Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-02477-1 |
A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates | |
Douglas, Alexander D.1; Baldeviano, G. Christian2; Jin, Jing1; Miura, Kazutoyo3; Diouf, Ababacar3; Zenonos, Zenon A.4; Ventocilla, Julio A.2; Silk, Sarah E.1; Marshall, Jennifer M.1; Alanine, Daniel G. W.1; Wang, Chuan1; Edwards, Nick J.1; Leiva, Karina P.2; Gomez-Puerta, Luis A.2; Lucas, Carmen M.2; Wright, Gavin J.4; Long, Carole A.3; Royale, Joseph M.2; Draper, Simon J.1 | |
2019-04-26 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Peru; USA |
英文摘要 | Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic correlate of protection. We previously demonstrated a strong association between protection and merozoite-neutralizing antibody responses following vaccination of non-human primates against Plasmodium falciparum reticulocyte binding protein homolog 5 (PfRH5). Here, we test the mechanism of protection. Using mutant human IgG1 Fc regions engineered not to engage complement or FcR-dependent effector mechanisms, we produce merozoite-neutralizing and non-neutralizing anti-PfRH5 chimeric monoclonal antibodies (mAbs) and perform a passive transfer-P. falciparum challenge study in Aotus nancymaae monkeys. At the highest dose tested, 6/6 animals given the neutralizing PfRH5-binding mAb c2AC7 survive the challenge without treatment, compared to 0/6 animals given non-neutralizing PfRH5-binding mAb c4BA7 and 0/6 animals given an isotype control mAb. Our results address the controversy regarding whether merozoite-neutralizing antibody can cause protection against P. falciparum blood-stage infections, and highlight the quantitative challenge of achieving such protection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000465838600005 |
WOS关键词 | MEROZOITE SURFACE PROTEIN-1 ; IN-VITRO ; ACQUIRED-IMMUNITY ; ANTIBODY TITER ; INVASION ; INFECTION ; VACCINES ; GROWTH ; COOPERATION ; COMPLEMENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203610 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Oxford, Jenner Inst, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England; 2.US Naval Med Res Unit 6 NAMRU 6, Av Venezuela Cuadra 36, Bellavista, Callao, Peru; 3.NIAID, Lab Malaria & Vector Res, NIH, 12735 Twinbrook Pkwy, Rockville, MD 20852 USA; 4.Wellcome Trust Sanger Inst, Cell Surface Signalling Lab, Cambridge CB10 1SA, England |
推荐引用方式 GB/T 7714 | Douglas, Alexander D.,Baldeviano, G. Christian,Jin, Jing,et al. A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Douglas, Alexander D..,Baldeviano, G. Christian.,Jin, Jing.,Miura, Kazutoyo.,Diouf, Ababacar.,...&Draper, Simon J..(2019).A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates.NATURE COMMUNICATIONS,10. |
MLA | Douglas, Alexander D.,et al."A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论