Macleod;  S. Márka;  Z. Márka;  D. V. Martynov;  K. Mason;  T. J. Massinger;  R. McCarthy;  D. E. McClelland;  S. McCormick;  J. McIver;  G. Mendell;  K. Merfeld;  E. L. Merilh;  F. Meylahn;  T. Mistry;  R. Mittleman;  G. Moreno;  C. M. Mow-Lowry;  S. Mozzon;  T. J. N. Nelson;  P. Nguyen;  L. K. Nuttall;  J. Oberling;  Richard J. Oram;  C. Osthelder;  D. J. Ottaway;  H. Overmier;  J. R. Palamos;  W. Parker;  E. Payne;  R. Penhorwood;  C. J. Perez;  M. Pirello;  H. Radkins;  K. E. Ramirez;  J. W. Richardson;  K. Riles;  N. A. Robertson;  J. G. Rollins;  C. L. Romel;  J. H. Romie;  M. P. Ross;  K. Ryan;  T. Sadecki;  E. J. Sanchez;  L. E. Sanchez;  T. R. Saravanan;  R. L. Savage;  D. Schaetz;  R. Schnabel;  E. Schwartz;  D. Sellers;  T. Shaffer;  B. J. J. Slagmolen;  J. R. Smith;  S. Soni;  B. Sorazu;  A. P. Spencer;  K. A. Strain;  L. Sun;  M. J. Szczepańczyk;  M. Thomas;  P. Thomas;  K. A. Thorne;  K. Toland;  C. I. Torrie;  G. Traylor;  A. L. Urban;  G. Valdes;  P. J. Veitch;  K. Venkateswara;  G. Venugopalan;  A. D. Viets;  T. Vo;  C. Vorvick;  M. Wade;  R. L. Ward;  J. Warner;  B. Weaver;  R. Weiss;  B. Willke;  C. C. Wipf;  L. Xiao;  H. Yamamoto;  L. Zhang;  M. E. Zucker;  J. Zweizig
收藏  |  浏览/下载：16/0  |  提交时间：2021/06/24
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease 期刊论文
Science, 2021
作者:  Sebastian Günther;  Patrick Y. A. Reinke;  Yaiza Fernández-García;  Julia Lieske;  Thomas J. Lane;  Helen M. Ginn;  Faisal H. M. Koua;  Christiane Ehrt;  Wiebke Ewert;  Dominik Oberthuer;  Oleksandr Yefanov;  Susanne Meier;  Kristina Lorenzen;  Boris Krichel;  Janine-Denise Kopicki;  Luca Gelisio;  Wolfgang Brehm;  Ilona Dunkel;  Brandon Seychell;  Henry Gieseler;  Brenna Norton-Baker;  Beatriz Escudero-Pérez;  Martin Domaracky;  Sofiane Saouane;  Alexandra Tolstikova;  Thomas A. White;  Anna Hänle;  Michael Groessler;  Holger Fleckenstein;  Fabian Trost;  Marina Galchenkova;  Yaroslav Gevorkov;  Chufeng Li;  Salah Awel;  Ariana Peck;  Miriam Barthelmess;  Frank Schlünzen;  P. Lourdu Xavier;  Nadine Werner;  Hina Andaleeb;  Najeeb Ullah;  Sven Falke;  Vasundara Srinivasan;  Bruno Alves França;  Martin Schwinzer;  Hévila Brognaro;  Cromarte Rogers;  Diogo Melo;  Joanna J. Zaitseva-Doyle;  Juraj Knoska;  Gisel E. Peña-Murillo;  Aida Rahmani Mashhour;  Vincent Hennicke;  Pontus Fischer;  Johanna Hakanpää;  Jan Meyer;  Philip Gribbon;  Bernhard Ellinger;  Maria Kuzikov;  Markus Wolf;  Andrea R. Beccari;  Gleb Bourenkov;  David von Stetten;  Guillaume Pompidor;  Isabel Bento;  Saravanan Panneerselvam;  Ivars Karpics;  Thomas R. Schneider;  Maria Marta Garcia-Alai;  Stephan Niebling;  Christian Günther;  Christina Schmidt;  Robin Schubert;  Huijong Han;  Juliane Boger;  Diana C. F. Monteiro;  Linlin Zhang;  Xinyuanyuan Sun;  Jonathan Pletzer-Zelgert;  Jan Wollenhaupt;  Christian G. Feiler;  Manfred S. Weiss;  Eike-Christian Schulz;  Pedram Mehrabi;  Katarina Karničar;  Aleksandra Usenik;  Jure Loboda;  Henning Tidow;  Ashwin Chari;  Rolf Hilgenfeld;  Charlotte Uetrecht;  Russell Cox;  Andrea Zaliani;  Tobias Beck;  Matthias Rarey;  Stephan Günther;  Dusan Turk;  Winfried Hinrichs;  Henry N. Chapman;  Arwen R. Pearson;  Christian Betzel;  Alke Meents
收藏  |  浏览/下载：14/0  |  提交时间：2021/05/14
