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HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
Science, 2020
作者:  Sarah A. Cook;  William A. Comrie;  M. Cecilia Poli;  Morgan Similuk;  Andrew J. Oler;  Aiman J. Faruqi;  Douglas B. Kuhns;  Sheng Yang;  Alexander Vargas-Hernández;  Alexandre F. Carisey;  Benjamin Fournier;  D. Eric Anderson;  Susan Price;  Margery Smelkinson;  Wadih Abou Chahla;  Lisa R. Forbes;  Emily M. Mace;  Tram N. Cao;  Zeynep H. Coban-Akdemir;  Shalini N. Jhangiani;  Donna M. Muzny;  Richard A. Gibbs;  James R. Lupski;  Jordan S. Orange;  Geoffrey D. E. Cuvelier;  Moza Al Hassani;  Nawal Al Kaabi;  Zain Al Yafei;  Soma Jyonouchi;  Nikita Raje;  Jason W. Caldwell;  Yanping Huang;  Janis K. Burkhardt;  Sylvain Latour;  Baoyu Chen;  Gehad ElGhazali;  V. Koneti Rao;  Ivan K. Chinn;  Michael J. Lenardo
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/14
Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
收藏  |  浏览/下载:45/0  |  提交时间:2020/05/25
Asynchronous carbon sink saturation in African and Amazonian tropical forests 期刊论文
NATURE, 2020, 579 (7797) : 80-+
作者:  Wannes Hubau;  Simon L. Lewis;  Oliver L. Phillips;  Kofi Affum-Baffoe;  Hans Beeckman;  Aida Cuní;  -Sanchez;  Armandu K. Daniels;  Corneille E. N. Ewango;  Sophie Fauset;  Jacques M. Mukinzi;  Douglas Sheil;  Bonaventure Sonké;  Martin J. P. Sullivan;  Terry C. H. Sunderland;  Hermann Taedoumg;  Sean C. Thomas;  Lee J. T. White;  Katharine A. Abernethy;  Stephen Adu-Bredu;  Christian A. Amani;  Timothy R. Baker;  Lindsay F. Banin;  Fidè;  le Baya;  Serge K. Begne;  Amy C. Bennett;  Fabrice Benedet;  Robert Bitariho;  Yannick E. Bocko;  Pascal Boeckx;  Patrick Boundja;  Roel J. W. Brienen;  Terry Brncic;  Eric Chezeaux;  George B. Chuyong;  Connie J. Clark;  Murray Collins;  James A. Comiskey;  David A. Coomes;  Greta C. Dargie;  Thales de Haulleville;  Marie Noel Djuikouo Kamdem;  Jean-Louis Doucet;  Adriane Esquivel-Muelbert;  Ted R. Feldpausch;  Alusine Fofanah;  Ernest G. Foli;  Martin Gilpin;  Emanuel Gloor;  Christelle Gonmadje;  Sylvie Gourlet-Fleury;  Jefferson S. Hall;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Mireille B. N. Hockemba;  Annette Hladik;  Suspense A. Ifo;  Kathryn J. Jeffery;  Tommaso Jucker;  Emmanuel Kasongo Yakusu;  Elizabeth Kearsley;  David Kenfack;  Alexander Koch;  Miguel E. Leal;  Aurora Levesley;  Jeremy A. Lindsell;  Janvier Lisingo;  Gabriela Lopez-Gonzalez;  Jon C. Lovett;  Jean-Remy Makana;  Yadvinder Malhi;  Andrew R. Marshall;  Jim Martin;  Emanuel H. Martin;  Faustin M. Mbayu;  Vincent P. Medjibe;  Vianet Mihindou;  Edward T. A. Mitchard;  Sam Moore;  Pantaleo K. T. Munishi;  Natacha Nssi Bengone;  Lucas Ojo;  Fidè;  le Evouna Ondo;  Kelvin S.-H. Peh;  Georgia C. Pickavance;  Axel Dalberg Poulsen;  John R. Poulsen;  Lan Qie;  Jan Reitsma;  Francesco Rovero;  Michael D. Swaine;  Joey Talbot;  James Taplin;  David M. Taylor;  Duncan W. Thomas;  Benjamin Toirambe;  John Tshibamba Mukendi;  Darlington Tuagben;  Peter M. Umunay;  Geertje M. F. van der Heijden;  Hans Verbeeck;  Jason Vleminckx;  Simon Willcock;  Hannsjö;  rg Wö;  ll;  John T. Woods;  Lise Zemagho
收藏  |  浏览/下载:30/0  |  提交时间:2020/05/13

Structurally intact tropical forests sequestered about half of the global terrestrial carbon uptake over the 1990s and early 2000s, removing about 15 per cent of anthropogenic carbon dioxide emissions(1-3). Climate-driven vegetation models typically predict that this tropical forest '  carbon sink'  will continue for decades(4,5). Here we assess trends in the carbon sink using 244 structurally intact African tropical forests spanning 11 countries, compare them with 321 published plots from Amazonia and investigate the underlying drivers of the trends. The carbon sink in live aboveground biomass in intact African tropical forests has been stable for the three decades to 2015, at 0.66 tonnes of carbon per hectare per year (95 per cent confidence interval 0.53-0.79), in contrast to the long-term decline in Amazonian forests(6). Therefore the carbon sink responses of Earth'  s two largest expanses of tropical forest