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Satellite-derived Constraints on the Effect of Drought Stress on Biogenic Isoprene Emissions in the Southeast US 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Yuxuan Wang, Nan Lin, Wei Li, Alex Guenther, Joey C. Y. Lam, Amos P. K. Tai, Mark J. Potosnak, and Roger Seco
收藏  |  浏览/下载:12/0  |  提交时间:2022/06/24
Diel Redox Cycle of Manganese in the Surface Arctic Ocean 期刊论文
Geophysical Research Letters, 2021
作者:  Y. Xiang;  P. J. Lam;  J. M. Lee
收藏  |  浏览/下载:10/0  |  提交时间:2021/11/23
A systematic global stocktake of evidence on human adaptation to climate change 科技报告
来源:Climate Analytics. 出版年: 2021
作者:  Lea Berrang-Ford;  A. R. Siders;  Alexandra Lesnikowski;  Alexandra Paige Fischer;  Max W. Callaghan;  Neal R. Haddaway;  Katharine J. Mach;  Malcolm Araos;  Mohammad Aminur Rahman Shah;  Mia Wannewitz;  Deepal Doshi;  Timo Leiter;  Custodio Matavel;  Justice Issah Musah-Surugu;  Gabrielle Wong-Parodi;  Philip Antwi-Agyei;  Idowu Ajibade;  Neha Chauhan;  William Kakenmaster;  Caitlin Grady;  Vasiliki I. Chalastani;  Kripa Jagannathan;  Eranga K. Galappaththi;  Asha Sitati;  Giulia Scarpa;  Edmond Totin;  Katy Davis;  Nikita Charles Hamilton;  Christine J. Kirchhoff;  Praveen Kumar;  Brian Pentz;  Nicholas P. Simpson;  Emily Theokritoff;  Delphine Deryng;  Diana Reckien;  Carol Zavaleta-Cortijo;  Nicola Ulibarri;  Alcade C. Segnon;  Vhalinavho Khavhagali;  Yuanyuan Shang;  Luckson Zvobgo;  Zinta Zommers;  Jiren Xu;  Portia Adade Williams;  Ivan Villaverde Canosa;  Nicole van Maanen;  Bianca van Bavel;  Maarten van Aalst;  Lynée L. Turek-Hankins;  Hasti Trivedi;  Christopher H. Trisos;  Adelle Thomas;  Shinny Thakur;  Sienna Templeman;  Lindsay C. Stringer;  Garry Sotnik;  Kathryn Dana Sjostrom;  Chandni Singh;  Mariella Z. Siña;  Roopam Shukla;  Jordi Sardans;  Eunice A. Salubi;  Lolita Shaila Safaee Chalkasra;  Raquel Ruiz-Díaz;  Carys Richards;  Pratik Pokharel;  Jan Petzold;  Josep Penuelas;  Julia Pelaez Avila;  Julia B. Pazmino Murillo;  Souha Ouni;  Jennifer Niemann;  Miriam Nielsen;  Mark New;  Patricia Nayna Schwerdtle;  Gabriela Nagle Alverio;  Cristina A. Mullin;  Joshua Mullenite;  Anuszka Mosurska;  Mike D. Morecroft;  Jan C. Minx;  Gina Maskell;  Abraham Marshall Nunbogu;  Alexandre K. Magnan;  Shuaib Lwasa;  Megan Lukas-Sithole;  Tabea Lissner;  Oliver Lilford;  Steven F. Koller;  Matthew Jurjonas;  Elphin Tom Joe;  Lam T. M. Huynh;  Avery Hill;  Rebecca R. Hernandez;  Greeshma Hegde;  Tom Hawxwell;  Sherilee Harper;  Alexandra Harden;  Marjolijn Haasnoot;  Elisabeth A. Gilmore;  Leah Gichuki;  Alyssa Gatt;  Matthias Garschagen;  James D. Ford;  Andrew Forbes;  Aidan D. Farrell;  Carolyn A. F. Enquist;  Susan Elliott;  Emily Duncan;  Erin Coughlan de Perez;  Shaugn Coggins;  Tara Chen;  Donovan Campbell;  Katherine E. Browne;  Kathryn J. Bowen;  Robbert Biesbroek;  Indra D. Bhatt;  Rachel Bezner Kerr;  Stephanie L. Barr;  Emily Baker;  Stephanie E. Austin;  Ingrid Arotoma-Rojas;  Christa Anderson;  Warda Ajaz;  Tanvi Agrawal;  Thelma Zulfawu Abu
收藏  |  浏览/下载:23/0  |  提交时间:2022/01/29
Emerging contaminants and biological effects in Arctic wildlife 期刊论文
Trends in Ecology & Evolution\, 2021
作者:  Christian Sonne:Rune Dietz:Bjørn Munro Jenssen:Su Shiung Lam:Robert J. Letcher
收藏  |  浏览/下载:12/0  |  提交时间:2021/02/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:27/0  |  提交时间:2020/12/07
Revealing enigmatic mucus structures in the deep sea using DeepPIV 期刊论文
NATURE, 2020, 583 (7814) : 78-+
作者:  Nguyen, Ngoc Uyen Nhi;  Canseco, Diana C.;  Xiao, Feng;  Nakada, Yuji;  Li, Shujuan;  Lam, Nicholas T.;  Muralidhar, Shalini A.;  Savla, Jainy J.;  Hill, Joseph A.;  Le, Victor;  Zidan, Kareem A.;  El-Feky, Hamed W.;  Wang, Zhaoning;  Ahmed, Mahmoud Salama;  Hubbi, Maimon E.;  Menendez-Montes, Ivan
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09