Mechanism and dynamics of fatty acid photodecarboxylase 期刊论文
Science, 2021
作者:  D. Sorigué;  K. Hadjidemetriou;  S. Blangy;  G. Gotthard;  A. Bonvalet;  N. Coquelle;  P. Samire;  A. Aleksandrov;  L. Antonucci;  A. Benachir;  S. Boutet;  M. Byrdin;  M. Cammarata;  S. Carbajo;  S. Cuiné;  R. B. Doak;  L. Foucar;  A. Gorel;  M. Grünbein;  E. Hartmann;  R. Hienerwadel;  M. Hilpert;  M. Kloos;  T. J. Lane;  B. Légeret;  P. Legrand;  Y. Li-Beisson;  S. L. Y. Moulin;  D. Nurizzo;  G. Peltier;  G. Schirò;  R. L. Shoeman;  M. Sliwa;  X. Solinas;  B. Zhuang;  T. R. M. Barends;  J.-P. Colletier;  M. Joffre;  A. Royant;  C. Berthomieu;  M. Weik;  T. Domratcheva;  K. Brettel;  M. H. Vos;  I. Schlichting;  P. Arnoux;  P. Müller;  F. Beisson
收藏  |  浏览/下载：9/0  |  提交时间：2021/04/12
Climate drives the geography of marine consumption by changing predator communities 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Matthew A. Whalen;  Ross D. B. Whippo;  John J. Stachowicz;  Paul H. York;  Erin Aiello;  Teresa Alcoverro;  Andrew H. Altieri;  Lisandro Benedetti-Cecchi;  Camilla Bertolini;  Midoli Bresch;  Fabio Bulleri;  Paul E. Carnell;  Stéphanie Cimon;  Rod M. Connolly;  Mathieu Cusson;  Meredith S. Diskin;  Elrika D’Souza;  Augusto A. V. Flores;  F. Joel Fodrie;  Aaron W. E. Galloway;  Leo C. Gaskins;  Olivia J. Graham;  Torrance C. Hanley;  Christopher J. Henderson;  Clara M. Hereu;  Margot Hessing-Lewis;  Kevin A. Hovel;  Brent B. Hughes;  A. Randall Hughes;  Kristin M. Hultgren;  Holger Jänes;  Dean S. Janiak;  Lane N. Johnston;  Pablo Jorgensen;  Brendan P. Kelaher;  Claudia Kruschel;  Brendan S. Lanham;  Kun-Seop Lee;  Jonathan S. Lefcheck;  Enrique Lozano-Álvarez;  Peter I. Macreadie;  Zachary L. Monteith;  Nessa E. O’Connor;  Andrew D. Olds;  Jennifer K. O’Leary;  Christopher J. Patrick;  Oscar Pino;  Alistair G. B. Poore;  Michael A. Rasheed;  Wendel W. Raymond;  Katrin Reiss;  O. Kennedy Rhoades;  Max T. Robinson;  Paige G. Ross;  Francesca Rossi;  Thomas A. Schlacher;  Janina Seemann;  Brian R. Silliman;  Delbert L. Smee;  Martin Thiel;  Richard K. F. Unsworth;  Brigitta I. van Tussenbroek;  Adriana Vergés;  Mallarie E. Yeager;  Bree K. Yednock;  Shelby L. Ziegler;  J. Emmett Duffy
收藏  |  浏览/下载：24/0  |  提交时间：2020/11/09
Optimisation of energetic and reproductive gains explains behavioural responses to environmental variation across seasons and years 期刊论文
ECOLOGY LETTERS, 2020, 23 (5) : 841-850
作者:  Studd, E. K.;  Menzies, A. K.;  Siracusa, E. R.;  Dantzer, B.;  Lane, J. E.;  McAdam, A. G.;  Boutin, S.;  Humphries, M. M.
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/02
Accelerometer  behaviour  decision-making  energetic gain  hoarding  metabolic ecology  optimal behaviour  Tamiasciurus hudsonicus  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Predation drives recurrent convergence of an interspecies mutualism 期刊论文
ECOLOGY LETTERS, 2019, 22 (2) : 256-264
作者:  Feeney, William E.;  Brooker, Rohan M.;  Johnston, Lane N.;  Gilbert, James D. J.;  Besson, Marc;  Lecchini, David;  Dixson, Danielle L.;  Cowman, Peter F.;  Manica, Andrea
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
convergent evolution  cooperation  coral reefs  mutualism  predator-prey interactions