have diverged. The difference is largely driven by carbon losses from tree mortality, with no detectable multi-decadal trend in Africa and a long-term increase in Amazonia. Both continents show increasing tree growth, consistent with the expected net effect of rising atmospheric carbon dioxide and air temperature(7-9). Despite the past stability of the African carbon sink, our most intensively monitored plots suggest a post-2010 increase in carbon losses, delayed compared to Amazonia, indicating asynchronous carbon sink saturation on the two continents. A statistical model including carbon dioxide, temperature, drought and forest dynamics accounts for the observed trends and indicates a long-term future decline in the African sink, whereas the Amazonian sink continues to weaken rapidly. Overall, the uptake of carbon into Earth'  s intact tropical forests peaked in the 1990s. Given that the global terrestrial carbon sink is increasing in size, independent observations indicating greater recent carbon uptake into the Northern Hemisphere landmass(10) reinforce our conclusion that the intact tropical forest carbon sink has already peaked. This saturation and ongoing decline of the tropical forest carbon sink has consequences for policies intended to stabilize Earth'  s climate.


  
Contributions of biomass-burning, urban, and biogenic emissions to the concentrations and light-absorbing properties of particulate matter in central Amazonia during the dry season 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (12) : 7973-8001
作者:  de Sa, Suzane S.;  Rizzo, Luciana V.;  Palm, Brett B.;  Campuzano-Jost, Pedro;  Day, Douglas A.;  Yee, Lindsay D.;  Wernis, Rebecca;  Isaacman-VanWertz, Gabriel;  Brito, Joel;  Carbone, Samara;  Liu, Yingjun J.;  Sedlacek, Arthur;  Springston, Stephen;  Goldstein, Allen H.;  Barbosa, Henrique M. J.;  Alexander, M. Lizabeth;  Artaxo, Paulo;  Jimenez, Jose L.;  Martin, Scot T.
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/26
A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Douglas, Alexander D.;  Baldeviano, G. Christian;  Jin, Jing;  Miura, Kazutoyo;  Diouf, Ababacar;  Zenonos, Zenon A.;  Ventocilla, Julio A.;  Silk, Sarah E.;  Marshall, Jennifer M.;  Alanine, Daniel G. W.;  Wang, Chuan;  Edwards, Nick J.;  Leiva, Karina P.;  Gomez-Puerta, Luis A.;  Lucas, Carmen M.;  Wright, Gavin J.;  Long, Carole A.;  Royale, Joseph M.;  Draper, Simon J.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight 期刊论文
SCIENCE, 2019, 364 (6436) : 144-+
作者:  Garrett-Bakelman, Francine E.;  Darshi, Manjula;  Green, Stefan J.;  Gur, Ruben C.;  Lin, Ling;  Macias, Brandon R.;  McKenna, Miles J.;  Meydan, Cem;  Mishra, Tejaswini;  Nasrini, Jad;  Piening, Brian D.;  Rizzardi, Lindsay F.;  Sharma, Kumar;  Siamwala, Jamila H.;  Taylor, Lynn;  Vitaterna, Martha Hotz;  Afkarian, Maryam;  Afshinnekoo, Ebrahim;  Ahadi, Sara;  Ambati, Aditya;  Arya, Maneesh;  Bezdan, Daniela;  Callahan, Colin M.;  Chen, Songjie;  Choi, Augustine M. K.;  Chlipala, George E.;  Contrepois, Kevin;  Covington, Marisa;  Crucian, Brian E.;  De Vivo, Immaculata;  Dinges, David F.;  Ebert, Douglas J.;  Feinberg, Jason I.;  Gandara, Jorge A.;  George, Kerry A.;  Goutsias, John;  Grills, George S.;  Hargens, Alan R.;  Heer, Martina;  Hillary, Ryan P.;  Hoofnagle, Andrew N.;  Hook, Vivian Y. H.;  Jenkinson, Garrett;  Jiang, Peng;  Keshavarzian, Ali;  Laurie, Steven S.;  Lee-McMullen, Brittany;  Lumpkins, Sarah B.;  MacKay, Matthew;  Maienschein-Cline, Mark G.;  Melnick, Ari M.;  Moore, Tyler M.;  Nakahira, Kiichi;  Patel, Hemal H.;  Pietrzyk, Robert;  Rao, Varsha;  Saito, Rintaro;  Salins, Denis N.;  Schilling, Jan M.;  Sears, Dorothy D.;  Sheridan, Caroline K.;  Stenger, Michael B.;  Tryggvadottir, Rakel;  Urban, Alexander E.;  Vaisar, Tomas;  Van Espen, Benjamin;  Zhang, Jing;  Ziegler, Michael G.;  Zwart, Sara R.;  Charles, John B.;  Kundrot, Craig E.;  Scott, Graham B. I.;  Bailey, Susan M.;  Basner, Mathias;  Feinberg, Andrew P.;  Lee, Stuart M. C.;  Mason, Christopher E.;  Mignot, Emmanuel;  Rana, Brinda K.;  Smith, Scott M.;  Snyder, Michael P.;  Turek, Fred W.