Advanced deep-sea imaging tools yield insights into the structure and function of mucus filtration houses built by midwater giant larvaceans.


Many animals build complex structures to aid in their survival, but very few are built exclusively from materials that animals create (1,2). In the midwaters of the ocean, mucoid structures are readily secreted by numerous animals, and serve many vital functions(3,4). However, little is known about these mucoid structures owing to the challenges of observing them in the deep sea. Among these mucoid forms, the '  houses'  of larvaceans are marvels of nature(5), and in the ocean twilight zone giant larvaceans secrete and build mucus filtering structures that can reach diameters of more than 1 m(6). Here we describe in situ laser-imaging technology(7) that reconstructs three-dimensional models of mucus forms. The models provide high-resolution views of giant larvacean houses and elucidate the role that house structure has in food capture and predator avoidance. Now that tools exist to study mucus structures found throughout the ocean, we can shed light on some of nature'  s most complex forms.


  
Leverage points for sustainability transformation: a review on interventions in food and energy systems 期刊论文
ECOLOGICAL ECONOMICS, 2020, 171
作者:  Dorninger, Christian;  Abson, David J.;  Apetrei, Cristina I.;  Derwort, Pim;  Ives, Christopher D.;  Klaniecki, Kathleen;  Lam, David P. M.;  Langsenlehne, Maria;  Riechers, Maraja;  Spittler, Nathalie;  von Wehrden, Henrik
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Energy system  Food system  Leverage points  Sustainability interventions  Sustainability transformation  
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Net emission reductions from electric cars and heat pumps in 59 world regions over time 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (6) : 437-447
作者:  Knobloch, Florian;  Hanssen, Steef V.;  Lam, Aileen;  Pollitt, Hector;  Salas, Pablo;  Chewpreecha, Unnada;  Huijbregts, Mark A. J.;  Mercure, Jean-Francois
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Multiresolution Approach to Condition Categorical Multiple-Point Realizations to Dynamic Data With Iterative Ensemble Smoothing 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (2)
作者:  Lam, D. -T.;  Renard, P.;  Straubhaar, J.;  Kerrou, J.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/02