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Decay of Kelvin-Helmholtz Vortices at the Earth's Magnetopause Under Pure Southward IMF Conditions 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Nakamura, T. K. M.;  Plaschke, F.;  Hasegawa, H.;  Liu, Y. H.;  Hwang, K. J.;  Blasl, K. A.;  Nakamura, R.
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/22
Kelvin-Helmholtz instability  magnetic reconnection  magnetopause  southward IMF  PIC simulation  turbulence  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
On the Ubiquity of Magnetic Reconnection Inside Flux Transfer Event-Like Structures at the Earth's Magnetopause 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (6)
作者:  Fargette, N.;  Lavraud, B.;  Oieroset, M.;  Phan, T. D.;  Toledo-Redondo, S.;  Kieokaew, R.;  Jacquey, C.;  Fuselier, S. A.;  Trattner, K. J.;  Petrinec, S.;  Hasegawa, H.;  Garnier, P.;  Genot, V;  Lenouvel, Q.;  Fadanelli, S.;  Penou, E.;  Sauvaud, J. A.;  Avanov, D. L. A.;  Burch, J.;  Chandler, M. O.;  Coffey, V. N.;  Dorelli, J.;  Eastwood, J. P.;  Farrugia, C. J.;  Gershman, D. J.;  Giles, B. L.;  Grigorenko, E.;  Moore, T. E.;  Paterson, W. R.;  Pollock, C.;  Saito, Y.;  Schiff, C.;  Smith, S. E.
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/02
Lactose drives Enterococcus expansion to promote graft-versus-host disease 期刊论文
SCIENCE, 2019, 366 (6469) : 1143-+
作者:  Stein-Thoeringer, C. K.;  Nichols, K. B.;  Lazrak, A.;  Docampo, M. D.;  Slingerland, A. E.;  Slingerland, J. B.;  Clurman, A. G.;  Armijo, G.;  Gomes, A. L. C.;  Shono, Y.;  Staffas, A.;  da Silva, M. Burgos;  Devlin, S. M.;  Markey, K. A.;  Bajic, D.;  Pinedo, R.;  Tsakmaklis, A.;  Littmann, E. R.;  Pastore, A.;  Taur, Y.;  Monette, S.;  Arcila, M. E.;  Pickard, A. J.;  Maloy, M.;  Wright, R. J.;  Amoretti, L. A.;  Fontana, E.;  Pham, D.;  Jamal, M. A.;  Weber, D.;  Sung, A. D.;  Hashimoto, D.;  Scheid, C.;  Xavier, J. B.;  Messina, J. A.;  Romero, K.;  Lew, M.;  Bush, A.;  Bohannon, L.;  Hayasaka, K.;  Hasegawa, Y.;  Vehreschild, M. J. G. T.;  Cross, J. R.;  Ponce, D. M.;  Perales, M. A.;  Giralt, S. A.;  Jenq, R. R.;  Teshima, T.;  Holler, E.;  Chao, N. J.;  Pamer, E. G.;  Peled, J. U.;  van den Brink, M. R. M.
收藏  |  浏览/下载：14/0  |  提交时间：2020/02/17
Electron Vorticity Indicative of the Electron Diffusion Region of Magnetic Reconnection 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (12) : 6287-6296
作者:  Hwang, K. -J.;  Choi, E.;  Dokgo, K.;  Burch, J. L.;  Sibeck, D. G.;  Giles, B. L.;  Goldstein, M. L.;  Paterson, W. R.;  Pollock, C. J.;  Shi, Q. Q.;  Fu, H.;  Hasegawa, H.;  Gershman, D. J.;  Khotyaintsev, Y.;  Torbert, R. B.;  Ergun, R. E.;  Dorelli, J. C.;  Avanov, L.;  Russell, C. T.;  Strangeway, R. J.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
magnetic reconnection  electron diffusion region  electron vorticity  reconnection  magnetotail  current sheet  
The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes 期刊论文
SCIENCE, 2019, 364 (6437) : 252-+