收藏  |  浏览/下载:43/0  |  提交时间:2019/11/27
Arctic marine secondary organic aerosol contributes significantly to summertime particle size distributions in the Canadian Arctic Archipelago 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (5) : 2787-2812
作者:  Croft, Betty;  Martin, Randall, V;  Leaitch, W. Richard;  Burkart, Julia;  Chang, Rachel Y-W;  Collins, Douglas B.;  Hayes, Patrick L.;  Hodshire, Anna L.;  Huang, Lin;  Kodros, John K.;  Moravek, Alexander;  Mungall, Emma L.;  Murphy, Jennifer G.;  Sharma, Sangeeta;  Tremblay, Samantha;  Wentworth, Gregory R.;  Willis, Megan D.;  Abbate, Jonathan P. D.;  Pierce, Jeffrey R.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Urban influence on the concentration and composition of submicron particulate matter in central Amazonia 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (16) : 12185-12206
作者:  de Sa, Suzane S.;  Palm, Brett B.;  Campuzano-Jost, Pedro;  Day, Douglas A.;  Hu, Weiwei;  Isaacman-VanWertz, Gabriel;  Yee, Lindsay D.;  Brito, Joel;  Carbone, Samara;  Ribeiro, Igor O.;  Cirino, Glauber G.;  Liu, Yingjun;  Thalman, Ryan;  Sedlacek, Arthur;  Funk, Aaron;  Schumacher, Courtney;  Shilling, John E.;  Schneider, Johannes;  Artaxo, Paulo;  Goldstein, Allen H.;  Souza, Rodrigo A. F.;  Wang, Jian;  McKinney, Karena A.;  Barbosa, Henrique;  Alexander, M. Lizabeth;  Jimenez, Jose L.;  Martin, Scot T.
收藏  |  浏览/下载:18/0  |  提交时间:2019/04/09
Observations of sesquiterpenes and their oxidation products in central Amazonia during the wet and dry seasons 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (14) : 10433-10457
作者:  Yee, Lindsay D.;  Isaacman-VanWertz, Gabriel;  Wernis, Rebecca A.;  Meng, Meng;  Rivera, Ventura;  Kreisberg, Nathan M.;  Hering, Susanne V.;  Bering, Mads S.;  Glasius, Marianne;  Upshur, Mary Alice;  Be, Ariana Gray;  Thomson, Regan J.;  Geiger, Franz M.;  Offenberg, John H.;  Lewandowski, Michael;  Kourtchev, Ivan;  Kalberer, Markus;  de Sa, Suzane;  Martin, Scot T.;  Alexander, M. Lizabeth;  Palm, Brett B.;  Hu, Weiwei;  Campuzano-Jost, Pedro;  Day, Douglas A.;  Jimenez, Jose L.;  Liu, Yingjun;  McKinney, Karena A.;  Artaxo, Paulo;  Viegas, Juarez;  Manzi, Antonio;  Oliveira, Maria B.;  de Souza, Rodrigo;  Machado, Luiz A. T.;  Longo, Karla;  Goldstein, Allen H.
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
Secondary organic aerosol formation from ambient air in an oxidation flow reactor in central Amazonia 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (1) : 467-493
作者:  Palm, Brett B.;  de Sa, Suzane S.;  Day, Douglas A.;  Campuzano-Jost, Pedro;  Hu, Weiwei;  Seco, Roger;  Sjostedt, Steven J.;  Park, Jeong-Hoo;  Guenther, Alex B.;  Kim, Saewung;  Brito, Joel;  Wurm, Florian;  Artaxo, Paulo;  Thalman, Ryan;  Wang, Jian;  Yee, Lindsay D.;  Wernis, Rebecca;  Isaacman-VanWertz, Gabriel;  Goldstein, Allen H.;  Liu, Yingjun;  Springston, Stephen R.;  Souza, Rodrigo;  Newburn, Matt K.;  Alexander, M. Lizabeth;  Martin, Scot T.;  Jimenez, Jose L.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09