作者:  Sugita, S.;  Honda, R.;  Morota, T.;  Kameda, S.;  Sawada, H.;  Tatsumi, E.;  Yamada, M.;  Honda, C.;  Yokota, Y.;  Kouyama, T.;  Sakatani, N.;  Ogawa, K.;  Suzuki, H.;  Okada, T.;  Namiki, N.;  Tanaka, S.;  Iijima, Y.;  Yoshioka, K.;  Hayakawa, M.;  Cho, Y.;  Matsuoka, M.;  Hirata, N.;  Hirata, N.;  Miyamoto, H.;  Domingue, D.;  Hirabayashi, M.;  Nakamura, T.;  Hiroi, T.;  Michikami, T.;  Michel, P.;  Ballouz, R. -L.;  Barnouin, O. S.;  Ernst, C. M.;  Schroeder, S. E.;  Kikuchi, H.;  Hemmi, R.;  Komatsu, G.;  Fukuhara, T.;  Taguchi, M.;  Arai, T.;  Senshu, H.;  Demura, H.;  Ogawa, Y.;  Shimaki, Y.;  Sekiguchi, T.;  Mueller, T. G.;  Hagermann, A.;  Mizuno, T.;  Noda, H.;  Matsumoto, K.;  Yamada, R.;  Ishihara, Y.;  Ikeda, H.;  Araki, H.;  Yamamoto, K.;  Abe, S.;  Yoshida, F.;  Higuchi, A.;  Sasaki, S.;  Oshigami, S.;  Tsuruta, S.;  Asari, K.;  Tazawa, S.;  Shizugami, M.;  Kimura, J.;  Otsubo, T.;  Yabuta, H.;  Hasegawa, S.;  Ishiguro, M.;  Tachibana, S.;  Palmer, E.;  Gaskell, R.;  Le Corre, L.;  Jaumann, R.;  Otto, K.;  Schmitz, N.;  Abell, P. A.;  Barucci, M. A.;  Zolensky, M. E.;  Vilas, F.;  Thuillet, F.;  Sugimoto, C.;  Takaki, N.;  Suzuki, Y.;  Kamiyoshihara, H.;  Okada, M.;  Nagata, K.;  Fujimoto, M.;  Yoshikawa, M.;  Yamamoto, Y.;  Shirai, K.;  Noguchi, R.;  Ogawa, N.;  Terui, F.;  Kikuchi, S.;  Yamaguchi, T.;  Oki, Y.;  Takao, Y.;  Takeuchi, H.;  Ono, G.;  Mimasu, Y.;  Yoshikawa, K.;  Takahashi, T.;  Takei, Y.;  Fujii, A.;  Hirose, C.;  Nakazawa, S.;  Hosoda, S.;  Mori, O.;  Shimada, T.;  Soldini, S.;  Iwata, T.;  Abe, M.;  Yano, H.;  Tsukizaki, R.;  Ozaki, M.;  Nishiyama, K.;  Saiki, T.;  Watanabe, S.;  Tsuda, Y.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Crescent-Shaped Electron Distributions at the Nonreconnecting Magnetopause: Magnetospheric Multiscale Observations 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (6) : 3024-3032
作者:  Tang, B. -B.;  Li, W. Y.;  Graham, D. B.;  Rager, A. C.;  Wang, C.;  Khotyaintsev, Yu. V.;  Lavraud, B.;  Hasegawa, H.;  Zhang, Y. -C.;  Dai, L.;  Giles, B. L.;  Dorelli, J. C.;  Russell, C. T.;  Lindqvist, P. -A.;  Ergun, R. E.;  Burch, J. L.
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/26
agyrotropic electron distributions  electron finite gyroradius effect  upper hybrid waves  
Direct measurements of two-way wave-particle energy transfer in a collisionless space plasma 期刊论文
SCIENCE, 2018, 361 (6406) : 1000-1003
作者:  Kitamura, N.;  Kitahara, M.;  Shoji, M.;  Miyoshi, Y.;  Hasegawa, H.;  Nakamura, S.;  Katoh, Y.;  Saito, Y.;  Yokota, S.;  Gershman, D. J.;  Vinas, A. F.;  Giles, B. L.;  Moore, T. E.;  Paterson, W. R.;  Pollock, C. J.;  Russell, C. T.;  Strangeway, R. J.;  Fuselier, S. A.;  Burch, J. L.
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Reconstruction of the electron diffusion region observed by the Magnetospheric Multiscale spacecraft: First results 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (10)
作者:  Hasegawa, H.;  Sonnerup, B. U. O.;  Denton, R. E.;  Phan, T. -D.;  Nakamura, T. K. M.;  Giles, B. L.;  Gershman, D. J.;  Dorelli, J. C.;  Burch, J. L.;  Torbert, R. B.;  Russell, C. T.;  Strangeway, R. J.;  Lindqvist, P. -A.;  Khotyaintsev, Y. V.;  Ergun, R. E.;  Cassak, P. A.;  Kitamura, N.;  Saito, Y.
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09